Common use of Figure Clause in Contracts

Figure. Three-dimensional mesh of the percentage of maximum theoretical window for hypothetic inverse agonists with continuous intrinsic efficacy (a) values between 0.001 to 1 on hypothetic receptors with continuous ratios of active versus inactive receptors (L values) between 0.001 to 1000. In figure 8B, concentration-response curves are shown for receptors with L values of 0.01, 1, 10 and 100 for a strong inverse agonist with an a value of 0.001 (closed circles in figure 8A). Similarly, in figure 8C, concentration-response curves are shown for a weak inverse agonist with an a value of 0.1 (open circles in figure 8A). (z-axis) and the percentage of the maximum theoretical window (y-axis) can be visualized in a 3-D mesh (see Figure 8A). A series of bell-shaped curves represent the percentage of the maximum theoretical window that can be achieved when log a and log L are varied. This mesh shows that for a ligand with an a value between 0.001 and 1 an optimal theoretical window can be achieved for receptors with a log L value close to 1. Within the framework of the two-state receptor model, the theoretical window ( q0-qœ ) is calculated as L/(L+1)- aL/(1+aL) . An optimal theoretical window will be obtained when the relationship between the level of constitutive activity (L) of a receptor and the a value of the ligand obeys the following equation L = 1 equation 5 The 3-D mesh is composed of a series of bell-shaped curve according to the different intrinsic efficacies of a ligand. The maximum is achieved when L equals the reciprocal square root of

Figure. Three-dimensional mesh of the percentage of maximum theoretical window for hypothetic inverse agonists with continuous intrinsic efficacy (aα) values between 0.001 to 1 on hypothetic receptors with continuous ratios of active versus inactive receptors (L values) between 0.001 to 1000. In figure 8B, concentration-response curves are shown for receptors with L values of 0.01, 1, 10 and 100 for a strong inverse agonist with an a value of 0.001 (closed circles in figure 8A). Similarly, in figure 8C, concentration-response curves are shown for a weak inverse agonist with an a value of 0.1 (open circles in figure 8A). (z-axis) and the percentage of the maximum theoretical window (y-axis) can be visualized in a 3-D mesh (see Figure 8A). A series of bell-shaped curves represent the percentage of the maximum theoretical window that can be achieved when log a α and log L are varied. This mesh shows that for a ligand with an a α value between 0.001 and 1 an optimal theoretical window can be achieved for receptors with a log L value close to 1. Within the framework of the two-state receptor model, the theoretical window ( q0ρ0-qœ ρ∞ ) is calculated as L/(L+1)- aL/(1+aL) . An optimal theoretical window will be obtained when the relationship between the level of constitutive activity (L) of a receptor and the a α value of the ligand obeys the following equation L = 1 equation 5 The 3-D mesh is composed of a series of bell-shaped curve according to the different intrinsic efficacies of a ligand. The maximum is achieved when L equals the reciprocal square root of