Common use of Settlement Upon Conversion Clause in Contracts

Settlement Upon Conversion. 45 Section 5.04. Reserve and Status of Common Stock Issued Upon Conversion. 49 Section 5.05. Adjustments to the Conversion Rate. 50 Section 5.06. Voluntary Adjustments. 60 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 61 Section 5.08. Exchange in Lieu of Conversion. 62 Section 5.09. Effect of Common Stock Change Event. 63 Section 5.10. Responsibility of Trustee. 65 Article 6. Successors 65 Section 6.01. When the Company May Merge, Etc. 65 Section 6.02. Successor Entity Substituted. 66 Section 6.03. Exclusion for Asset Transfers with Wholly Owned Subsidiaries. 66 Article 7. Defaults and Remedies 66 Section 7.01. Events of Default. 66 Section 7.02. Acceleration. 68 Section 7.03. Sole Remedy for a Failure to Report. 69 Section 7.04. Other Remedies. 70 Section 7.05. Waiver of Past Defaults. 70 Section 7.06. Control by Majority. 70 Section 7.07. Limitation on Suits. 71 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 71 Section 7.09. Collection Suit by Trustee. 71 Section 7.10. Trustee May File Proofs of Claim. 72 Section 7.11. Priorities. 72 Section 7.12. Undertaking for Costs. 73 Article 8. Amendments, Supplements and Waivers 73 Section 8.01. Without the Consent of Holders. 73 Section 8.02. With the Consent of Holders. 74 Section 8.03. Notice of Amendments, Supplements and Waivers. 75 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 75 Section 8.05. Notations and Exchanges. 76 Section 8.06. Trustee to Execute Supplemental Indentures. 76

Settlement Upon Conversion. 45 48 Section 5.04. Reserve and Status of Common Stock Ordinary Shares Issued Upon upon Conversion. 49 50 Section 5.05. Adjustments to the Conversion Rate. 50 51 Section 5.06. Voluntary Adjustments. 60 61 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 61 Section 5.08. Exchange in Lieu of ConversionRestriction on Conversions. 62 63 Section 5.09. Effect of Common Stock Ordinary Share Change Event. 63 Section 5.10. Responsibility of Trustee. 65 Article 6. Successors 65 Section 6.01. When the Company May Merge, Etc. 65 Section 6.02. Successor Entity Corporation Substituted. 66 Section 6.03. Exclusion for Asset Transfers with Wholly Owned Subsidiaries. 66 Article 7. Defaults and Remedies 66 Section 7.01. Events of Default. 66 Section 7.02. Acceleration. 68 Section 7.03. Sole Remedy for a Failure to Report. 69 Section 7.04. Other Remedies. 70 Section 7.05. Waiver of Past Defaults. 70 Section 7.06. Control by Majority. 70 Section 7.07. Limitation on Suits. 71 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 71 Section 7.09. Collection Suit by Trustee. 71 Section 7.10. Trustee May File Proofs of Claim. 72 Section 7.11. Priorities. 72 Section 7.12. Undertaking for Costs. 73 Article 8. Amendments, Supplements and Waivers 73 Section 8.01. Without the Consent of Holders. 73 Section 8.02. With the Consent of Holders. 74 Section 8.03. Notice of Amendments, Supplements and Waivers. 75 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 75 Section 8.05. Notations and Exchanges. 76 Section 8.06. Trustee to Execute Supplemental Indentures. 7676 Article 9. Guarantees 76 Section 9.01. Guarantees. 76 Section 9.02. Limitation on Guarantor Liability. 78 Section 9.03. Execution and Delivery of Guarantee. 78 Section 9.04. When Guarantors May Merge, Etc. 78 Section 9.05. Future Guarantors. 79 Section 9.06. Application of Certain Provisions to the Guarantors. 79 Article 10. Satisfaction and Discharge 80 Section 10.01. Termination of Company’s Obligations. 80 Section 10.02. Repayment to Company. 80 Section 10.03. Reinstatement. 80 Article 11. Trustee 81 Section 11.01. Duties of the Trustee. 81 Section 11.02. Rights of the Trustee. 82 Section 11.03. Individual Rights of the Trustee. 