Common use of Expansion Clause in Contracts

Expansion. Tenant has exercised Tenant's Refusal Right with respect to the Refusal Space, consisting of 9,040 rentable square feet of space located adjacent to the Original Premises and more particularly identified on Exhibit A attached hereto and incorporated herein by this reference ("Additional Space"). The Additional Space, together with the Original Premises, aggregating 33,025 rentable square feet, is leased by Tenant on the following terms and conditions: (a) The Additional Space is leased in its "as is," "where is," existing condition. Landlord shall have no obligation to make any improvements whatsoever in the Additional Space. (b) Notwithstanding the foregoing, Landlord shall give Tenant a tenant finish allowance for the Additional Space in the amount of $22.00 per rentable square foot of the Additional Space (i.e. $198,880.00) ("Additional Space Allowance"). The Additional Space Allowance shall be paid by Landlord to Tenant on the same terms and conditions as provided in the Lease with respect to payment by Landlord of the Tenant Finish allowance. (c) On December 1, 1999, Tenant shall commence paying Base Rent on the Additional Space as hereinafter set forth in an amount of $13.80 per rentable square foot of the Additional Space for the first 36 months and $15.04 per rentable square foot of the Additional Space for the balance of the Primary Lease Term, as hereinafter defined.

Expansion. Tenant Upon receipt of written notice from Landlord that the lease for approximately 21,550 rentable square feet to BG Medicine, Inc. (the “BG Lease”) has exercised terminated and that the BG Expansion Premises are being delivered to Tenant's Refusal Right , the Premises shall automatically expand in accordance with respect this Section 2.1.2 to the Refusal Space, consisting of 9,040 include an additional 21,550 rentable square feet of space located adjacent to in the Original Building (the “BG Expansion Premises”), which BG Expansion Premises and is more particularly identified shown on Exhibit A the plan attached hereto and incorporated herein by as Exhibit A-1. Following the expansion described in this reference ("Additional Space")Section 2.1.2, the Premises will include all common areas of the Building. The Additional Space, together with the Original Premises, aggregating 33,025 rentable square feet, is leased by Tenant on the following terms and conditions: (a) The Additional Space is leased in its "as is," "where is," existing condition. Landlord shall have no obligation to make any improvements whatsoever in the Additional Space. (b) Notwithstanding the foregoing, Landlord shall give Tenant a tenant finish allowance for the Additional Space in the amount of $22.00 per rentable square foot lease of the Additional Space (i.e. $198,880.00) ("Additional Space Allowance"). The Additional Space Allowance BG Expansion Premises shall be paid by Landlord to Tenant on the same terms and conditions as provided in the Lease with respect to payment by Landlord of the Tenant Finish allowance. (c) On December 1, 1999, Tenant shall commence paying Base Rent on the Additional Space as hereinafter that are set forth in this Lease for the Premises, including without limitation, Section 2.4.1 below, except that the Rent Commencement Date for the BG Expansion Premises shall be ninety (90) days after the date on which the BG Expansion Premises are delivered to Tenant in accordance herewith (the “BG Delivery Date”), the Improvement Allowance for the BG Expansion Premises shall be $495,650 and the Space Planning Allowance for the BG Expansion Premises shall be $48,487.50. The provisions of this Section 2.1.2 shall be self-operative, but at either party’s request, Landlord and Tenant shall enter into an amount of $13.80 per rentable square foot amendment to this Lease to reflect the expansion of the Additional Space for Premises to include the first 36 months and $15.04 per rentable square foot BG Expansion Premises. The BG Expansion Premises shall be delivered to Tenant in “broom clean” condition, but including all biotechnology trade fixtures that are affixed to the BG Expansion Premises as of the Additional Space for date hereof, including any benches, cabinets and racks, and free of all tenants and occupants, and such delivery shall be subject to the balance provisions of Section 2.4(d) below. The term of the Primary BG Lease Termis scheduled to expire on June 30, as hereinafter defined2008 (and the tenant thereunder is entitled to an extension term of one (1) additional year). Notwithstanding the provisions of this Section 2.1.2, the BG Delivery Date shall not occur prior to June 30, 2009 and no later than July 1, 2010 (the “BG Outside Delivery Date”), it being agreed that Tenant may terminate its rights to the BG Expansion Premises if the BG Delivery date occurs later than the Outside BG Delivery Date.

