0001019687-15-002648 Sample Contracts

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • July 8th, 2015 • Xenetic Biosciences, Inc. • Pharmaceutical preparations

This Agreement is made pursuant to the Securities Purchase Agreement, dated as of the date hereof, between the Company and the Purchaser (the “Purchase Agreement”).

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TEN PERCENT (10%) SENIOR SECURED COLLATERALIZED CONVERTIBLE PROMISSORY NOTE DUE July 1, 2016
Xenetic Biosciences, Inc. • July 8th, 2015 • Pharmaceutical preparations • New York

THIS TEN PERCENT (10%) SENIOR SECURED COLLATERALIZED CONVERTIBLE PROMISSORY NOTE is a duly authorized and validly issued Ten Percent (10%) Senior Secured Collateralized Convertible Promissory Note of Xenetic Biosciences, Inc., a Nevada corporation (the “Company” or the “Borrower”), having its principal place of business at 99 Hayden Ave, Suite 230, Lexington, Massachusetts 02421, designated as its Ten Percent (10%) Senior Secured Collateralized Convertible Promissory Note due July 1, 2016 (the “Note”).

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • July 8th, 2015 • Xenetic Biosciences, Inc. • Pharmaceutical preparations • New York

This Securities Purchase Agreement (this "Agreement") is dated as of May ___, 2015 between Xenetic Biosciences, Inc., a Nevada corporation (the "Company"), and the purchaser identified on the signature pages hereto (the "Purchaser").

SECURITY AGREEMENT
Security Agreement • July 8th, 2015 • Xenetic Biosciences, Inc. • Pharmaceutical preparations • New York

This SECURITY AGREEMENT, dated as of July 1, 2015 (this “Agreement”), is among Xenetic Biosciences, Inc., a Nevada corporation (the “Company”), all of the subsidiaries of the Company (such subsidiaries, the “Guarantors” and together with the Company, the “Debtors”) and the holder of the Company’s Ten Percent (10%) Senior Secured Collateralized Convertible Promissory Note due twelve (12) months following its issuance, in the original principal amount of $3,000,000 (the “Note”) signatory hereto, its endorsees, transferees and assigns (collectively, the “Secured Parties”).

ASSIGNMENT AND ASSUMPTION AGREEMENT
Assignment and Assumption Agreement • July 8th, 2015 • Xenetic Biosciences, Inc. • Pharmaceutical preparations • New York

This Assignment and Assumption Agreement (“Assignment”) is effective as of July 1, 2015 (“Effective Date”) by and among OJSC Pharmsynthez, a Russian open joint stock company (“Pharm” or (“ASSIGNOR”) and OPKO Pharmaceuticals, LLC (“OPKO or “ASSIGNEE,” and collectively with ASSIGNOR, the “Parties”).

SUBSIDIARY GUARANTEE
Subsidiary Guarantee • July 8th, 2015 • Xenetic Biosciences, Inc. • Pharmaceutical preparations • New York

SUBSIDIARY GUARANTEE, dated as of July 1, 2015 (this “Guarantee”), made by each of the signatories hereto (together with any other entity that may become a party hereto as provided herein, the “Guarantors”), in favor of the Purchaser (together with its permitted assigns, the “Purchaser”) signatory to that certain Securities Purchase Agreement, dated as of the date hereof, between Xenetic Biosciences, Inc., a Nevada corporation (the “Company”) and the Purchaser (the “Purchase Agreement”).

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