Common use of DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS Clause in Contracts

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same.

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] 5 (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Open by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science Open are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx ScienceOpen? [ ] YES [ ] NO If Yes, Xxxxxxx Science Open will provide a quote in respect of the same.

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same.. 7 [v.122016]

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same.]

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] 5 (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Open by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science Open are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx ScienceOpen? [ ] YES [ ] NO If Yes, Xxxxxxx Science Open will provide a quote in respect of the same.

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same.]

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same.

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITINGThe following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Does Assignor require assistance in having Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the English grammar and style Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect Author or Institution: Name of Institution: Travel Allowances for the same.Research:

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO SCHEDULE 1: DETAILS OF THE WORK 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same.]

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 2008 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 xxxx://xxx.xxx.xxx/en/20activities/10ethics/10helsinki/)? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one the 8th Edition of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedureshttp:// xxxxxx.xxx.xxx/xxxxxx/xxxx/Xxxxx-xxx-xxx-xxxx-xxx-xxx-xx- laboratory-animals.pdf) Act 1986 Amendment Regulations (SI 2012/3039). published by the National Academy of Sciences, The National Academies Press, Washington DC, United States of America? [ ] YES [ ] NO 6 [v.122016] CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are [ ] YES, I / We, the author(s)/reviewer(s)/editor(s), confirm that unless explicitly disclosed below there any actual, or potential, conflicts is no conflict of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same.:

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1.  Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 2008 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 xxxx://xxx.xxx.xxx/en/20activities/10ethics/10helsinki/)? [ ] YES [ ] NO  (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one the 8th Edition of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedureshttp:// xxxxxx.xxx.xxx/xxxxxx/xxxx/Xxxxx-xxx-xxx-xxxx-xxx-xxx- of-laboratory-animals.pdf) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] CONFLICTS OF INTEREST Conflicts published by the National Academy of interest arise when authorsSciences, reviewersThe National Academies Press, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content Washington DC, United States of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interestAmerica? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require requires assistance in having the English grammar and style of the Work work checked and improved by Xxxxxxx Science? ’s recommended language services of Eureka Science: [ ] YES [ ] NO If Yes, Xxxxxxx Eureka Science will provide a quote in respect of the same.. SCHEDULE 2: AUTHORS (include Principal/Corresponding Author details) NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: SCHEDULE 3: PROPOSED REFEREES NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: SCHEDULE 4: PUBLISHING

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITINGThe following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Does Assignor require assistance in having B1. Government Support for Research Work Please provide the English grammar following details: Type of Support Grant Number: Funds Received for Article Preparation and style Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Work checked and improved Author or Institution: Travel Allowances for the Research: Type of Support: Funds Received by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect the Author or Institution: Name of Institution: Travel Allowances for the same.Research:

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same.]

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? ?: [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same.

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same.. 7 [v.122016]

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s Judgement‟s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] 5 (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Open by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement‟s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science Open are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same.]

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in having the English grammar completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide that your institute did not receive any grants or funds for your work from a quote in respect of the samethird-party source.

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] 5 (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Open by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science Open are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same.]

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 2008 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 xxxx://xxx.xxx.xxx/en/20activities/10ethics/10helsinki/)? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one the 8th Edition of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedureshttp:// xxxxxx.xxx.xxx/xxxxxx/xxxx/Xxxxx-xxx-xxx-xxxx-xxx-xxx-xx- laboratory-animals.pdf) Act 1986 Amendment Regulations (SI 2012/3039). published by the National Academy of Sciences, The National Academies Press, Washington DC, United States of America? [ ] YES [ ] NO 6 [v.122016] CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are [ ] YES, I / We, the author(s)/reviewer(s)/editor(s), confirm that unless explicitly disclosed below there any actual, or potential, conflicts is no conflict of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require requires assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? : [ ] YES [ ] NO If Yes, Xxxxxxx Eureka Science will provide a quote in respect of the same.. SCHEDULE 2: AUTHORS (include Principal/Corresponding Author details) NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: SCHEDULE 3: PROPOSED REFEREES NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF JOURNAL(S): Clinical Anti-inflammatory & Anti-Allergy Drugs

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Anti-Cancer Agents in Medicinal Chemistry - ACAMC

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Catalysis - CCAT

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Molecular Pharmacology - CMP

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 7 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in having the English grammar completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide that your institute did not receive any grants or funds for your work from a quote in respect of the samethird-party source.