Expansion. Tenant has exercised Tenant's Refusal Right with respect As used herein, “Expansion Premises” shall mean the increment of space commonly known as Suite D in the building located at ▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇ ▇▇▇▇▇▇ consisting of approximately 2,850 square feet more particularly shown on the attached Exhibit #1. The Expansion Premises shall be added to the Refusal SpaceExisting Premises on July 1, consisting 2013 and shall remain a portion of 9,040 rentable the “Premises” (as defined below) throughout the Expansion Term (as defined below). Landlord estimates that possession of the Expansion Premises will be tendered to Tenant on July 1, 2013 (the “Estimated Delivery Date”); provided, however, that if Landlord is unable to tender possession of the Expansion Premises to Tenant by the Estimated Delivery Date, then: (a) the validity of this Amendment shall not be affected or impaired thereby; (b) Landlord shall not be in default hereunder or be liable for damages therefor; and (c) Tenant shall accept possession of the Expansion Premises on the date when Landlord tenders possession thereof to Tenant. As of July 1, 2013, the definition of “Premises” in the Basic Lease Information of the Lease shall be modified to provide that the “Premises” consists of 9,658 square feet of space located adjacent to (the Original combined Existing Premises and more particularly identified on Exhibit A attached hereto and incorporated herein by this reference ("Additional Space"the Expansion Premises shall hereafter be referred to as the “Premises”). The Additional SpaceExpansion Premises shall remain a portion of the “Premises” throughout the Term of the Lease. As used herein, together with the Original Premises“Expansion Term” shall mean the period starting on July 1, aggregating 33,025 rentable square feet2013 and ending on August 31, is leased by 2015. Tenant on shall accept the following terms and conditions: (a) The Additional Space is leased Expansion Premises in its "their “as is," "where is," existing condition. ” state and condition and Landlord shall have no obligation to make or pay for any improvements whatsoever or renovations in or to the Additional SpaceExpansion Premises or to otherwise prepare the Expansion Premises for Tenant’s occupancy. (b) Notwithstanding the foregoing, Landlord shall give Tenant a tenant finish allowance for the Additional Space in the amount of $22.00 per rentable square foot of the Additional Space (i.e. $198,880.00) ("Additional Space Allowance"). The Additional Space Allowance shall be paid by Landlord to Tenant on the same terms and conditions as provided in the Lease with respect to payment by Landlord of the Tenant Finish allowance. (c) On December 1, 1999, Tenant shall commence paying Base Rent on the Additional Space as hereinafter set forth in an amount of $13.80 per rentable square foot of the Additional Space for the first 36 months and $15.04 per rentable square foot of the Additional Space for the balance of the Primary Lease Term, as hereinafter defined.

