Common use of Collaborative agreement Clause in Contracts

Collaborative agreement. The customer identifies the gene to be targeted. MutaMouse will assess gene structure, alternative transcripts and functional domains, and will design a KO strategy. The customer will be consulted with on the strategy, and will have the final decision. MutaMouse will then design and test CrispR for this site. If the site proves unsuitable, MutaMouse will design an alternative strategy in consultation with the customer and repeat. When functional CrispR are identified MutaMouse will run zygote injection. Consultation is no extra price. MutaMouse should be listed in the acknowledgement of resulting publications, and ▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇ and ▇▇▇▇▇▇ ▇▇▇▇▇▇ should be listed as middle authors on the first publication. Expected Date of Delivery of the mouse production: Within 3-9 months. (The Date of Delivery may be adversely affected by a number of issues such as high number of requests, technical issues, lack of supplies, etc. Therefore, the date of delivery is non-binding, but the client will be informed in advance such a case). I, the undersigned, agree to and have read the following items of information: The client agrees with the charges listed for this service (see addendum A to this service agreement form). The client agrees to pay in advance upon signature of this registration form. Final invoicing will be done upon finalization of the services. Invoices are payable within 30 days upon receipt of the invoice from KU LEUVEN or VIB. The agreement becomes active following payment. By signing the present service agreement form, the client agrees to be bound by the terms and conditions of KU Leuven or VIB, attached hereto in Addendum B. MutaMouse cannot be held responsible for problems that are outside of the control of the experimentator and may influence the experiment such as, but not exclusively, toxicity of plasmid elements to bacteria, incorrect provided plasmid maps, gene locus accessibility for gene targeting, etc. In the case that no working crRNA can be found, the client will receive a report on the tested crRNA (>10) and a 50% refund on the KO full-service fee. Full services comprise MutaMouse internal services only. They exclude services outside MutaMouse such as DNA synthesis, project-specific plasmid orders, oligonucleotide synthesis and sequencing services. Pronuclear/Cytoplasmic injection price is calculated per session, all zygotes obtained from 5 superovulated C57Bl6J donor mice will be injected and transferred after injection into CD1 acceptor mice. By this we will obtain at least 5 pups/session. No guarantee is made on viability or genotype of the offspring. The use of an alternative donor strain can influence the price and can only be considered after discussion. Please download and sign the respective microinjection agreement form. If no founders are born in the first zygote injection session, a second session will be run for free. If a third or fourth session is desired by the user, these will be run at 50% of the cost of this agreement. The mentioned list prices in Addendum A are exclusive of VAT. External invoices will be subject to 18% overhead which is not included yet in the list price. Consultation (free for collaborations), per hour € 100 € 100 € 150 CrispR design, production subcloning and testing (>10) included included included Zygote injection included included included Generation of KO mice € 4,428 € 6,855 € 10,283 Prices can be subject to change without prior notification. Therefore, always download the latest registration form from the MutaMouse website before final ordering of the service: ▇▇▇▇▇://▇▇▇▇▇▇▇.▇▇▇▇▇▇▇▇.▇▇/english/corefacilities/mutamouse/ko-mouse-generation For the following Terms and conditions, the “Providing Party” shall be KU Leuven for services rendered by KU Leuven and/or VIB for services rendered by VIB, or both if applicable. The Providing Party shall deliver services to the client according to the present terms and conditions, to which the client agrees. The terms and conditions shall prevail over any and all prior agreements, orally and in writing. Even if stated otherwise by the client, any terms and conditions of the client shall in any case be held null and void. All prices indicated are without V.A.T.. Invoices shall be payable within 30 days after invoice date, unless stated otherwise on the invoice. In case of late or non-payment of due invoices by the client, the Providing Party shall be entitled to suspend the performance of its Services to the client for as long as the invoices are not paid. The Providing Party shall be entitled to charge the client an interest on the amount of any invoice not paid on its due date, in accordance with the terms stated on the invoice or in the event no terms are stated on the invoice, in accordance with applicable law.

