Onconetix, Inc. Sample Contracts

COMMON STOCK PURCHASE WARRANT BLUE WATER VACCINES, INC.
Common Stock Purchase Warrant • January 6th, 2022 • Blue Water Vaccines Inc. • Pharmaceutical preparations • New York

THIS COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, _____________ or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (the “Initial Exercise Date”) and on or prior to 5:00 p.m. (New York City time) on [_____], 20__1 (the “Termination Date”) but not thereafter, to subscribe for and purchase from Blue Water Vaccines, Inc., a Delaware corporation (the “Company”), up to [___] shares (as subject to adjustment hereunder, the “Warrant Shares”) of Common Stock. The purchase price of one share of Common Stock under this Warrant shall be equal to the Exercise Price, as defined in Section 2(b). This Warrant shall initially be issued and maintained in the form of a security held in book-entry form and the Depository Trust Company or its nominee (“DTC”) shall initially be the sole registered holder of this Warrant, subject to a Holder’

FORM OF REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • August 11th, 2022 • Blue Water Vaccines Inc. • Pharmaceutical preparations

This Registration Rights Agreement (this “Agreement”) is made and entered into as of August 9, 2022, by and between Blue Water Vaccines Inc., a Delaware corporation (the “Company”), and each of the several purchasers signatory hereto (each such purchaser, a “Purchaser” and, collectively, the “Purchasers”).

FORM OF SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • August 11th, 2022 • Blue Water Vaccines Inc. • Pharmaceutical preparations • New York

This Securities Purchase Agreement (this “Agreement”) is dated as of August 9, 2022, between Blue Water Vaccines Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”).

INDEMNIFICATION AGREEMENT
Indemnification Agreement • October 8th, 2021 • Blue Water Vaccines Inc. • Pharmaceutical preparations • Delaware

THIS INDEMNIFICATION AGREEMENT (the “Agreement”) is made and entered into as of __, 202[ ] between Blue Water Vaccines Inc., a Delaware corporation (the “Company”), and (“Indemnitee”).

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • October 3rd, 2024 • Onconetix, Inc. • Pharmaceutical preparations • Delaware

This SECURITIES PURCHASE AGREEMENT (the “Agreement”), dated as of October 2, 2024, is by and among Onconetix, Inc., a Delaware corporation with offices located at 201 E. Fifth Street, Suite 1900 Cincinnati, OH 45202 (the “Company”), and each of the investors listed on the Schedule of Buyers attached hereto (individually, a “Buyer” and collectively, the “Buyers”).

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • October 3rd, 2024 • Onconetix, Inc. • Pharmaceutical preparations

This REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of October 2, 2024, is by and among Onconetix, Inc., a Delaware corporation with offices located at 201 E. Fifth Street, Suite 1900 Cincinnati, OH 45202 (the “Company”), and the undersigned buyers (each, a “Buyer,” and collectively, the “Buyers”).

BLUE WATER VACCINES, INC. and CONTINENTAL STOCK TRANSFER & TRUST COMPANY, as Warrant Agent Warrant Agency Agreement Dated as of [ ] __, 2022 WARRANT AGENCY AGREEMENT
Warrant Agency Agreement • January 6th, 2022 • Blue Water Vaccines Inc. • Pharmaceutical preparations • California

WARRANT AGENCY AGREEMENT, dated as of [ ] __, 2022 (“Agreement”), between Blue Water Vaccines, Inc., a corporation organized under the laws of the State of Delaware (the “Company”), and Continental Stock Transfer & Trust Company., a corporation organized under the laws of [ ] (the “Warrant Agent”).

