Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions. AMENDED AND RESTATED STRATEGIC COLLABORATION AND LICENSE AGREEMENTStrategic Collaboration and License Agreement • August 7th, 2009 • Alnylam Pharmaceuticals, Inc. • Pharmaceutical preparations • Delaware
This Amended and Restated Strategic Collaboration and License Agreement (the “Agreement”) is executed this April 28, 2009 (the “Restatement Date”), between Isis Pharmaceuticals, Inc., a Delaware corporation having an address at 1896 Rutherford Road, Carlsbad, CA 92008 (“Isis”) and Alnylam Pharmaceuticals, Inc., a Delaware corporation having an address at 300 Third Street, Cambridge, Cambridge, MA 02142 (together with its wholly owned subsidiaries Alnylam U.S., Inc., a Delaware corporation, and Alnylam Europe AG, a company organized under the laws of Germany, “Alnylam”). Isis and Alnylam may be referred to herein as the “Parties,” or each individually as a “Party.”
SECOND AMENDMENT TO LEASELease • August 7th, 2009 • Alnylam Pharmaceuticals, Inc. • Pharmaceutical preparations
