EXHIBIT 4.12 (ASHURST MORRIS CRISP LOGO) MANUFACTURING AGREEMENT Protherics UK Limited and Chesapeake Biological Laboratories Inc. 19 March 2003Agreement • September 30th, 2003 • Protherics PLC • Pharmaceutical preparations
AMENDMENT NO. 3 TO DISTRIBUTION AGREEMENTDistribution Agreement • September 30th, 2003 • Protherics PLC • Pharmaceutical preparations • Tennessee
EXHIBIT 4.11 [ASHURST MORRIS CRISP LOGO] Supply Agreement Selborne Biological Services (Australia) Pty Limited and Protherics Australasia Pty Limited 21st October 2002Agreement • September 30th, 2003 • Protherics PLC • Pharmaceutical preparations • South Australia
ANDConsultancy Services Agreement • September 30th, 2003 • Protherics PLC • Pharmaceutical preparations
EXHIBIT 4.30 AMENDMENT TO AGREEMENT BETWEEN ENACT PHARMA PLC AND CHIMAERON LTD DATED 1ST APRIL 2000. 22nd February 2001 Following a change, the registered address of the "Company" shall now read 8 Centre One, Old Sarum Park, Lysander Way, Salisbury,...Agreement • September 30th, 2003 • Protherics PLC • Pharmaceutical preparations
Following a change, the registered address of the "Company" shall now read 8 Centre One, Old Sarum Park, Lysander Way, Salisbury, SP4 6BU.
AMENDMENT TO AGREEMENT BETWEEN ENACT PHARMA PLC AND CHIMAERON LTD DATED 1ST APRIL 2000. 1st December 2001 The paragraph referring to Consultant's Fees shall be amended to read "The fee is at present L90,000 per annum exclusive of VAT, or such other...Agreement • September 30th, 2003 • Protherics PLC • Pharmaceutical preparations
The paragraph referring to Consultant's Fees shall be amended to read "The fee is at present L90,000 per annum exclusive of VAT, or such other rate as may be agreed from time to time payable monthly in arrears by bank credit transfer. This agreement shall be terminable by either party giving to the other not less than six months' prior written notice."