83 Section 11.04. Trustee’s Disclaimer. 83 Section 11.05. Notice of Defaults. 83 Section 11.06. Compensation and Indemnity. 83 Section 11.07. Replacement of the Trustee. 84 Section 11.08. Successor Trustee by Merger, Etc. 85 Section 11.09. Eligibility; Disqualification. 85 Article 12. Miscellaneous 85 Section 12.01. Notices. 85 Section 12.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 87 Section 12.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 87 Section 12.04. Rules by the Trustee, the Registrar and the Paying Agent. 87 Section 12.05. No Personal Liability of Directors, Officers, Employees and Shareholders. 88 Section 12.06. Governing Law; Waiver of Jury Trial. 88 Section 12.07. Submission to Jurisdiction. 88 Section 12.08. No Adverse Interpretation of Other Agreements. 88 Section 12.09. Successors. 89 Section 12.10. Force Majeure. 89 Section 12.11. U.S.A. PATRIOT Act. 89 Section 12.12. Calculations. 89 Section 12.13. Severability. 89 Section 12.14. Counterparts. 89 Section 12.15. Table of Contents, Headings, Etc. 90 Section 12.16. Withholding Taxes. 90 Section 12.17. Trust Indenture Act Controls. 90 Exhibits Exhibit A: Form of Note A-1 Exhibit B: Form of Global Note Legend B-1 INDENTURE, dated as of [closing date], among Aegerion Pharmaceuticals, Inc., a Delaware corporation, as issuer (the “Company”), [New Parent], a company incorporated in England and Wales (the “Parent”), Amryt Pharma plc, a company incorporated in England and Wales (“Old Parent”), the additional guarantors listed on the signature pages hereto, as guarantors (together with the Parent and Old Parent, the “Guarantors”), and [trustee’s legal name], as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 5.00% Convertible Senior Notes due [maturity year] (the “Notes”).

Settlement Upon Conversion. 45 Section 5.04. Reserve and Status of Common Stock Issued Upon Conversion. 49 Section 5.05. Adjustments to the Conversion Rate. 50 49 Section 5.06. Voluntary Adjustments. 60 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 61 60 Section 5.08. Exchange in Lieu of Conversion. 62 61 Section 5.09. Effect of Common Stock Change Event. 63 Section 5.10. Responsibility of Trustee. 65 62 Article 6. Successors 65 64 Section 6.01. When the Company May Merge, Etc. 65 64 Section 6.02. Successor Entity Substituted. 66 65 Section 6.03. Exclusion for Asset Transfers with Wholly Owned Subsidiaries. 66 65 Article 7. Defaults and Remedies 66 65 Section 7.01. Events of Default. 66 65 Section 7.02. Acceleration. 68 67 Section 7.03. Sole Remedy for a Failure to Report. 69 68 Section 7.04. Other Remedies. 70 69 Section 7.05. Waiver of Past Defaults. 70 69 Section 7.06. Control by Majority. 70 69 Section 7.07. Limitation on Suits. 71 69 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 71 70 Section 7.09. Collection Suit by Trustee. 71 70 Section 7.10. Trustee May File Proofs of Claim. 72 70 Section 7.11. Priorities. 72 71 Section 7.12. Undertaking for Costs. 73 71 Article 8. Amendments, Supplements and Waivers 73 72 Section 8.01. Without the Consent of Holders. 73 72 Section 8.02. With the Consent of Holders. 74 73 Section 8.03. Notice of Amendments, Supplements and Waivers. 75 74 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 75 74 Section 8.05. Notations and Exchanges. 76 75 Section 8.06. Trustee to Execute Supplemental Indentures. 7675 Article 9. Satisfaction and Discharge 75 Section 9.01. Termination of Company’s Obligations. 75 Section 9.02. Repayment to Company. 76 Section 9.03. Reinstatement. 76 Article 10. Trustee 76 Section 10.01. Duties of the Trustee. 76 Section 10.02. Rights of the Trustee. 78 Section 10.03. Individual Rights of the Trustee. 78 Section 10.04. Trustee’s Disclaimer. 79 Section 10.05. Notice of Defaults. 79 Section 10.06. Compensation and Indemnity. 