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 7 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same.]

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same.

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: B1. Government Support for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Cosmetic Science - COSCI

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: B1. Government Support for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Anti-Infective Agents- AIA

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 2008 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 xxxx://xxx.xxx.xxx/en/20activities/10ethics/10helsinki/)? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one the 8th Edition of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedureshttp:// xxxxxx.xxx.xxx/xxxxxx/xxxx/Xxxxx-xxx-xxx-xxxx-xxx-xxx-xx- laboratory-animals.pdf) Act 1986 Amendment Regulations (SI 2012/3039). published by the National Academy of Sciences, The National Academies Press, Washington DC, United States of America? [ ] YES [ ] NO 6 [v.122016] CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are [ ] YES, I / We, the author(s)/reviewer(s)/editor(s), confirm that unless explicitly disclosed below there any actual, or potential, conflicts is no conflict of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require requires assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? : [ ] YES [ ] NO If Yes, Xxxxxxx Eureka Science will provide a quote in respect of the same.. SCHEDULE 2: AUTHORS (include Principal/Corresponding Author details) NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: SCHEDULE 3: PROPOSED REFEREES NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF JOURNAL(S): Current Angiogenesis

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Gene Therapy -CGT

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 7 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: B1. Government Support for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 8 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 9 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 11 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Nanomedicine - CNANOM

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: B1. Government Support for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): The International Journal of Gastroneterology & Hepatology Diseases - IJGHD

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 2008 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 xxxx://xxx.xxx.xxx/en/20activities/10ethics/10helsinki/)? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one the 8th Edition of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedureshttp:// xxxxxx.xxx.xxx/xxxxxx/xxxx/Xxxxx-xxx-xxx- care-and-use-of-laboratory-animals.pdf) Act 1986 Amendment Regulations (SI 2012/3039). published by the National Academy of Sciences, The National Academies Press, Washington DC, United States of America? [ ] YES [ ] NO 6 [v.122016] CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] SCHEDULE 1: DETAILS OF THE WORK LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? ?: [ ] YES [ ] NO If Yes, Xxxxxxx Eureka Science will provide a quote in respect of the same.. SCHEDULE 2: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: SCHEDULE 3: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Neuroscience and Biomedical Engineering If the Assignor also wishes to have the Work made available on an open access basis, the Work “Open Access Plus” Option shall be made available on an open access basis, by Xxxxxxx Science, under the terms of the Creative Commons Attribution 4.0 International Public License CC-BY 4.0, subject to the payment of a one-off Fee of US$ 900. Does the Assignor also require such “open access” publication, and agree to pay the applicable Fee in accordance with the terms below? [ ] YES [ ] NO

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: B1. Government Support for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Drug Therapy - CDTH

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Pharmaceutical Design - CPD

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? ?: [ ] YES [ ] NO If Yes, Xxxxxxx Eureka Science will provide a quote in respect of the same.. SCHEDULE 1: DETAILS OF THE WORK SCHEDULE 2: ALL AUTHORS (include Corresponding Author details; add spaces for additional authors if required) NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: SCHEDULE 3: PUBLISHING TITLE OF PUBLICATION PLATFORM: The Open Sports Sciences Journal

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 2008 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 xxxx://xxx.xxx.xxx/en/20activities/10ethics/10helsinki/)? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one the 8th Edition of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedureshttp:// xxxxxx.xxx.xxx/xxxxxx/xxxx/Xxxxx-xxx-xxx- care-and-use-of-laboratory-animals.pdf) Act 1986 Amendment Regulations (SI 2012/3039). published by the National Academy of Sciences, The National Academies Press, Washington DC, United States of America? [ ] YES [ ] NO 6 [v.122016] CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? ?: [ ] YES [ ] NO If Yes, Xxxxxxx Eureka Science will provide a quote in respect of the same.. SCHEDULE 2: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: SCHEDULE 3: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Biomarkers If the Assignor also wishes to have the Work made available on an open access basis, the Work “Open Access Plus” Option shall be made available on an open access basis, by Xxxxxxx Science, under the terms of the Creative Commons Attribution 4.0 International Public License CC-BY 4.0, subject to the payment of a one-off Fee of US$ 900 Does the Assignor also require such “open access” publication, and agree to pay the applicable Fee in accordance with the terms below? [ ] YES [ ] NO

