0000950133-02-001314 Sample Contracts

FOURTH MODIFICATION AGREEMENT — LEASEHOLD DEED OF TRUST AND SECURITY AGREEMENT
Fourth Modification Agreement • April 1st, 2002 • Bioreliance Corp • Services-commercial physical & biological research • Maryland

THIS FOURTH MODIFICATION AGREEMENT — LEASEHOLD DEED OF TRUST AND SECURITY AGREEMENT (this “Amendment”) is made as of the 1st day of October, 2001 by and among BIORELIANCE CORPORATION, a corporation organized and in good standing under the laws of State of Delaware, successor in interest to and formerly known of record as MICROBIOLOGICAL ASSOCIATES, INC., (the “Grantor”), ELIZABETH F. SHORE, as trustee (the “Trustee”) and BANK OF AMERICA, N.A., successor to NATIONSBANK, N.A., a national banking association successor-in-interest to MARYLAND NATIONAL BANK, a national banking association (the “Beneficiary”).

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FOURTH AMENDMENT TO AMENDED AND RESTATED REPLACEMENT LOAN AGREEMENT
Replacement Loan Agreement • April 1st, 2002 • Bioreliance Corp • Services-commercial physical & biological research • Maryland

THIS FOURTH AMENDMENT TO AMENDED AND RESTATED REPLACEMENT LOAN AGREEMENT (the “Agreement”) is made this 1st day of October, 2001 by and among BIORELIANCE CORPORATION, a corporation organized and in good standing under the laws of the State of Delaware, successor in interest to Microbiological Associates, Inc. (the “Company”), BIORELIANCE TESTING AND DEVELOPMENT, LLC, a limited liability company organized and in good standing under the laws of the State of Delaware (“BT&D LLC”), BIORELIANCE MANUFACTURING, LLC, a limited liability company organized and in good standing under the laws of the State of Delaware (“BMF LLC”) and BIORELIANCE VIRAL MANUFACTURING, INC. (formerly known as Magenta Viral Production, Inc.), successor in interest to BioReliance Testing and Development, Inc. and BioReliance Manufacturing, Inc., a corporation organized and in good standing under the laws of the State of Delaware (“Viral Manufacturing”; together with the Company, BT&D LLC, and BMF LLC, each a “Borrower”

FOURTH DEED OF TRUST NOTE MODIFICATION AGREEMENT
Fourth Deed of Trust Note Modification Agreement • April 1st, 2002 • Bioreliance Corp • Services-commercial physical & biological research • Maryland

THIS FOURTH DEED OF TRUST NOTE MODIFICATION AGREEMENT (this “Agreement”) is made this 1st day of October, 2001, by and among BIORELIANCE CORPORATION, a corporation organized and in good standing under the laws of the State of Delaware, successor in interest to Microbiological Associates, Inc. (the “Company”), BIORELIANCE TESTING AND DEVELOPMENT, LLC, a limited liability company organized and in good standing under the laws of the State of Delaware (“BT&D LLC”), BIORELIANCE MANUFACTURING, LLC, a limited liability company organized and in good standing under the laws of the State of Delaware (“BMF LLC”) and BIORELIANCE VIRAL MANUFACTURING, INC. (formerly known as Magenta Viral Production, Inc.), successor in interest to BioReliance Testing and Development, Inc. and BioReliance Manufacturing, Inc. a corporation organized and in good standing under the laws of the State of Delaware (“Viral Manufacturing;” together with the Company and BT&D LLC and BMF LLC, each a “Borrower” and collectivel

THIRD AMENDMENT TO AMENDED AND RESTATED REPLACEMENT LOAN AGREEMENT
Replacement Loan Agreement • April 1st, 2002 • Bioreliance Corp • Services-commercial physical & biological research • Maryland

THIS THIRD AMENDMENT TO AMENDED AND RESTATED REPLACEMENT LOAN AGREEMENT (the “Agreement”) is made this 11th day of June, 2001, but effective as of the 31st day of May 2001, by and among BIORELIANCE CORPORATION, a corporation organized and in good standing under the laws of the State of Delaware, successor in interest to Microbiological Associates, Inc. (the “Company”), BIORELIANCE TESTING AND DEVELOPMENT, INC., formerly known as MA BioServices, Inc., a corporation organized and in good standing under the laws of the State of Delaware (“MA BioServices”), BIORELIANCE MANUFACTURING, INC., formerly known as Magenta Corporation, a corporation organized and in good standing under the laws of the State of Delaware (“Magenta”) and MAGENTA VIRAL PRODUCTION, INC., a corporation organized and in good standing under the laws of the State of Delaware (“Magenta Viral”; together with the Company, MA BioServices and Magenta, each a “Borrower” and collectively, the “Borrowers”) and BANK OF AMERICA, N.A

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