79 Section 10.07. Replacement of the Trustee. 80 Section 10.08. Successor Trustee by Xxxxxx, Etc. 81 Section 10.09. Eligibility; Disqualification. 81 Article 11. Miscellaneous 82 Section 11.01. Notices. 82 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 84 Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 84 Section 11.04. Rules by the Trustee, the Registrar, the Paying Agent and the Conversion Agent. 84 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 84 Section 11.06. Governing Law; Waiver of Jury Trial. 85 Section 11.07. Submission to Jurisdiction. 85 Section 11.08. No Adverse Interpretation of Other Agreements. 85 Section 11.09. Successors. 85 Section 11.10. Force Majeure. 85 Section 11.11. U.S.A. PATRIOT Act. 86 Section 11.12. Calculations. 86 Section 11.13. Severability. 86 Section 11.14. Counterparts. 86 Section 11.15. Table of Contents, Headings, Etc. 86 Section 11.16. Withholding Taxes. 87 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1: Form of Restricted Note Legend B1-1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Legend B3-1 INDENTURE, dated as of October 11, 2023, between Rivian Automotive, Inc., a Delaware corporation, as issuer (the “Company”), and U.S. Bank Trust Company, National Association, as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 3.625% Green Convertible Senior Notes due 2030 (the “Notes”).

Settlement Upon Conversion. 45 Section 5.04. Reserve and Status of Common Stock Shares Issued Upon Conversion. 49 48 Section 5.05. Adjustments to the Conversion Rate. 50 49 Section 5.06. Voluntary Adjustments. 60 59 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 61 59 Section 5.08. Exchange in Lieu of Conversion. 62 61 Section 5.09. Effect of Common Stock Share Change Event. 63 Section 5.10. Responsibility of Trustee. 65 61 ​ ​ Article 6. Successors 65 63 ​ ​ ​ Section 6.01. When the Company May Merge, Etc. 65 63 Section 6.02. Successor Entity Corporation Substituted. 66 Section 6.03. Exclusion for Asset Transfers with Wholly Owned Subsidiaries. 66 64 ​ ​ Article 7. Defaults and Remedies 66 64 ​ ​ ​ Section 7.01. Events of Default. 66 64 Section 7.02. Acceleration. 68 66 Section 7.03. Sole Remedy for a Failure to Report. 69 67 Section 7.04. Other Remedies. 70 68 Section 7.05. Waiver of Past Defaults. 70 68 Section 7.06. Control by Majority. 70 68 Section 7.07. Limitation on Suits. 71 69 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 71 69 Section 7.09. Collection Suit by Trustee. 71 69 Section 7.10. Trustee May File Proofs of Claim. 72 70 Section 7.11. Priorities. 72 70 Section 7.12. Undertaking for Costs. 73 71 ​ ​ Article 8. Amendments, Supplements and Waivers 73 71 ​ ​ ​ Section 8.01. Without the Consent of Holders. 73 71 Section 8.02. With the Consent of Holders. 74 72 Section 8.03. Notice of Amendments, Supplements and Waivers. 75 73 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 75 73 Section 8.05. Notations and Exchanges. 76 74 Section 8.06. Trustee to Execute Supplemental Indentures. 7674 ​ ​ Article 9. Guarantees 74 ​ - ii - ​ ​ Section 9.01. Guarantees. 74 Section 9.02. Limitation on Guarantor Liability. 76 Section 9.03. Execution and Delivery of Guarantee. 76 Section 9.04. When the Guarantor May Merge, Etc. 76 Section 9.05. Application of Certain Provisions to the Guarantor. 77 ​ ​ Article 10. Satisfaction and Discharge 77 ​ ​ ​ Section 10.01. Termination of Company’s Obligations. 77 Section 10.02. Repayment to Company. 78 Section 10.03. Reinstatement. 78 ​ ​ Article 11. Trustee 79 ​ ​ ​ Section 11.01. Duties of the Trustee. 79 Section 11.02. Rights of the Trustee. 80 Section 11.03. Individual Rights of the Trustee. 81 Section 11.04. Trustee’s Disclaimer. 81 Section 11.05. Notice of Defaults. 81 Section 11.06. Compensation and Indemnity. 81 Section 11.07. Replacement of the Trustee. 82 Section 11.08. Successor Trustee by Merger, Etc. 83 Section 11.09. Eligibility; Disqualification. 83 ​ ​ Article 12. Miscellaneous 83 ​ ​ ​ Section 12.01. Notices. 83 Section 12.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 85 Section 12.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 86 Section 12.04. Rules by the Trustee, the Registrar, the Paying Agent and the Conversion Agent. 86