AT THE MARKET OFFERING AGREEMENT March 29, 2023
At the Market Offering Agreement • March 29th, 2023 • Blue Water Vaccines Inc. • Pharmaceutical preparations • New York

Blue Water Vaccines Inc., a corporation organized under the laws of Delaware (the “Company”), confirms its agreement (this “Agreement”) with H.C. Wainwright & Co., LLC (the “Manager”) as follows:

BLUE WATER VACCINES, INC. UNDERWRITING AGREEMENT
Underwriting Agreement • December 29th, 2021 • Blue Water Vaccines Inc. • Pharmaceutical preparations • New York

The undersigned, Blue Water Vaccines, Inc., a Delaware corporation (the “Company”), hereby confirms its agreement (this “Agreement”) to issue and sell to the underwriter or underwriters, as the case may be, named in Schedule I hereto (each, an “Underwriter” and, collectively, the “Underwriters;”), for whom Maxim Group LLC is acting as representative (in such capacity, the “Representative”), an aggregate of [____] units (the “Firm Units” or “Units”) of the Company’s securities, and, at the election of the Representative, up to an additional [_________] Option Shares (as defined herein and collectively with the shares of Common Stock underlying the Firm Units, the “Shares”), and/or up to an additional [_____] Option Warrants (as defined herein and collectively with warrants underlying the Firm Units, the “Warrants”). Each Unit consists of one share of the Company’s common stock, par value $0.00001 per share (the “Common Stock”) and one Warrant. Each Warrant entitles the holder to purchas

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • December 11th, 2024 • Onconetix, Inc. • Pharmaceutical preparations

This REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of October 2, 2024, is by and between Keystone Capital Partners, LLC (the “Investor”), and Onconetix, Inc., a Delaware corporation (the “Company”).

COMMON STOCK PURCHASE AGREEMENT Dated as of October 2, 2024 by and among ONCONETIX, INC., and
Common Stock Purchase Agreement • December 11th, 2024 • Onconetix, Inc. • Pharmaceutical preparations • New York

This COMMON STOCK PURCHASE AGREEMENT is made and entered into as of October 1, 2024 (this “Agreement”), by and among Keystone Capital Partners, LLC, a Delaware limited liability company, (the “Investor”), and Onconetix, Inc., a Delaware corporation (the “Company”).

FORM OF PRE-FUNDED COMMON STOCK PURCHASE WARRANT Blue Water Vaccines Inc.
Pre-Funded Warrant Agreement • August 11th, 2022 • Blue Water Vaccines Inc. • Pharmaceutical preparations

THIS PRE-FUNDED COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, _____________ or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date set forth above (the “Initial Exercise Date”) and until this Warrant is exercised in full (the “Termination Date”) but not thereafter, to subscribe for and purchase from Blue Water Vaccines Inc., a Delaware corporation (the “Company”), up to ______ shares (as subject to adjustment hereunder, the “Warrant Shares”) of the Company’s Common Stock. The purchase price of one share of Common Stock under this Warrant shall be equal to the Exercise Price, as defined in Section 2(b).

BLUE WATER VACCINES, INC. UNDERWRITING AGREEMENT
Underwriting Agreement • February 8th, 2022 • Blue Water Vaccines Inc. • Pharmaceutical preparations • New York

The undersigned, Blue Water Vaccines, Inc., a Delaware corporation (the “Company”), hereby confirms its agreement (this “Agreement”) to issue and sell to the underwriter or underwriters, as the case may be, named in Schedule I hereto (each, an “Underwriter” and, collectively, the “Underwriters;”), for whom Boustead Securities, LLC is acting as representative (in such capacity, the “Representative”), an aggregate of 2,222,222 shares (the “Shares”) of common stock of the Company, par value $0.0001 per share (the “Common Stock”) The offering and sale of the Shares contemplated by this Agreement is referred to herein as the “Offering.”

EMPLOYMENT AGREEMENT
Employment Agreement • October 10th, 2023 • Blue Water Biotech, Inc. • Pharmaceutical preparations • Delaware

This EMPLOYMENT AGREEMENT (the “Agreement”) is made and entered into as of October 4, 2023 by and between Blue Water Biotech, Inc., a Delaware corporation (the “Company”) and Dr. Neil J. Campbell (“Executive”).

