0000950123-09-003848 Sample Contracts

Date] [Name] [Title] The Medicines Company 8 Campus Drive Parsippany, NJ 07054 Dear [Name]:
Medicines Co /De • March 2nd, 2009 • Pharmaceutical preparations

This letter agreement amends and restates in its entirety the letter agreement between you and The Medicines Company (the “Company”) dated August 17, 2006 regarding the subject matter hereof.

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FIRST AMENDMENT TO LEASE
Lease • March 2nd, 2009 • Medicines Co /De • Pharmaceutical preparations

THIS FIRST AMENDMENT TO LEASE (the “Amendment”) is made as of the 21st day of October, 2008 between 8 SYLVAN WAY, LLC, a New Jersey limited liability company, having an office at 15 Maple Avenue, Morristown, New Jersey 07960 (“Landlord”) and THE MEDICINES COMPANY, a Delaware corporation (“Tenant”).

AMENDMENT NO. 2 TO LICENSE AGREEMENT
License Agreement • March 2nd, 2009 • Medicines Co /De • Pharmaceutical preparations

THIS AMENDMENT NO. 2 (“Amendment No. 2”) to the AGREEMENT (as defined below) is entered into as of 22 October, 2008 by and between ASTRAZENECA AB, a company incorporated under the laws of Sweden with its registered office at SE-151 85 Södertälje, Sweden (“ASTRAZENECA”) and The MEDICINES COMPANY, a company incorporated under the laws of Delaware with its registered office at 8 Campus Drive, Parsippany, New Jersey 07054, United States (“TMC”).

OFFICE LEASE AGREEMENT BETWEEN NORMANDY WALTHAM HOLDINGS, LLC (“LANDLORD”) AND THE MEDICINES COMPANY (“TENANT”)
Office Lease Agreement • March 2nd, 2009 • Medicines Co /De • Pharmaceutical preparations

THIS OFFICE LEASE AGREEMENT (the “Lease”) is made and entered into as October ___, 2008, by and between NORMANDY WALTHAM HOLDINGS, LLC, a Delaware limited liability company (“Landlord”) and THE MEDICINES COMPANY, a Delaware corporation (“Tenant”).

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