GABA Clause Samples

GABA. GABA is the primary inhibiting neurotransmitter in the brain and is synthesised from glutamate by the enzyme glutamic acid decarboxylase. GABA binds to both GABAA (ionotropic) and GABAB (metabotropic) receptors. The ion channel in the GABAa receptor is permeable to chloride and counteracts the inhibitory effect of depolarising influences such as glutamate (▇▇▇▇▇▇ et al., 2000). Numerous AEDs activate ionotropic GABAa receptors which include the benzodiazepines diazepam, clobozam and clonazepam. Other GABA medications modulate responses at the receptor such as topiramate. GABAb receptors can also be activated by G-coupled protein receptors via indirect activation of potassium channels, (▇▇▇▇▇▇▇ et al., 2002).