0000874015-24-000116 Sample Contracts

INDEMNITY AGREEMENT
Indemnity Agreement • February 21st, 2024 • Ionis Pharmaceuticals Inc • Pharmaceutical preparations • Delaware

THIS INDEMNITY AGREEMENT (the “Agreement”) is made and entered into this [DAY] day of [MONTH], [YEAR] by and between Ionis Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and [DIRECTOR/OFFICER NAME] (“Agent”).

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License Agreement By and Between Ionis Pharmaceuticals, Inc. and Otsuka Pharmaceutical Co., Ltd.
License Agreement • February 21st, 2024 • Ionis Pharmaceuticals Inc • Pharmaceutical preparations • New York

This License Agreement (this “Agreement”) is made and entered into as of December 15, 2023 (the “Effective Date”) between Ionis Pharmaceuticals, Inc., a Delaware corporation, having its principal place of business at 2855 Gazelle Court, Carlsbad CA 92010 USA (“Ionis”), and Otsuka Pharmaceutical Co., Ltd., a company organized and existing under the laws of Japan, having a place of business at 2-9, Kanda Tsukasa-machi, Chiyoda-ku, Tokyo 101-8535, Japan (“Otsuka”). Ionis and Otsuka may be referred to in this Agreement individually as a “Party” and collectively as the “Parties.” Capitalized terms used in this Agreement, whether used in the singular or the plural, have the meaning set forth in Appendix 1 (Definitions). All attached appendices and schedules are a part of this Agreement.

FIRST AMENDMENT TO AMENDED AND RESTATED LEASE
Lease • February 21st, 2024 • Ionis Pharmaceuticals Inc • Pharmaceutical preparations

THIS FIRST AMENDMENT TO AMENDED AND RESTATED LEASE (this “Amendment”) is entered into as of November 6, 2023, by and between LOTS 21 & 22 OWNER (DE) LLC, a Delaware limited liability company (“Landlord”), and IONIS PHARMACEUTICALS, INC., a Delaware corporation (“Tenant”).

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