Simulations. The simulated proporuon of subjects with peak-and trough levels within the target range are displayed in Figure 6. Applying tdm using saliva led to a higher percentage of sub- jects reaching target aчainment compared to no tdm (>75% vs 48%, respecuvely). How- ever, saliva tdm led to a lower percentage of target aчainment compared to blood tdm. Obtaining more than four samples for saliva tdm did not result in increased tdm per- formance. On the contrary, obtaining addiuonal samples at 18h and 1h pre-dose led to a slightly decreased performance (-3% and -4%, respecuvely) compared to the strategy using four samples.
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