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? ?: [ ] YES [ ] NO If Yes, Xxxxxxx Eureka Science will provide a quote in respect of the same.. SCHEDULE 1: DETAILS OF THE WORK SCHEDULE 2: ALL AUTHORS (include Corresponding Author details; add spaces for additional authors if required) NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: SCHEDULE 3: PUBLISHING TITLE OF PUBLICATION PLATFORM: The Open Fish Science Journal

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 2008 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 xxxx://xxx.xxx.xxx/en/20activities/10ethics/10helsinki/)? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one the 8th Edition of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedureshttp:// xxxxxx.xxx.xxx/xxxxxx/xxxx/Xxxxx-xxx-xxx- care-and-use-of-laboratory-animals.pdf) Act 1986 Amendment Regulations (SI 2012/3039). published by the National Academy of Sciences, The National Academies Press, Washington DC, United States of America? [ ] YES [ ] NO 6 [v.122016] CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] SCHEDULE 1: DETAILS OF THE WORK LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? ?: [ ] YES [ ] NO If Yes, Xxxxxxx Eureka Science will provide a quote in respect of the same.. SCHEDULE 2: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: SCHEDULE 3: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Recent Patents on Endocrine, Metabolic & Immune Drug Discovery “Open Access Plus” Option If the Assignor also wishes to have the Work made available on an open access basis, the Work shall be made available on an open access basis, by Xxxxxxx Science, under the terms of the Creative Commons Attribution 4.0 International Public License CC-BY 4.0, subject to the payment of a one-off Fee of US$ 900 Does the Assignor also require such “open access” publication, and agree to pay the applicable Fee in accordance with the terms below? [ ] YES [ ] NO

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] N O CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same.]

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Medical Imaging- CMIM

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 2008 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 xxxx://xxx.xxx.xxx/en/20activities/10ethics/10helsinki/)? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one the 8th Edition of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedureshttp:// xxxxxx.xxx.xxx/xxxxxx/xxxx/Xxxxx-xxx-xxx-xxxx-xxx-xxx-xx- laboratory-animals.pdf) Act 1986 Amendment Regulations (SI 2012/3039). published by the National Academy of Sciences, The National Academies Press, Washington DC, United States of America? [ ] YES [ ] NO 6 [v.122016] CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are [ ] YES, I / We, the author(s)/reviewer(s)/editor(s), confirm that unless explicitly disclosed below there any actual, or potential, conflicts is no conflict of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require requires assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? : [ ] YES [ ] NO If Yes, Xxxxxxx Eureka Science will provide a quote in respect of the same.. SCHEDULE 2: AUTHORS (include Principal/Corresponding Author details) NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: SCHEDULE 3: PROPOSED REFEREES NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF JOURNAL(S): Inflammation & Allergy – Drug Targets

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Vascular Pharmacology - CVP

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: B1. Government Support for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Respiratory Medicine Reviews - CRMR

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] 5 (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same.

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? ?: [ ] YES [ ] NO If Yes, Xxxxxxx Eureka Science will provide a quote in respect of the same.. SCHEDULE 1: DETAILS OF THE WORK SCHEDULE 2: ALL AUTHORS (include Corresponding Author details; add spaces for additional authors if required) NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: SCHEDULE 3: PUBLISHING TITLE OF PUBLICATION PLATFORM: The Open Clinical Biochemistry Journal

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Protein & Peptide Letters - PPL

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): New Advances on Endocrine Metabolic and Immune Diseases - NAEMID

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? ?: [ ] YES [ ] NO If Yes, Xxxxxxx Eureka Science will provide a quote in respect of the same.. SCHEDULE 1: DETAILS OF THE WORK SCHEDULE 2: ALL AUTHORS (include Corresponding Author details; add spaces for additional authors if required) NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: SCHEDULE 3: PUBLISHING TITLE OF PUBLICATION PLATFORM: The Open Clinical Biochemistry Journal