Expansion. Effective as of the Expansion Effective Date (defined below), the Premises, as defined in the Lease, is increased from 25,805 rentable square feet on the 14th floor to 36,385 rentable square feet on the 14th and 17th floors by the addition of the Expansion Space, and from and after the Expansion Effective Date, the Original Premises and the Expansion Space, collectively, shall be deemed the Premises, as defined in the Lease. The Term for the Expansion Space shall commence on the Expansion Effective Date and end on the Termination Date (as defined in the Lease). The Expansion Space is subject to all the terms and conditions of the Lease (including all restrictions set forth in Section 5 of the Lease, provided that in no event shall any portion of the Landlord Work, as hereinafter defined, performed by Landlord in the Expansion Space prior the delivery of same to Tenant has exercised Tenant's Refusal Right be deemed to create any Tenant Triggered Compliance obligations), except as expressly modified herein and except that Tenant shall not be entitled to receive any allowances, abatements or other financial concessions granted with respect to the Refusal Space, consisting of 9,040 rentable square feet of space located adjacent to the Original Premises and more particularly identified on Exhibit A attached hereto and incorporated unless such concessions are expressly provided for herein by this reference ("Additional Space"). The Additional Space, together with the Original Premises, aggregating 33,025 rentable square feet, is leased by Tenant on the following terms and conditions: (a) The Additional Space is leased in its "as is," "where is," existing condition. Landlord shall have no obligation to make any improvements whatsoever in the Additional Space. (b) Notwithstanding the foregoing, Landlord shall give Tenant a tenant finish allowance for the Additional Space in the amount of $22.00 per rentable square foot of the Additional Space (i.e. $198,880.00) ("Additional Space Allowance"). The Additional Space Allowance shall be paid by Landlord to Tenant on the same terms and conditions as provided in the Lease with respect to payment by the Expansion Space. Landlord and Tenant stipulate and agree that the rentable square footage of the Tenant Finish allowance. (c) On December 1Expansion Space is correct and shall not be remeasured, 1999, unless there is an actual physical change in the Expansion Space. Tenant shall commence paying Base deliver to Landlord the first month’s estimated gross Rent on the Additional Space as hereinafter set forth in an amount of $13.80 per rentable square foot obligation concurrently with its delivery of the Additional Space for the first 36 months and $15.04 per rentable square foot Tenant-executed copy of the Additional Space for the balance of the Primary Lease Term, as hereinafter definedthis Amendment.

Expansion. During the initial thirty-six (36) months of the Term, Tenant has exercised Tenant's Refusal Right with respect shall have the right to request additional space on the second and fourth floor within the Office Unit from Landlord to the Refusal Space, consisting of 9,040 rentable square feet of extent space located adjacent to the Original Premises and more particularly identified on Exhibit A attached hereto and incorporated herein by this reference ("Additional Space")is available. The Additional Space, together with the Original Premises, aggregating 33,025 rentable square feet, is leased by Tenant on the following terms and conditions: (a) The Additional Space is leased in its "as is," "where is," existing condition. Landlord shall have no obligation to make any improvements whatsoever in the Additional Space. (b) Notwithstanding the foregoing, Landlord shall give Tenant a tenant finish allowance for the Additional Space in the amount of $22.00 per rentable square foot of the Additional Space (i.e. $198,880.00) ("Additional Space Allowance"). The Additional Space Allowance shall be paid by Landlord deemed to Tenant agree to lease any such expansion space on the same terms and conditions as this Lease, except that (i) the definition of Premises shall be amended to include the expansion space, (iii) the Fixed Basic Rent payable for the expansion space shall be equal to the per square foot amount of Fixed Basic Rent then payable for the Premises, which shall be subject to adjustment pursuant to Section 1.N, (iv) Tenant’s Proportionate Share of Operating Expenses and Increases in Real Estate Taxes shall be proportionately increased based upon the addition of the expansion space to the Premises, (v) Tenant shall accept the expansion space in its “as is” condition, (vi) Landlord shall provide the same per square foot Tl Allowance as was provided in for the Premises as a tenant improvement allowance for the expansion space but ratably reduced based on the length of the remaining term after the expansion space is delivered to Tenant for the construction of tenant improvements within the expansion space as approved by Landlord, (vii) Landlord shall provide the same number of parking spaces per square foot of the expansions space that was provided for the Premises, (viii) the term of the Lease shall commence with respect to payment by Landlord of the Tenant Finish allowance. (c) On December 1, 1999, expansion space and Tenant shall commence paying Base Fixed Basic Rent and Additional Rent on the Additional Space date that is not greater than six (6) months after the delivery of Tenant’s request to expand, and (ix) the Termination Fee (as hereinafter set forth defined in Section 29) shall be increased by an amount of $13.80 per rentable square foot equal to 50% of the Additional Space Fixed Basic Rent payable for such expansion space for the first 36 months ninth, tenth and $15.04 per rentable square foot eleventh years of the Additional Space for the balance of the Primary Lease Term, as hereinafter defined.