Settlement Upon Conversion. 45 44 Section 5.04. Reserve and Status of Common Stock Issued Upon Conversion. 49 48 Section 5.05. Adjustments to the Conversion Rate. 50 48 Section 5.06. Voluntary Adjustments. 60 59 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 61 59 Section 5.08. Exchange in Lieu of Conversion. 62 61 Section 5.09. Effect of Common Stock Change Event. 63 Section 5.10. Responsibility of Trustee. 65 61 Article 6. Successors 65 63 Section 6.01. When the Company May Merge, Etc. 65 63 Section 6.02. Successor Entity Substituted. 66 64 Section 6.03. Exclusion for Asset Transfers with Wholly Owned Subsidiaries. 66 64 Article 7. Defaults and Remedies 66 64 Section 7.01. Events of Default. 66 64 Section 7.02. Acceleration. 68 66 Section 7.03. Sole Remedy for a Failure to Report. 69 67 Section 7.04. Other Remedies. 70 68 Section 7.05. Waiver of Past Defaults. 70 68 Section 7.06. Control by Majority. 70 68 Section 7.07. Limitation on Suits. 71 68 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 71 69 Section 7.09. Collection Suit by Trustee. 71 69 Section 7.10. Trustee May File Proofs of Claim. 72 69 Section 7.11. Priorities. 72 70 Section 7.12. Undertaking for Costs. 73 70 Article 8. Amendments, Supplements and Waivers 73 71 Section 8.01. Without the Consent of Holders. 73 71 Section 8.02. With the Consent of Holders. 74 72 Section 8.03. Notice of Amendments, Supplements and Waivers. 75 73 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 75 73 Section 8.05. Notations and Exchanges. 76 74 Section 8.06. Trustee to Execute Supplemental Indentures. 7674 Article 9. Satisfaction and Discharge 74 Section 9.01. Termination of Company’s Obligations. 74 Section 9.02. Repayment to Company. 75 Section 9.03. Reinstatement. 75 Article 10. Trustee 75 Section 10.01. Duties of the Trustee. 75 Section 10.02. Rights of the Trustee. 76 Section 10.03. Individual Rights of the Trustee. 77 Section 10.04. Trustee’s Disclaimer. 78 Section 10.05. Notice of Defaults. 78 Section 10.06. Compensation and Indemnity. 78 Section 10.07. Replacement of the Trustee. 79 Section 10.08. Successor Trustee by Xxxxxx, Etc. 80 Section 10.09. Eligibility; Disqualification. 80 Article 11. Miscellaneous 81 Section 11.01. Notices. 81 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 83 Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 83 Section 11.04. Rules by the Trustee, the Registrar, the Paying Agent and the Conversion Agent. 83 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 83 Section 11.06. Governing Law; Waiver of Jury Trial. 84 Section 11.07. Submission to Jurisdiction. 84 Section 11.08. No Adverse Interpretation of Other Agreements. 84 Section 11.09. Successors. 84 Section 11.10. Force Majeure. 84 Section 11.11. U.S.A. PATRIOT Act. 85 Section 11.12. Calculations. 85 Section 11.13. Severability. 85 Section 11.14. Counterparts. 85 Section 11.15. Table of Contents, Headings, Etc. 85 Section 11.16. Withholding Taxes. 86 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1: Form of Restricted Note Legend B1-1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Affiliate Resale Legend B3-1 iii INDENTURE, dated as of March 20, 2023, between Freshpet, Inc., a Delaware corporation, as issuer (the “Company”), and U.S. Bank Trust Company, National Association, as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 3.00% Convertible Senior Notes due 2028 (the “Notes”).

