Common use of TOTAL SUBSCRIPTION AMOUNT Clause in Contracts

TOTAL SUBSCRIPTION AMOUNT. (Sum of (1)(a) and (2)(a)): $ 69,135.00 Tax ID No.: [Redacted] Address for Notice: 0 Xxxxxxx Xxxxxx, 00xx Xxxxx Xxx Xxxxxxxxx, XX 00000 Telephone No.: [Redacted] Facsimile No.: [Redacted] E-mail Address: [Redacted] Attention: Xxxxx Xxx Delivery Instructions (if different than left) c/o: The Depository Trust Company Street: 000 Xxxxxxxxxx Xxxx., 0xx Xxxxx Xxxx/Xxxxx/Xxx: Xxxxxx Xxxx, XX 00000 Attention: [Redacted] Telephone No.: [Redacted] PURCHASER: MSI BVF SPV, LLC By: BVF Partners L.P., attorney-in-fact By: BVF, Inc., General Partner By: /s/ Xxxx Xxxxxxx Name: Xxxx Xxxxxxx Title: President

TOTAL SUBSCRIPTION AMOUNT. (Sum of (1)(a) and (2)(a)): $ 69,135.00 442,437.50 Tax ID No.: [Redacted] Address for Notice: 0 Xxxxxxx Xxxxxx, 00xx Xxxxx Xxx Xxxxxxxxx, XX 00000 Telephone No.: [Redacted] Facsimile No.: [Redacted] E-mail Address: [Redacted] Attention: Xxxxx Xxx Delivery Instructions (if different than left) c/o: The Depository Trust Company Street: 000 Xxxxxxxxxx Xxxx., 0xx Xxxxx Xxxx/Xxxxx/Xxx: Xxxxxx Xxxx, XX 00000 Attention: [Redacted] Telephone No.: [Redacted] PURCHASER: MSI BVF SPVPURCHASER Biotechnology Value Trading Fund OS, LLC L.P. By: BVF Partners OS Ltd., General Partner By: BVF Partner L.P., attorney-in-fact Sole Member By: BVF, Inc., General Partner By: /s/ Xxxx Xxxxxxx Name: Xxxx Xxxxxxx Title: President

TOTAL SUBSCRIPTION AMOUNT. (Sum of (1)(a) and (2)(a)): $ 69,135.00 116,517.50 Tax ID No.: [Redacted] Address for Notice: 0 Xxxxxxx Xxxxxx, 00xx Xxxxx Xxx Xxxxxxxxx, XX 00000 Telephone No.: [Redacted] Facsimile No.: [Redacted] E-mail Address: [Redacted] Attention: Xxxxx Xxx Delivery Instructions (if different than left) c/o: The Depository Trust Company Street: 000 Xxxxxxxxxx Xxxx., 0xx Xxxxx Xxxx/Xxxxx/Xxx: Xxxxxx Xxxx, XX 00000 Attention: [Redacted] Telephone No.: [Redacted] PURCHASER: MSI BVF SPVInvestment 10, LLC By: BVF Partners Partners, L.P., attorney-in-fact By: BVF, Inc., General Partner By: /s/ Xxxx Xxxxxxx Name: Xxxx Xxxxxxx Title: President

TOTAL SUBSCRIPTION AMOUNT. (Sum of (1)(a) and (2)(a)): $ 69,135.00 653,437.50 Tax ID No.: [Redacted] Address for Notice: 0 Xxxxxxx Xxxxxx, 00xx Xxxxx Xxx Xxxxxxxxx, XX 00000 Telephone No.: [Redacted] Facsimile No.: [Redacted] E-mail Address: [Redacted] Attention: Xxxxx Xxx Delivery Instructions (if different than left) c/o: The Depository Trust Company Street: 000 Xxxxxxxxxx Xxxx., 0xx Xxxxx Xxxx/Xxxxx/Xxx: Xxxxxx Xxxx, XX 00000 Attention: [Redacted] Telephone No.: [Redacted] PURCHASER: MSI BVF SPVBiotechnology Value Fund II, LLC L.P. By: BVF Partners L.P., attorney-in-fact General Partner By: BVF, Inc., General Partner By: /s/ Xxxx Xxxxxxx Name: Xxxx Xxxxxxx Title: President