0000950134-08-022343 Sample Contracts

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • December 18th, 2008 • Ardea Biosciences, Inc./De • Pharmaceutical preparations

This Registration Rights Agreement (this “Agreement”) is made and entered into as of December 17, 2008, by and among Ardea Biosciences, Inc., a Delaware corporation (the “Company”), and the several purchasers signatory hereto (each a “Purchaser” and collectively, the “Purchasers”).

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SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • December 18th, 2008 • Ardea Biosciences, Inc./De • Pharmaceutical preparations • New York

This Securities Purchase Agreement (this “Agreement”) is dated as of December 17, 2008, by and among Ardea Biosciences, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively, the “Purchasers”).

ARDEA BIOSCIENCES, INC. WARRANT TO PURCHASE COMMON STOCK
Ardea Biosciences, Inc./De • December 18th, 2008 • Pharmaceutical preparations • California

This Certifies That, for value received, [ ], or assigns (the “Holder”), is entitled to subscribe for and purchase at the Exercise Price (defined below) from Ardea Biosciences, Inc., a Delaware corporation, with its principal office at 4939 Directors Place, San Diego, CA 92121 (the “Company”) up to [ ] shares of the common stock of the Company, par value $0.001 per share (the “Common Stock”).

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