Settlement Upon Conversion. 45 ‌ 46 Section 5.04. Reserve and Status of Common Stock Issued Upon upon Conversion. ‌ 49 Section 5.05. Adjustments to the Conversion Rate. 50 ‌ 49 Section 5.06. Voluntary Adjustments. 60 ‌ 59 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 61 ‌ 59 Section 5.08. Exchange in Lieu of Conversion. 62 ‌ 61 Section 5.09. Effect of Common Stock Change Event. ‌ 61 Article 6 Successors ‌ 63 Section 5.10. Responsibility of Trustee. 65 Article 6. Successors 65 Section 6.01. When the Company May Merge, Etc. 65 ‌ 63 Section 6.02. Successor Entity Corporation Substituted. 66 Section 6.03. Exclusion for Asset Transfers with Wholly Owned Subsidiaries. 66 ‌ 64 Article 7. 7 Defaults and Remedies 66 ‌ 64 Section 7.01. Events of Default. 66 ‌ 64 Section 7.02. Acceleration. 68 ‌ 66 Section 7.03. Sole Remedy for a Failure to Report. 69 ‌ 67 Section 7.04. Other Remedies. 70 ‌ 68 Section 7.05. Waiver of Past Defaults. 70 ‌ 68 Section 7.06. Control by Majority. 70 ‌ 68 Section 7.07. Limitation on Suits. 71 ‌ 69 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 71 ‌ 69 Section 7.09. Collection Suit by Trustee. 71 ‌ 69 Section 7.10. Trustee May File Proofs of Claim. 72 ‌ 70 Section 7.11. Priorities. 72 ‌ 70 Section 7.12. Undertaking for Costs. 73 ‌ 71 Article 8. 8 Amendments, Supplements and Waivers 73 ‌ 71 Section 8.01. Without the Consent of Holders. 73 ‌ 71 Section 8.02. With the Consent of Holders. 74 ‌ 72 Section 8.03. Notice of Amendments, Supplements and Waivers. 75 ‌ 73 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 75 ‌ 73 Section 8.05. Notations and Exchanges. 76 ‌ 74 Section 8.06. Trustee to Execute Supplemental Indentures. 76‌ 74 Article 9 Satisfaction and Discharge ‌ 74 Section 9.01. Termination of Company’s Obligations. ‌ 74 Section 9.02. Repayment to Company. ‌ 75 Section 9.03. Reinstatement. ‌ 75 - ii - ‌ ​ ​ ​ Article 10 Trustee ‌ 75 Section 10.01. Duties of the Trustee. ‌ 75 Section 10.02. Rights of the Trustee. ‌ 76 Section 10.03. Individual Rights of the Trustee. ‌ 78 Section 10.04. Trustee’s Disclaimer. ‌ 78 Section 10.05. Notice of Defaults. ‌ 78 Section 10.06. Compensation and Indemnity. ‌ 78 Section 10.07. Replacement of the Trustee. ‌ 79 Section 10.08. Successor Trustee by Xxxxxx, Etc. ‌ 80 Section 10.09. Eligibility; Disqualification. ‌ 80 Article 11 Miscellaneous ‌ 80 Section 11.01. Notices. ‌ 80 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. ‌ 82

Settlement Upon Conversion. 45 40 Section 5.04. Reserve and Status of Common Stock Issued Upon Conversion. 49 41 Section 5.05. Adjustments to the Conversion Rate. 50 42 Section 5.06. Voluntary Adjustments. 60 52 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 61 53 Section 5.08. Exchange in Lieu of Conversion. 62 54 Section 5.09. Effect of Common Stock Change Event. 63 Section 5.10. Responsibility of Trustee. 65 54 Article 6. Successors 65 56 Section 6.01. When the Company May Merge, Etc. 65 56 Section 6.02. Successor Entity Corporation Substituted. 