TEXT OMITTED AND FILED SEPARATELY "CONFIDENTIAL TREATMENT REQUESTED UNDER 17 C.F.R. SECTIONS 200.80(B)(4), 200.83 AND 240.24b-2." SECURITIES PURCHASE AGREEMENT SECURITIES PURCHASE AGREEMENT (this "Agreement"), dated as of January 14, 2000, between...Securities Purchase Agreement • January 28th, 2000 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • Delaware
TEXT OMITTED AND FILED SEPARATELY "CONFIDENTIAL TREATMENT REQUESTED UNDER 17 C.F.R. SECTIONS 200.80(B)(4), 200.83 AND 240.24B-2." SUBSCRIPTION, JOINT DEVELOPMENT AND OPERATING AGREEMENT ELAN CORPORATION, PLC (ACTING THROUGH ITS DIVISION ELAN...Operating Agreement • January 28th, 2000 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • New York
1 EXHIBIT 10.5 ISIS PHARMACEUTICALS, INC. REGISTRATION RIGHTS AGREEMENT THIS REGISTRATION RIGHTS AGREEMENT (the "Agreement") is made as of January 14, 2000 by and between ISIS PHARMACEUTICALS, INC., a Delaware corporation (the "Company"), and ELAN...Registration Rights Agreement • January 28th, 2000 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • Delaware
BETWEENLicense Agreement • January 28th, 2000 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • New York
1 EXHIBIT 10.6 HEPASENSE LTD. REGISTRATION RIGHTS AGREEMENT THIS REGISTRATION RIGHTS AGREEMENT (the "Agreement") is made as of January 14, 2000, by and among HEPASENSE LTD., a Bermuda exempted limited liability company (the "Company"), ISIS...Registration Rights Agreement • January 28th, 2000 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • New York
1 EXHIBIT 10.4 Exhibit F to Securities Purchase Agreement THIS WARRANT AND THE SHARES OF COMMON STOCK ISSUABLE UPON EXERCISE HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND MAY NOT UNDER ANY CIRCUMSTANCES BE SOLD,...Isis Pharmaceuticals Inc • January 28th, 2000 • Pharmaceutical preparations • Delaware