FORM OF Placement Agent Warrant Blue Water Vaccines Inc.
Placement Agreement • August 11th, 2022 • Blue Water Vaccines Inc. • Pharmaceutical preparations

THIS Placement Agent Warrant (the “Warrant”) certifies that, for value received, _____________ or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date set forth above (the “Initial Exercise Date”) and on or prior to 5:00 p.m. (New York City time) on August 11, 2027 (the “Termination Date”) but not thereafter, to subscribe for and purchase from Blue Water Vaccines Inc., a Delaware corporation (the “Company”), up to ______ shares (as subject to adjustment hereunder, the “Warrant Shares”) of the Company’s Common Stock. The purchase price of one share of Common Stock under this Warrant shall be equal to the Exercise Price, as defined in Section 2(b). This Warrant is being issued by the Company pursuant to that certain engagement letter, dated as of August 6, 2022, by and between the Company and H.C. Wainwright & Co., LLC.

FORM OF PREFERRED INVESTMENT OPTION Blue Water Vaccines Inc.
Preferred Investment Agreement • August 11th, 2022 • Blue Water Vaccines Inc. • Pharmaceutical preparations

THIS PREFERRED INVESTMENT OPTION (the “Preferred Investment Option”) certifies that, for value received, _____________ or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date set forth above (the “Initial Exercise Date”) and on or prior to 5:00 p.m. (New York City time) on August 11, 2027 (the “Termination Date”) but not thereafter, to subscribe for and purchase from Blue Water Vaccines Inc., a Delaware corporation (the “Company”), up to ______ shares (as subject to adjustment hereunder, the “Preferred Investment Option Shares”) of the Company’s Common Stock. The purchase price of one share of Common Stock under this Preferred Investment Option shall be equal to the Exercise Price, as defined in Section 2(b).

PREFERRED INVESTMENT OPTION Onconetix, Inc.
Preferred Investment Option • July 11th, 2024 • Onconetix, Inc. • Pharmaceutical preparations • New York

THIS PREFERRED INVESTMENT OPTION (the “Preferred Investment Option”) certifies that, for value received, _____________ or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the Stockholder Approval Date (as defined below) (the “Initial Exercise Date”) and on or prior to 5:00 p.m. (New York City time) on the date that is [the five (5) year anniversary]/[twenty-four (24) month anniversary]1 of the Stockholder Approval Date, provided that, if such date is not a Trading Day, the date that is the immediately following Trading Day (the “Termination Date”), but not thereafter, to subscribe for and purchase from Onconetix, Inc., a Delaware corporation (the “Company”), up to ______ shares (as subject to adjustment hereunder, the “Preferred Investment Option Shares”) of the Company’s Common Stock. The purchase price of one share of Common Stock under this Preferred Investment Option s

INDEMNIFICATION AGREEMENT
Indemnification Agreement • October 10th, 2023 • Blue Water Biotech, Inc. • Pharmaceutical preparations • Delaware

This Indemnification Agreement (“Agreement”) is entered into as of the [__] day of [__] by and between Blue Water Biotech, Inc., (the “Company”), and [__] (“Indemnitee”).

BLUE WATER VACCINES INC., as ISSUER and [ ], as INDENTURE TRUSTEE INDENTURE Dated as of [ ]
Indenture • March 9th, 2023 • Blue Water Vaccines Inc. • Pharmaceutical preparations • New York

Each party agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders of the Securities issued under this Indenture.

ASSET PURCHASE AGREEMENT BY AND BETWEEN BLUE WATER VACCINES INC. AND VERU INC. DATED AS OF APRIL 19, 2023
Asset Purchase Agreement • April 20th, 2023 • Blue Water Vaccines Inc. • Pharmaceutical preparations • Delaware

THIS ASSET PURCHASE AGREEMENT (this “Agreement”) is made and entered into as of April 19, 2023 by and between BLUE WATER VACCINES INC., a Delaware corporation (“Buyer”), and VERU INC., a Wisconsin corporation (“Seller”).

EMPLOYMENT AGREEMENT between
Employment Agreement • April 11th, 2024 • Onconetix, Inc. • Pharmaceutical preparations
FORBEARANCE AGREEMENT
Forbearance Agreement • April 26th, 2024 • Onconetix, Inc. • Pharmaceutical preparations • Delaware

THIS FORBEARANCE AGREEMENT (this “Agreement”) is entered into as of this 24th day of April, 2024 (the “Effective Date”), by and among Onconetix, Inc., a Delaware corporation (“Borrower”), and Veru Inc., a Wisconsin corporation (“Holder”). Capitalized terms not otherwise defined herein shall have the meanings given to such terms in the Promissory Notes (as defined below).