66 Section 6.03. Exclusion for Asset Transfers with Wholly Owned Subsidiaries. 66 57 Article 7. Defaults and Remedies 66 57 Section 7.01. Events of Default. 66 57 Section 7.02. Acceleration. 68 59 Section 7.03. Sole Remedy for a Failure to Report. 69 59 Section 7.04. Other Remedies. 70 60 Section 7.05. Waiver of Past Defaults. 70 61 Section 7.06. Control by Majority. 70 61 Section 7.07. Limitation on Suits. 71 61 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 71 62 Section 7.09. Collection Suit by Trustee. 71 62 Section 7.10. Trustee May File Proofs of Claim. 72 62 Section 7.11. Priorities. 72 63 Section 7.12. Undertaking for Costs. 73 63 Article 8. Amendments, Supplements and Waivers 73 64 Section 8.01. Without the Consent of Holders. 73 64 Section 8.02. With the Consent of Holders. 74 64 Section 8.03. Notice of Amendments, Supplements and Waivers. 75 65 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 75 66 Section 8.05. Notations and Exchanges. 76 66 Section 8.06. Trustee to Execute Supplemental Indentures. 7667 Article 9. Satisfaction and Discharge; Defeasance of Certain Covenants 67 Table of Contents Section 9.01. Termination of Company’s Obligations. 67 Section 9.02. Repayment to Company. 68 Section 9.03. Reinstatement. 68 Section 9.04. Defeasance of Restrictive Covenants. 68 Article 10. Trustee 69 Section 10.01. Duties of the Trustee. 69 Section 10.02. Rights of the Trustee. 70 Section 10.03. Individual Rights of the Trustee. 71 Section 10.04. Trustee’s Disclaimer. 72 Section 10.05. Notice of Defaults. 72 Section 10.06. Compensation and Indemnity. 72 Section 10.07. Replacement of the Trustee. 73 Section 10.08. Successor Trustee by Merger, Etc. 74 Section 10.09. Eligibility; Disqualification. 74 Article 11. Miscellaneous 74 Section 11.01. Notices. 74 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 76 Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 76 Section 11.04. Rules by the Trustee, the Registrar and the Paying Agent. 76 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 77 Section 11.06. Governing Law; Waiver of Jury Trial. 77 Section 11.07. Submission to Jurisdiction. 77 Section 11.08. No Adverse Interpretation of Other Agreements. 77 Section 11.09. Successors. 77 Section 11.10. Force Majeure. 78 Section 11.11. U.S.A. PATRIOT Act. 78 Section 11.12. Calculations. 78 Section 11.13. Severability. 78 Section 11.14. Counterparts. 78 Section 11.15. Table of Contents, Headings, Etc. 78 Section 11.16. Withholding Taxes. 79 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1A: Form of Restricted Note Legend (Non-Affiliate Note) B1A-1 Exhibit B-1B: Form of Restricted Note Legend (Affiliate Note) B1B-1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Legend B3-1 Table of Contents INDENTURE, dated as of December 7, 2020, between Progenity, Inc., a Delaware corporation, as issuer (the “Company”), and The Bank of New York Mellon Trust Company, N.A., as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 7.25% Convertible Senior Notes due 2025 (the “Notes”).

