SECOND AMENDMENT TO RESEARCH COLLABORATION AND LICENSE AGREEMENTResearch Collaboration and License Agreement • August 14th, 2002 • Isis Pharmaceuticals Inc • Pharmaceutical preparations
This second amendment ("Amendment") to the Research Collaboration And License Agreement is made and effective this 19th day of April, 2002 between Merck & Co., Inc., a corporation organized and existing under the laws of New Jersey ("Merck") and Isis Pharmaceuticals, Inc., a corporation organized and existing under the laws of Delaware ("Isis") together referred to as the "Parties".
AMENDMENT NO. 1 TO SECURITIES PURCHASE AGREEMENTSecurities Purchase Agreement • August 14th, 2002 • Isis Pharmaceuticals Inc • Pharmaceutical preparations
This Amendment No. 1 to Securities Purchase Agreement (the "Amendment"), is effective as of April 25, 2002 ("Effective Date") between Isis Pharmaceuticals, Inc., a Delaware corporation ("Isis"), and Elan International Services, Ltd., a Bermuda exempted limited liability company ("EIS") and a wholly-owned subsidiary of Elan Corporation, plc, an Irish public limited company.
AMENDED AND RESTATED COLLABORATION AGREEMENT BETWEEN ELI LILLY AND COMPANY AND ISIS PHARMACEUTICALS, INC. June 17, 2002Collaboration Agreement • August 14th, 2002 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • New York
THIS AMENDED AND RESTATED COLLABORATION AGREEMENT (the "Agreement") is entered into and effective as of June 17, 2002 (the "Restatement Date"), by and between ELI LILLY AND COMPANY, a corporation organized and existing under the laws of Indiana and its Affiliates (together "Lilly"), and ISIS PHARMACEUTICALS, INC., a corporation organized and existing under the laws of Delaware ("Isis").