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: B1. Government Support for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Bioinformatics - CBIO

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: B1. Government Support for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Combinatorial Chemistry & High Throughput Screening - CCHTS

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Letters in Drug Design & Discovery- LDDD

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: B1. Government Support for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Cancer Therapy Reviews - CCTR

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 2008 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 xxxx://xxx.xxx.xxx/en/20activities/10ethics/10helsinki/)? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one the 8th Edition of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedureshttp:// xxxxxx.xxx.xxx/xxxxxx/xxxx/Xxxxx-xxx-xxx-xxxx-xxx-xxx-xx- laboratory-animals.pdf) Act 1986 Amendment Regulations (SI 2012/3039). published by the National Academy of Sciences, The National Academies Press, Washington DC, United States of America? [ ] YES [ ] NO 6 [v.122016] CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are [ ] YES, I / We, the author(s)/reviewer(s)/editor(s), confirm that unless explicitly disclosed below there any actual, or potential, conflicts is no conflict of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require requires assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? : [ ] YES [ ] NO If Yes, Xxxxxxx Eureka Science will provide a quote in respect of the same.. SCHEDULE 2: AUTHORS (include Principal/Corresponding Author details) NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: SCHEDULE 3: PROPOSED REFEREES NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF JOURNAL(S): Recent Patents on Nanomedicine

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 7 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same.

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Indian Science-CIS

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Applied Drug Research, Clinical Trials and Regulatory Affairs- ADCTA

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: B1. Government Support for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Drug Discovery Technologies - CDDT

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] 5 (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same.

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Pediatric Reviews – CPR

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Journal of Environmental Materials and Sustainable Energy- JESE

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Proteomics-CP

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: B1. Government Support for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Pharmacogenomics and Personalized Medicine (CPPM)

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Topics in Medicinal Chemistry - CTMC

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: B1. Government Support for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Pharmaceutical Biotechnology - CPB

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Drug Research Reviews - CDRR

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Recent Advances in Food, Nutrition & Agriculture - FNA

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Drug Delivery- CDD

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: B1. Government Support for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Reviews in Clinical and Experimental Pharmacology- CRCEP

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Recent Advances in Drug Delivery and Formulation - RADDF

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? ?: [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same.

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Adolescent Psychiatry - APS

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): MicroRNA

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 2008 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 xxxx://xxx.xxx.xxx/en/20activities/10ethics/10helsinki/)? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one the 8th Edition of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedureshttp:// xxxxxx.xxx.xxx/xxxxxx/xxxx/Xxxxx-xxx-xxx-xxxx-xxx-xxx-xx-xxxxxxxxxx-xxxxxxx.xxx) Act 1986 Amendment Regulations (SI 2012/3039). published by the National Academy of Sciences, The National Academies Press, Washington DC, United States of America? [ ] YES [ ] NO 6 [v.122016] CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? ?: [ ] YES [ ] NO If Yes, Xxxxxxx Eureka Science will provide a quote in respect of the same.. SCHEDULE 2: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: SCHEDULE 3: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Metabolomics “Open Access Plus” Option If the Assignor also wishes to have the Work made available on an open access basis, the Work shall be made available on an open access basis, by Xxxxxxx Science, under the terms of the Creative Commons Attribution 4.0 International Public License CC-BY 4.0, subject to the payment of a one-off Fee of US$ 1250. Does the Assignor also require such “open access” publication, and agree to pay the applicable Fee in accordance with the terms below? [ ] YES [ ] NO PAYMENT TERMS: Xxxxxxx Science shall invoice the Assignor in respect of the Fee. 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DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: B1. Government Support for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Nanotoxicity and Prevention - CNTP

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Open by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science Open are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx ScienceOpen? [ ] YES [ ] NO If Yes, Xxxxxxx Science Open will provide a quote in respect of the same.