Settlement Upon Conversion. 45 Section 5.04. Reserve and Status of Common Stock Issued Upon Conversion. 49 48 Section 5.05. Adjustments to the Conversion Rate. 50 49 Section 5.06. Voluntary Adjustments. 60 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 61 Section 5.08. Exchange in Lieu of Conversion. 62 Section 5.09. Effect of Common Stock Change Event. 63 Section 5.10. Responsibility of Trustee. 65 Article 6. Successors 65 Section 6.01. When the Company May Merge, Etc. 65 Section 6.02. Successor Entity Corporation Substituted. 66 Section 6.03. Exclusion for Asset Transfers with Wholly Owned Subsidiaries. 66 65 Article 7. Defaults and Remedies 66 Section 7.01. Events of Default. 66 Section 7.02. Acceleration. 68 Section 7.03. Sole Remedy for a Failure to Report. 69 68 Section 7.04. Other Remedies. 70 69 Section 7.05. Waiver of Past Defaults. 70 Section 7.06. Control by Majority. 70 Section 7.07. Limitation on Suits. 71 70 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 71 Section 7.09. Collection Suit by Trustee. 71 Section 7.10. Trustee May File Proofs of Claim. 72 71 Section 7.11. Priorities. 72 Section 7.12. Undertaking for Costs. 73 72 Article 8. Amendments, Supplements and Waivers 73 Section 8.01. Without the Consent of Holders. 73 Section 8.02. With the Consent of Holders. 74 Section 8.03. Notice of Amendments, Supplements and Waivers. 75 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 75 Section 8.05. Notations and Exchanges. 76 Section 8.06. Trustee to Execute Supplemental Indentures. 7676 Article 9. Satisfaction and Discharge 76 Section 9.01. Termination of Company’s Obligations. 76 Section 9.02. Repayment to Company. 77 Section 9.03. Reinstatement. 77 Article 10. Trustee 77 Section 10.01. Duties of the Trustee. 77 Section 10.02. Rights of the Trustee. 79 Section 10.03. Individual Rights of the Trustee. 80 Section 10.04. Trustee’s Disclaimer. 80 Section 10.05. Notice of Defaults. 81 Section 10.06. Compensation and Indemnity. 81 Section 10.07. Replacement of the Trustee. 82 Section 10.08. Successor Trustee by Merger, Etc. 83 Section 10.09. Eligibility; Disqualification. 83 Article 11. Miscellaneous 83 Section 11.01. Notices. 83 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 85 Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 86 Section 11.04. Rules by the Trustee, the Registrar, the Paying Agent and Conversion Agent. 86

Settlement Upon Conversion. 45 39 Section 5.04. Reserve and Status of Common Stock Issued Upon upon Conversion. 49 42 Section 5.05. Adjustments to the Conversion Rate. 50 43 Section 5.06. Voluntary Adjustments. 60 54 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 61 54 Section 5.08. Exchange in Lieu of Conversion. 62 55 Section 5.09. Effect of Common Stock Change Event. 63 Section 5.10. Responsibility of Trustee. 65 56 Article 6. Successors 65 57 Section 6.01. When the Company May Merge, Etc. 65 57 Section 6.02. Successor Entity Corporation Substituted. 66 Section 6.03. Exclusion for Asset Transfers with Wholly Owned Subsidiaries. 66 58 Article 7. Defaults and Remedies 66 58 Section 7.01. Events of Default. 66 58 Section 7.02. Acceleration. 68 60 Section 7.03. Sole Remedy for a Failure to Report. 69 61 Section 7.04. Other Remedies. 70 62 Section 7.05. Waiver of Past Defaults. 70 62 Section 7.06. Control by Majority. 70 62 Section 7.07. Limitation on Suits. 71 63 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 71 63 Section 7.09. Collection Suit by Trustee. 71 63 Section 7.10. Trustee May File Proofs of Claim. 72 64 Section 7.11. Priorities. 72 64 Section 7.12. Undertaking for Costs. 73 65 Article 8. Amendments, Supplements and Waivers 73 65 Section 8.01. Without the Consent of Holders. 73 65 Section 8.02. With the Consent of Holders. 74 66 Section 8.03. Notice of Amendments, Supplements and Waivers. 75 67 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 75 67 Section 8.05. Notations and Exchanges. 76 68 Section 8.06. Trustee to Execute Supplemental Indentures. 7668

