0000950123-15-006621 Sample Contracts

LICENSE PAYMENT AGREEMENT
License Payment Agreement • May 19th, 2015 • ProNAi Therapeutics Inc • Pharmaceutical preparations

THIS LICENSE PAYMENT AGREEMENT (this “Agreement”) is made effective as of April 14, 2014 (the “Effective Date”), by and among Novosom Verwaltungs GmbH, a German corporation with a corporate address of Weinbergweg 22, 06120 Halle, Germany (“Novosom”), and ProNAi Therapeutics, Inc., a Delaware corporation, with a corporate address of 46701 Commerce Center Drive, Plymouth, MI 48170 (“ProNAi”). ProNAi and Novosom are collectively referred to herein as the “Parties” and each of them as a “Party.”

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ARTICLE 1 - FUNDAMENTAL LEASE PROVISIONS
Lease • May 19th, 2015 • ProNAi Therapeutics Inc • Pharmaceutical preparations • Michigan
EXCLUSIVE LICENSE AGREEMENT
Exclusive License Agreement • May 19th, 2015 • ProNAi Therapeutics Inc • Pharmaceutical preparations • Delaware

For clarity each of the above milestone payments shall be paid only once for a particular Licensed Product, regardless if any such Milestone Event is achieved more than once, [***]. Further, if a particular Licensed Product achieves a particular Milestone Event under subclause (i) of the above table without having achieved a previous Milestone Event in such subclause (i), then such previous Milestone Event shall be deemed also achieved, and the Milestone Payment associated with such Milestone Event shall then be paid with the achievement of the subsequent

SECOND LICENSE AMENDMENT AND CONSENT TO TERMINATION
Purchase Agreement • May 19th, 2015 • ProNAi Therapeutics Inc • Pharmaceutical preparations

This Amendment and Agreement (“Amendment”), dated April 14, 2014 (the “Effective Date”), is made by and among Marina Biotech, Inc., a Delaware corporation with a place of business at 7 Times Square, 40th Floor, New York, NY 10028, Attention: Stephen M. Goodman (“Marina”), ProNAi Therapeutics, Inc., a Delaware corporation, with a corporate address of 46701 Commerce Center Drive, Plymouth, MI 48107 (“ProNAi”).

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