Expansion. (a) Point Richmond R&D Associates, a California limited partnership (“PRA I”), as landlord, and Tenant, as tenant, are parties to that certain Lease dated as of February 22, 2006 (as amended, the “PRI Lease”), pursuant to which Tenant has exercised Tenant's Refusal Right with respect leases from PRA I, an affiliate of Landlord, the premises commonly known as Suites 110 and 130 (the “PRI Premises”) on the ground floor of the building located at ▇▇▇▇ ▇▇▇▇ ▇▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇, ▇▇▇▇▇▇▇▇, ▇▇▇▇▇▇▇▇▇▇. Pursuant to the Refusal SpacePRI Lease, Tenant holds an option to expand (the “PRI Expansion Option”) into space consisting of 9,040 at least 5,000 rentable square feet of space located adjacent to area more than the Original aggregate of the Rentable Area of the Premises and more particularly identified on Exhibit A attached hereto and incorporated herein by this reference the rentable area of the PRI Premises ("Additional Space"the “Aggregate Premises”). The Additional Space, together with the Original Premises, aggregating 33,025 rentable square feet, is leased by Tenant on the following terms and conditions: (a) The Additional Space is leased in its "as is," "where is," existing condition. Landlord shall have no obligation to make any improvements whatsoever in the Additional Space. (b) Notwithstanding the foregoing, Landlord shall give If PRA I (or its Affiliate) and Tenant a tenant finish allowance have not agreed upon suitable space for the Additional Space Tenant (in the amount of $22.00 per rentable square foot Tenant’s sole opinion) within six (6) months following Tenant’s exercise of the Additional Space PRI Expansion Option, Tenant shall have the right to terminate this Lease by providing Landlord one hundred eighty (i.e. $198,880.00180) days prior notice specifying the unequivocal termination of this Lease, and provided further that Tenant provide such termination notice within thirty ("Additional Space Allowance"). The Additional Space Allowance shall be paid by Landlord to Tenant on the same terms and conditions as provided in the Lease with respect to payment by Landlord 30) days of the Tenant Finish allowanceexpiration of such six-month period. (c) On December 1If Tenant properly exercises its PRI Expansion Right, 1999and PRA I (or its Affiliate) and Tenant are able to agree on a space suitable for Tenant in accordance with the PRI Lease (the “Expansion Space”), as evidenced by the execution and delivery of the Expansion Amendment (as defined in the PRI Lease), Tenant shall commence paying Base Rent on have the Additional Space right to terminate this Lease as hereinafter set forth in an amount of $13.80 per rentable square foot of the Additional Space commencement date of the term for the first 36 months and $15.04 per rentable square foot Expansion Space by delivering written notice to Landlord within thirty (30) days following the date of the Additional Space for Expansion Amendment (as defined in the balance of the Primary PRI Lease). If Tenant fails to timely deliver such termination notice, Tenant shall be deemed to have elected to continue this Lease, and this Lease Term, as hereinafter definedwill remain in full force and effect.