Settlement Upon Conversion. 45 39 Section 5.04. Reserve and Status of Common Stock Issued Upon Conversion. 49 42 Section 5.05. Adjustments to the Conversion Rate. 50 43 Section 5.06. Voluntary Adjustments. 60 53 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 61 53 Section 5.08. Exchange in Lieu of Conversion. 62 54 Section 5.09. Effect of Common Stock Change Event. 63 Section 5.10. Responsibility of Trustee. 65 55 Article 6. Successors 65 57 Section 6.01. When the Company May Merge, Etc. 65 57 Section 6.02. Successor Entity Corporation Substituted. 66 57 Section 6.03. Exclusion for Certain Asset Transfers with Wholly Owned SubsidiariesTransfers. 66 57 Article 7. Defaults and Remedies 66 57 Section 7.01. Events of Default. 66 57 Section 7.02. Acceleration. 68 59 Section 7.03. Sole Remedy for a Failure to Report. 69 60 Section 7.04. Other Remedies. 70 61 Section 7.05. Waiver of Past Defaults. 70 61 Section 7.06. Control by Majority. 70 61 Section 7.07. Limitation on Suits. 71 61 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 71 62 Section 7.09. Collection Suit by Trustee. 71 62 Section 7.10. Trustee May File Proofs of Claim. 72 62 Section 7.11. Priorities. 72 63 Section 7.12. Undertaking for Costs. 73 63 Article 8. Amendments, Supplements and Waivers 73 63 Section 8.01. Without the Consent of Holders. 73 63 Section 8.02. With the Consent of Holders. 74 64 Section 8.03. Notice of Amendments, Supplements and Waivers. 75 65 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 75 65 Section 8.05. Notations and Exchanges. 76 66 Section 8.06. Trustee to Execute Supplemental Indentures. 7666 Article 9. Satisfaction and Discharge 66 Section 9.01. Termination of Company’s Obligations. 66 Section 9.02. Repayment to Company. 67 Section 9.03. Reinstatement. 67 Article 10. Trustee 67 Section 10.01. Duties of the Trustee. 67 Section 10.02. Rights of the Trustee. 69 Section 10.03. Individual Rights of the Trustee. 69 Section 10.04. Trustee’s Disclaimer. 69 Section 10.05. Notice of Defaults. 70 Section 10.06. Compensation and Indemnity. 70 Section 10.07. Replacement of the Trustee. 71 Section 10.08. Successor Trustee by Merger, Etc. 72 Section 10.09. Eligibility; Disqualification. 72 Article 11. Miscellaneous 72 Section 11.01. Notices. 72 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 73 Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 74 Section 11.04. Rules by the Trustee, the Registrar, the Paying Agent and Conversion Agent. 74 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 74 Section 11.06. Governing Law; Waiver of Jury Trial. 74 Section 11.07. Submission to Jurisdiction. 74 Section 11.08. No Adverse Interpretation of Other Agreements. 75 Section 11.09. Successors. 75 Section 11.10. Force Majeure. 75 Section 11.11. U.S.A. PATRIOT Act. 75 Section 11.12. Calculations. 75 Section 11.13. Severability. 76 Section 11.14. Counterparts. 76 Section 11.15. Table of Contents, Headings, Etc. 76 Section 11.16. Withholding Taxes. 76 Exhibits Exhibit A: Form of Note X-0 Xxxxxxx X-0: Form of Restricted Note Legend B1-1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Legend B3-1 INDENTURE, dated as of January 19, 2022, between Virgin Galactic Holdings, Inc., a Delaware corporation, as issuer (the “Company”), and U.S. Bank National Association, as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 2.50% Convertible Senior Notes due 2027.