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: B1. Government Support for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Letters in Drug Design & Discovery- LDDD

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Drug Safety - CDS

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: B1. Government Support for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Nanoscience & Nanotechnology-Asia- NNA

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Psychiatry Research and Reviews - CPRR

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 2008 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 xxxx://xxx.xxx.xxx/en/20activities/10ethics/10helsinki/)? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one the 8th Edition of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedureshttp:// xxxxxx.xxx.xxx/xxxxxx/xxxx/Xxxxx-xxx-xxx-xxxx-xxx-xxx-xx- laboratory-animals.pdf) Act 1986 Amendment Regulations (SI 2012/3039). published by the National Academy of Sciences, The National Academies Press, Washington DC, United States of America? [ ] YES [ ] NO 6 [v.122016] CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are [ ] YES, I / We, the author(s)/reviewer(s)/editor(s), confirm that unless explicitly disclosed below there any actual, or potential, conflicts is no conflict of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require requires assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? : [ ] YES [ ] NO If Yes, Xxxxxxx Eureka Science will provide a quote in respect of the same.. SCHEDULE 2: AUTHORS (include Principal/Corresponding Author details) NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: SCHEDULE 3: PROPOSED REFEREES NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF JOURNAL(S): Recent Advances in Cardiovascular Drug Discovery

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? ?: [ ] YES [ ] NO If Yes, Xxxxxxx Eureka Science will provide a quote in respect of the same.. SCHEDULE 1: DETAILS OF THE WORK SCHEDULE 2: ALL AUTHORS (include Corresponding Author details; add spaces for additional authors if required) NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: SCHEDULE 3: PUBLISHING TITLE OF PUBLICATION PLATFORM: The Open Immunology Journal

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: B1. Government Support for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Neurovascular Research - CNR

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 2008 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 xxxx://xxx.xxx.xxx/en/20activities/10ethics/10helsinki/)? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one the 8th Edition of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedureshttp:// xxxxxx.xxx.xxx/xxxxxx/xxxx/Xxxxx-xxx-xxx- care-and-use-of-laboratory-animals.pdf) Act 1986 Amendment Regulations (SI 2012/3039). published by the National Academy of Sciences, The National Academies Press, Washington DC, United States of America? [ ] YES [ ] NO 6 [v.122016] CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? ?: [ ] YES [ ] NO If Yes, Xxxxxxx Eureka Science will provide a quote in respect of the same.. SCHEDULE 2: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: SCHEDULE 3: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Regenerative Medicine If the Assignor also wishes to have the Work made available on an open access basis, the Work “Open Access Plus” Option shall be made available on an open access basis, by Xxxxxxx Science, under the terms of the Creative Commons Attribution 4.0 International Public License CC-BY 4.0, subject to the payment of a one-off Fee of US$ 900 Does the Assignor also require such “open access” publication, and agree to pay the applicable Fee in accordance with the terms below? [ ] YES [ ] NO

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 7 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 8 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 9 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Current Cardiology Reviews - CCR

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? ?: [ ] YES [ ] NO If Yes, Xxxxxxx Eureka Science will provide a quote in respect of the same.. SCHEDULE 1: DETAILS OF THE WORK SCHEDULE 2: ALL AUTHORS (include Corresponding Author details; add spaces for additional authors if required) NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: SCHEDULE 3: PUBLISHING TITLE OF PUBLICATION PLATFORM: Open Pharmaceutical Sciences Journal

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? ?: [ ] YES [ ] NO If Yes, Xxxxxxx Eureka Science will provide a quote in respect of the same. SCHEDULE 1: DETAILS OF THE WORK SCHEDULE 2: ALL AUTHORS (include Corresponding Author details; add spaces for additional authors if required) NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: NAME: AFFILIATION: EMAIL: SCHEDULE 3: PUBLISHING TITLE OF PUBLICATION PLATFORM: Current Chemical Genomics and Translational Medicine “FEE”: [XXXXXXX TO INSERT AMOUNT USD] payable in respect of the publication by Xxxxxxx Open of the Work via the above publication platform in accordance with the terms below.

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 [v.122016] CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same.