Expansion. Landlord hereby leases to Tenant has exercised Tenant's Refusal Right with respect to the Refusal Space, consisting of 9,040 and Tenant hereby rents from Landlord an additional 15,078 rentable square feet of space located adjacent to the Original Premises and more particularly commonly known as Suite 200, as identified on Exhibit A attached hereto and incorporated herein by this reference ("Additional Space"). The Additional Space, together with the Original Premises, aggregating 33,025 rentable square feetaggregate 24,118, and is hereinafter referred to collectively as the "Premises." The Additional Space is leased by Tenant on the following terms and conditions: (a) A. The Additional Space is leased shall be completed in its "accordance with the terms of the Work Letter attached as is," "where is," existing condition. Landlord shall have no obligation Exhibit D to make any improvements whatsoever in the Original Lease, except that the Submission Date with respect to Tenant's delivery of space plans for the Additional Space. (b) Notwithstanding Space shall be October 1, 1999 and the foregoingPremises shall be Ready for Occupancy on or before January 1, 2000. Landlord shall give Tenant a tenant finish allowance for the Additional Space in the amount of $22.00 per rentable square foot of the Additional Space (i.e. $198,880.00331,716.00) ("Additional Space Allowance"). The Additional Space Allowance shall be paid by Landlord to Tenant on the same terms and conditions as provided in the Lease with respect to payment by Landlord of the Tenant Finish allowanceAllowance. (c) B. On December January 1, 19992000, Tenant shall commence paying Base Rent and Additional Rent on the Additional Space as hereinafter set forth forth. C. Simultaneously with execution of this Amendment, Tenant shall increase the Security Deposit by depositing with Landlord an additional Seventeen Thousand Three Hundred Thirty-Nine and 70/100 Dollars ($17,339.70) to be held by Landlord in an accordance with Section 4 of the Original Lease. The aggregate amount of the Security Deposit to be held by Landlord shall be $13.80 per rentable square foot 28,108.70. D. Tenant's Pro Rata Share is equal to 24.63%. E. Except as modified by this Amendment, all other terms and provisions of the Original Lease shall apply to Tenant's lease of the Additional Space for and all references in the first 36 months and $15.04 per rentable square foot of Lease to the "Premises" shall include the Additional Space for the balance of the Primary Lease Term, as hereinafter definedSpace.

Expansion. 24.1 Landlord agrees that Tenant has exercised Tenant's Refusal Right with respect shall have the right, at any time and from time to time during the Lease Term, to lease additional space in the Building which is contiguous to the Refusal Space, consisting of 9,040 rentable square feet of space located adjacent to Premises (the Original Premises and more particularly identified on Exhibit A attached hereto and incorporated herein by this reference ("Additional Space"). The Additional Space) as it becomes available following the vacation of such leased space by the then current tenant of such space, together with the Original Premises, aggregating 33,025 rentable square feet, is leased by Tenant on subject to the following terms and conditions: (a) The Additional Space is leased in its "as is," "where is," existing condition. Landlord shall have no obligation to make any improvements whatsoever in notify Tenant of the availability of the Additional Space. (b) Notwithstanding the foregoing, Landlord shall give Tenant a tenant finish allowance for The annual base rent and additional rent with respect to the Additional Space shall be the same amount per square foot and shall be adjusted at the same time and in the amount of $22.00 per rentable square foot of same manner as the Additional Space (i.e. $198,880.00) ("Additional Space Allowance"). The Additional Space Allowance shall be paid by Landlord to Tenant on the same terms adjusted annual base rent and conditions as provided additional rent then in the Lease effect with respect to payment by Landlord of the Tenant Finish allowanceoriginal Premises. (c) On December 1, 1999For a period of ten (10) days after receipt of any such notice from Landlord, Tenant shall commence paying Base Rent on have the right to lease the Additional Space as hereinafter from Landlord upon the terms and conditions set forth in this Lease (but without any obligation on the part of Landlord to construct, alter, renovate, repaint, recarpet or provide any construction allowance for tenant improvements in the Premises) commencing on the date the Additional Space becomes available as set forth in the notice from Landlord. In the event Tenant agrees to lease the Additional Space within such ten (10) day period, Landlord and Tenant shall promptly execute an amount amendment to the Lease indicating the location and configuration of $13.80 per the Additional Space. The number of square feet of rentable square foot area of the Premises shall be measured and calculated by Landlord's architect in accordance with the provisions of Exhibit E attached hereto and shall be set forth in the amendment to the Lease. (d) In no event shall Tenant have the right to lease less than all of the Additional Space for the first 36 months and $15.04 per rentable square foot of available. (e) Tenant shall accept the Additional Space for in "as is" condition and Landlord shall have no obligation to provide Tenant with an improvement allowance with respect to the balance Additional Space. All work performed in the Additional Space shall be performed in accordance with the terms and provisions of the Primary Lease Term, as hereinafter definedthis Lease.