0000950123-10-030260 Sample Contracts

Cypress Bioscience, Inc. 2009 Equity Incentive Plan [Form] Restricted Stock Unit Agreement
Restricted Stock Unit Agreement • March 31st, 2010 • Cypress Bioscience Inc • Biological products, (no disgnostic substances) • California

Pursuant to the Restricted Stock Unit Grant Notice (“Grant Notice”) and this Restricted Stock Unit Agreement and in consideration of your services, Cypress Bioscience, Inc. (the “Company”) has awarded you a Restricted Stock Unit Award (the “Award”) under its 2009 Equity Incentive Plan (the “Plan”). Your Award is granted to you effective as of the Date of Grant set forth in the Grant Notice for this Award. This Restricted Stock Unit Award Agreement shall be deemed to be agreed to by the Company and you upon the signing by you of the Restricted Stock Unit Grant Notice to which it is attached. Defined terms not explicitly defined in this Restricted Stock Unit Agreement shall have the same meanings given to them in the Plan. In the event of any conflict between the terms in this Restricted Stock Unit Agreement and the Plan, the terms of the Plan shall control. The details of your Award, in addition to those set forth in the Grant Notice and the Plan, are as follows.

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AMENDMENT TO AMENDED AND RESTATED EMPLOYMENT AGREEMENT
Employment Agreement • March 31st, 2010 • Cypress Bioscience Inc • Biological products, (no disgnostic substances) • California

This Amendment (this “Amendment”) to the Amended and Restated Employment Agreement (“Employment Agreement”) entered into as of December 31, 2008, by and between CYPRESS BIOSCIENCE, INC. (the “Company”) and JAY D. KRANZLER, M.D., Ph.D. (the “Employee”), is entered into as of December 24, 2009. Capitalized terms used but not assigned a meaning in this Amendment shall have the meanings assigned to such terms in the Employment Agreement.

SECOND AMENDMENT TO LEASE
Lease • March 31st, 2010 • Cypress Bioscience Inc • Biological products, (no disgnostic substances)

THIS SECOND AMENDMENT TO LEASE (this “Second Amendment”) is made as of December 21, 2009, by and between ARE-SD REGION NO. 20, LLC, a Delaware limited liability company (“Landlord”), and CYPRESS BIOSCIENCE, INC., a Delaware corporation (“Tenant”).

FOURTH AMENDMENT
Fourth Amendment • March 31st, 2010 • Cypress Bioscience Inc • Biological products, (no disgnostic substances)

THIS FOURTH AMENDMENT (the “Amendment”) is made and entered into as of December 29, 2009, by and between UTC PROPERTIES LLC, a Delaware limited liability company, (“Landlord”) and CYPRESS BIOSCIENCE, INC., a Delaware corporation (“Tenant”).

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