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 7 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] The following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Author or Institution: Name of Institution: Travel Allowances for the Research: 8 [v.122016] LANGUAGE AND EDITING: Does Assignor require assistance in having the English grammar and style of the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect of the same. US GOVERNMENT EMPLOYEES / CONTRACTORS Was any Author a US government employee when the Work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) Was Author an independent contractor to the US government when the work was created? [ ] YES [ ] NO (If Yes, the relevant Author/s must each execute and submit to Xxxxxxx Science, using Xxxxxxx Science’s form letter, the supplemental terms applicable to the Author.) 9 [v.122016] SCHEDULE 3: ALL AUTHORS (include Principal/Corresponding Author details; add spaces for additional authors if required) Author contribution: Please specify the contribution of each author to the paper, e.g. study concept or design, data collection, data analysis or interpretation, writing the paper, others, who have contributed in other ways, should be listed as contributors. NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 10 [v.122016] NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: NAME: AFFILIATION: EMAIL: AUTHOR CONTRIBUTION: Study Concept or Design Data Collection Data Analysis or Interpretation Writing the Paper Others ORCID: We agree to the terms as set out in the Agreement. Signed by: 11 [v.122016] SCHEDULE 4: PUBLISHING PUBLICATION VIA JOURNAL TITLE OF SUBSCRIPTION JOURNAL(S): Recent Advances in Inflammation & Allergy Drug Discovery- RAIAD

DECLARATION OF COMPLIANCE WITH APPLICABLE STANDARDS. 1. Does the Work report experiments involving human subjects? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013 (xxxx://xxxxxx.xxx.xxx/ecodes/node/3931 )? [ ] YES [ ] NO (If Yes, the Assignor must submit a copy of the approval and consent-to-disclose form to Xxxxxxx Science Publishers by fax or email.) Please state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number. (If No, the Assignor must mention an institutional or regional guideline.) 2. Does the Work report experiments involving animals? [ ] YES [ ] NO  • If Yes, were the reported experiments in accordance with the standards set forth in one of below national guidelines and regulations: o The US National Research Council's "Guide for the Care and Use of Laboratory Animals," o The US Public Health Service's "Policy on Humane Care and Use of Laboratory Animals," and "Guide for the Care and Use of Laboratory Animals." o UK : the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039). [ ] YES [ ] NO 6 7 [v.122016] (If Yes, the Assignor must submit a copy of the approval to Xxxxxxx Science Publishers by fax or email and please also state whether Ethical Approval was given, by whom and the relevant Judgement’s reference number.) (If No, the Assignor must mention an institutional or regional guideline. CONFLICTS OF INTEREST Conflicts of interest arise when authors, reviewers, or editors have interests (such as financial or personal interests) that are not made clear and that may influence their judgment on the content of their work. Authors and editors who submit work for publication with Xxxxxxx Science are required to disclose and acknowledge all forms of financial support relating to the work to be published, all commercial or financial involvement that might present an appearance of a conflict of interest in respect of the work, and all agreements relating to sponsorship of any research upon which the work is based. Are there any actual, or potential, conflicts of interest? [ ] YES [ ] NO If Yes, details of the actual or potential conflicts of interest must be set-out in the spaces provided below. DISCLOSURE REGARDING ACTUAL OR POTENTIAL CONFLICTS OF INTEREST: [INSERT] DISCLOSURE REGARDING THIRD PARTY FINANCIAL CONTRIBUTIONS: [INSERT] LANGUAGE AND EDITINGThe following details pertain to knowing about the resources, which you directly or indirectly received (from your university or institution supporting you in the completion of your research. However, if you select “No” here, then it refers to you carrying out the work without receiving any third-party financial support, implicating that your study work was carried out using the grants from your own institute (that pays your salary) and that your institute did not receive any grants or funds for your work from a third-party source. B1. Commercial Sponsorship for Research Work Please provide the following details: Does Assignor require assistance in having Type of Support Grant Number: Funds Received for Article Preparation and Reviewing: Name of Institution: Support Provided for Article Writing Assistance, for Drugs, Equipment etc: Funds Received by the English grammar and style Author or Institution: Travel Allowances for the Research: B1. Government Support for Research Work Please provide the following details: Type of Support: Funds Received by the Work checked and improved by Xxxxxxx Science? [ ] YES [ ] NO If Yes, Xxxxxxx Science will provide a quote in respect Author or Institution: Name of Institution: Travel Allowances for the same.Research: