0000950123-10-102733 Sample Contracts

EMPLOYMENT AGREEMENT
Employment Agreement • November 9th, 2010 • Santarus Inc • Pharmaceutical preparations • California

THIS EMPLOYMENT AGREEMENT (this “Agreement”) is entered into by and between Santarus, Inc., a Delaware corporation (the “Company”), and Mark Totoritis (“Executive”), and shall be effective as of September 10, 2010 (the “Effective Date”).

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License Agreement Pharming Group N.V. AND Pharming Intellectual Property b.v. AND Santarus, Inc. September 10, 2010
License Agreement • November 9th, 2010 • Santarus Inc • Pharmaceutical preparations • New York

This LICENSE AGREEMENT (the “Agreement”) is made effective as of the 10th day of September, 2010 (the “Effective Date”) by and between PHARMING GROUP N.V., a Dutch corporation having its principal place of business at Darwinweg 24, 2333 CR Leiden, The Netherlands, on behalf of itself and each of its Affiliates, including Pharming Intellectual Property B.V. and Pharming Technologies B.V. (“Pharming”) and SANTARUS, INC., a Delaware corporation with its principal place of business at 3721 Valley Centre Drive, Suite 400, San Diego, California 92130 (“Santarus”). Pharming and Santarus are sometimes referred to herein individually as a “Party” and collectively as the “Parties.”

AMENDMENT TO LICENSE AGREEMENT
License Agreement • November 9th, 2010 • Santarus Inc • Pharmaceutical preparations • California

THIS AMENDMENT TO LICENSE AGREEMENT, dated as of September 10, 2010 (the “Amendment”), is entered into among Biogen Idec MA Inc. (“Biogen Idec”), Covella Pharmaceuticals, Inc. (“Covella”) and Santarus, Inc. (“Santarus”) (hereinafter collectively, the “Parties”).

AGREEMENT AND PLAN OF MERGER by and among SANTARUS, INC., SAN ACQUISITION CORP., COVELLA PHARMACEUTICALS, INC. and LAWRENCE C. FRITZ as the STOCKHOLDER REPRESENTATIVE September 10, 2010
Agreement and Plan of Merger • November 9th, 2010 • Santarus Inc • Pharmaceutical preparations • Delaware

This AGREEMENT AND PLAN OF MERGER (this “Agreement”), dated as of September 10, 2010, is entered into by and among Santarus, Inc., a Delaware corporation (“Parent”), SAN Acquisition Corp., a Delaware corporation and wholly owned subsidiary of Parent (“Merger Sub”), Covella Pharmaceuticals, Inc., a Delaware corporation (the “Company”) and Dr. Fritz, acting in his capacity as stockholder representative in connection with the transactions contemplated by this Agreement (the “Stockholder Representative”). Hereafter, Parent, the Company and the Stockholder Representative shall sometimes be referred to as the “parties.”

Manufacturing Services Agreement May 26, 2010
Manufacturing Services Agreement • November 9th, 2010 • Santarus Inc • Pharmaceutical preparations • Ohio

THIS AGREEMENT WITNESSES THAT in consideration of the rights conferred and the obligations assumed herein, and for other good and valuable consideration (the receipt and sufficiency of which are acknowledged by each party), and intending to be legally bound the parties agree as follows:

DISTRIBUTION AND LICENSE AGREEMENT
Distribution and License Agreement • November 9th, 2010 • Santarus Inc • Pharmaceutical preparations • New York

This DISTRIBUTION AND LICENSE AGREEMENT (this “Agreement”) is made as of September 3, 2010 (the “Effective Date”), by and among VeroScience, LLC, a Delaware limited liability company (“VeroScience”), S2 Therapeutics, Inc. f/k/a Wythe Therapeutics, Inc., a Tennessee corporation (“S2”), and Santarus, Inc., a Delaware corporation (“Santarus”). Each of VeroScience, S2 and Santarus is referred to herein individually as a “party” and collectively as the “parties.”

AMENDMENT NO. 2 TO OTC LICENSE AGREEMENT
Otc License Agreement • November 9th, 2010 • Santarus Inc • Pharmaceutical preparations

This Amendment No. 2 (the “Amendment”) to the OTC License Agreement dated October 17, 2006, between Schering-Plough Healthcare Products, Inc. (“MCC”) and Santarus, Inc. (“Santarus”), as amended, (the “License”) is made as of August 6, 2010.

ASSIGNMENT AND ASSUMPTION AGREEMENT
Assignment and Assumption Agreement • November 9th, 2010 • Santarus Inc • Pharmaceutical preparations • New York

This ASSIGNMENT AND ASSUMPTION AGREEMENT (this “Agreement”), is made as of September 3, 2010 (the “Effective Date”), by and between S2 Therapeutics, Inc. f/k/a Wythe Therapeutics, Inc., a Tennessee corporation (“S2”), and Santarus, Inc., a Delaware corporation (“Santarus”). Each of S2 and Santarus is referred to herein individually as a “party” and collectively as the “parties.”

LICENSE AGREEMENT
License Agreement • November 9th, 2010 • Santarus Inc • Pharmaceutical preparations • California

THIS LICENSE AGREEMENT (“Agreement”) dated as of January 22, 2009 (“Effective Date”), is entered into between Covella Pharmaceuticals, Inc., a Delaware corporation, having its principal place of business at P.O. Box 676150, 14530 Calle Carla, Rancho Santa Fe, CA 92067 (“Covella”) and Biogen Idec MA Inc., a Massachusetts corporation, having its principal executive offices at 14 Cambridge Centre, Cambridge, MA 02142 (“Biogen Idec”).

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