EXCLUSIVE LICENSE AGREEMENT
Exclusive License Agreement • November 29th, 2021 • Blue Water Vaccines Inc. • Pharmaceutical preparations • Ohio

THIS EXCLUSIVE LICENSE AGREEMENT (the “Agreement”) is made and effective as of June , 2021 (the Effective Date”) by and between Blue Water Vaccines ___________________________________, having a principal place of business at 201 E Fifth Street, Suite 1900 Cincinnati, OH 45202 (“Company”), and Children’s Hospital Medical Center, d/b/a Cincinnati Children’s Hospital Medical Center (“CHMC”), having a principal place of business at 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA.

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • July 29th, 2026 • Onconetix, Inc. • Pharmaceutical preparations • Delaware

This SECURITIES PURCHASE AGREEMENT (the “Agreement”), dated as of July __, 2026, is by and among Onconetix, Inc., a Delaware corporation with offices located at 201 E. Fifth Street, Suite 1900 Cincinnati, OH 45202 (the “Company”), and each of the investors listed on the Schedule of Buyers attached hereto (individually, a “Buyer” and collectively, the “Buyers”).

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • October 3rd, 2025 • Onconetix, Inc. • Pharmaceutical preparations • Delaware

This SECURITIES PURCHASE AGREEMENT (the “Agreement”), dated as of October 1, 2025, is by and among Onconetix, Inc., a Delaware corporation with offices located at 201 E. Fifth Street, Suite 1900 Cincinnati, OH 45202 (the “Company”), and each of the investors listed on the Schedule of Buyers attached hereto (individually, a “Buyer” and collectively, the “Buyers”).

SETTLEMENT AGREEMENT AND RELEASE
Settlement Agreement • September 26th, 2025 • Onconetix, Inc. • Pharmaceutical preparations • Delaware

This SETTLEMENT AGREEMENT AND RELEASE (“Agreement”) is made and entered into by and between Onconetix, Inc., a Delaware corporation (the “Company”) and Veru, Inc., a Wisconsin Corporation (“Veru”) on September 22, 2025 (the “Effective Date”). Each of the Company and Veru is a “Party” under this Agreement, and collectively they constitute the “Parties”.

STOCKHOLDER SUPPORT AGREEMENT
Stockholder Support Agreement • December 21st, 2023 • Onconetix, Inc. • Pharmaceutical preparations

This STOCKHOLDER SUPPORT AGREEMENT (this “Agreement”) is made and entered into as of December 15, 2023, by and among Blue Water Biotech, Inc., a Delaware corporation (“Buyer”), Proteomedix AG, a Swiss Company (the “Company”), and the stockholders of the Company whose names appear on the signature pages of this Agreement (each, a “Company Stockholder”, and collectively, the “Company Stockholders”).

TERMINATION AND RELEASE AGREEMENT
Termination and Release Agreement • September 26th, 2025 • Onconetix, Inc. • Pharmaceutical preparations • Delaware

THIS TERMINATION AND RELEASE AGREEMENT, dated as of September 17, 2025 (this “Agreement”), is entered into by and among (i) Onconetix, Inc., a Delaware corporation (“Parent”), (ii) Onconetix Merger Sub, Inc., a Delaware corporation and a direct, wholly owned subsidiary of Parent (“Merger Sub”), (iii) Andrew Oakley, in the capacity as Parent Representative in accordance with the terms and conditions of the Merger Agreement (the “Parent Representative”), and (iv) Ocuvex Therapeutics, Inc., a Delaware corporation (the “Company”). Capitalized terms used but not defined herein shall have the meanings ascribed to such terms in the Merger Agreement.

Contract
Share Exchange Agreement • September 5th, 2024 • Onconetix, Inc. • Pharmaceutical preparations

Onconetix, Inc. (formerly known as Blue Water Biotech, Inc. and Blue Water Vaccines Inc.) (the “Company” or “Onconetix”) was formed on October 26, 2018, and is a commercial stage biotechnology company focused on the research, development, and commercialization of innovative solutions for men’s health and oncology On December 15, 2023, Onconetix, entered into a Share Exchange Agreement (the “Share Exchange Agreement”), by and among (i) Onconetix, (ii) Proteomedix AG, a Swiss Company (“Proteomedix”), (iii) each of the holders of outstanding capital stock or Proteomedix Convertible Securities (other than Proteomedix Stock Options) named therein (collectively, the “Sellers”) and (iv) Thomas Meier, in the capacity as the representative of Sellers in accordance with the terms and conditions of the Share Exchange Agreement.

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • July 29th, 2026 • Onconetix, Inc. • Pharmaceutical preparations

This REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of ___, 2026, is by and among Onconetix, Inc., a Delaware corporation with offices located at 201 E. Fifth Street, Suite 1900 Cincinnati, OH 45202 (the “Company”), and the undersigned buyers (each, a “Buyer,” and collectively, the “Buyers”).

ASSET PURCHASE AGREEMENT by and among WraSer, LLC, Xspire Pharma, LLC, Legacy- Xspire Holdings, LLC and Blue Water Biotech, Inc. Dated as of June 13, 2023
Asset Purchase Agreement • June 14th, 2023 • Blue Water Biotech, Inc. • Pharmaceutical preparations • Delaware

THIS ASSET PURCHASE AGREEMENT (this “Agreement”) is made and executed as of June 13, 2023 (the “Execution Date”), by and between WraSer, LLC, a Mississippi limited liability company and Xspire Pharma, LLC, a Mississippi limited liability company (collectively, the “Seller”), Legacy-Xspire Holdings, LLC, a Delaware limited liability company and the parent company of the Seller (“Parent”) and Blue Water Biotech, Inc., a Delaware corporation (“Buyer”). Seller and Buyer are sometimes referred to herein individually as a “Party” and collectively as the “Parties.”

SPONSORED RESEARCH AGREEMENT
Sponsored Research Agreement • July 25th, 2022 • Blue Water Vaccines Inc. • Pharmaceutical preparations • Ohio

THIS SPONSORED RESEARCH AGREEMENT is made and effective as of June 30, 2022 (the “Effective Date”) by and between Children’s Hospital Medical Center, d/b/a Cincinnati Children’s Hospital Medical Center (“CHMC”) located at 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, and Blue Water Vaccines, located at 201 E. Fifth Street, Suite 1900, Cincinnati, Ohio 45202, (“Sponsor”).

Onconetix, Inc. Consulting Agreement
Consulting Agreement • February 28th, 2025 • Onconetix, Inc. • Pharmaceutical preparations

This Consulting Agreement (the “Agreement”), shall be effective as of February 28, 2025 (the “Effective Date”), and is entered into by Onconetix, Inc., with a business address at 201 E. Fifth Street, Suite 1900, Cincinnati, Ohio 45202 (the “Company”), and James Sapirstein (the “Consultant”).

AMENDMENT TO EMPLOYMENT AGREEMENT between
Employment Agreement • April 11th, 2024 • Onconetix, Inc. • Pharmaceutical preparations

The parties have entered into an employment agreement dated November 23, 2011 (the “Employment Agreement”) and a corresponding Confidentiality and Assignment Agreement dated November 23, 2011 (the “Assignment Agreement”). The parties have further concluded a:n amendment to the Employment Agreement dated October 16, 2020 (the “Amendment No. 1”).

WAIVER AND AMENDMENT NO. 1 TO FORBEARANCE AGREEMENT
Forbearance Agreement • December 3rd, 2024 • Onconetix, Inc. • Pharmaceutical preparations

This LIMITED WAIVER AND AMENDMENT NO. 1, dated as of November 26, 2024 (“Limited Waiver”), is made by ONCONETIX, INC (the “Company”) and VERU INC. (the “Holder”).