Collaborative agreement. The customer identifies describes the gene to be targeteddesired outcome. MutaMouse will assess alternative strategies for reaching the desired outcome, considering gene structure, protein structure, alternative transcripts and functional domainstranscripts, and will design a KO strategyetc. The customer will be consulted with on the strategy, and will have the final decision. Multiple rounds of consultation will be provided for free to create an optimal design for the customer. MutaMouse will then design and test CrispR for this site. If implement the site proves unsuitable, MutaMouse will design an alternative strategy in consultation with the customer and repeat. When functional CrispR are identified MutaMouse will run zygote injection. Consultation is no extra pricestrategy. MutaMouse should be listed in the acknowledgement of resulting publications, and ▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇ and ▇▇▇▇▇▇ ▇▇▇▇▇▇ should be listed as middle authors on the first publication. Additional information is required: Aim of experiment (knock-in, KIKO, fate-mapping, etc) If knock-in, specify if there is a desired location (e.g. at N-terminal or C-terminal insertion, etc) Other relevant information Donor/screening designed by client Yes / No Donor fragment ☐ Provided by customer ☐ Synthesized (extra cost) Expected Date of Delivery of the mouse production/cell line service: Within 36-9 12 months. (The Date of Delivery may be adversely affected by a number of issues such as high number of requests, technical issues, lack of supplies, etc. Therefore, the date of delivery is non-binding, but the client will be informed in advance in such a case). I, the undersigned, agree to and have read the following items of information: The client agrees with the charges listed for this service (see addendum A to this service agreement form). The client agrees to pay in advance upon signature of this registration form. Final invoicing will be done upon finalization of the services. Invoices are payable within 30 days upon receipt of the invoice from KU LEUVEN or VIB. The agreement becomes active following payment. By signing the present service agreement form, the client agrees to be bound by the terms and conditions of KU Leuven or VIB, attached hereto in Addendum B. MutaMouse cannot be held responsible for problems that are outside of the control of the experimentator and may influence the experiment such as, but not exclusively, toxicity of plasmid elements to bacteria, incorrect provided plasmid maps, gene locus accessibility for gene targeting, etc. In the case that no working crRNA can edited ES cells cannot be foundgenerated or are not viable, the client will receive a report on the tested crRNA (>10) and cleavage efficiency, and receive a 50% refund on the KO KI full-service fee. Pricing for cloning support excludes DNA fragment and oligonucleotide synthesis, project-specific plasmid orders, sequencing services and cloning kits other than restriction enzymes. Full services comprise MutaMouse internal services only. They exclude services outside MutaMouse such as DNA synthesis, project-specific plasmid orders, oligonucleotide synthesis and sequencing services. Pronuclear/Cytoplasmic Blastocyst injections guarantee the delivery of 5 chimeric pups. Please download and sign the respective microinjection agreement form. At MutaMouse we use JM8.A3 mouse embryonic stem cells for gene targeting purposes. We strongly recommend the injection price is calculated per session, all zygotes obtained from 5 superovulated C57Bl6J donor mice will be injected and transferred after injection into CD1 acceptor mice. By this we will obtain at least 5 pups/session. No guarantee is made on viability or genotype of multiple mutant ES cell clones to increase the chance for germline transmission of the offspringmutant allele. Standard the donor strain is CD1. The use of an alternative donor strain can will influence the price and can only be considered after discussion. Please download and sign Blastocyst injection: 2 injection days/clone. We prefer to work with 2-3 different ES cell clones to increase the respective microinjection agreement formchances for obtaining chimeric mice. No germline transmission is guaranteed. If no founders are born in the first zygote injection sessiongermline transmission is not achieved, a second session round of blastocyst injection will be run performed for free. If a the customer requires third or and fourth session is desired by the userrounds of blastocyst injection, these each will be run performed at 50% of the cost of this current agreement. The mentioned list prices in Addendum A are exclusive of VAT. External invoices will be subject to 18% overhead which is not included yet in the list price. Consultation (free for collaborations), per hour € 100 € 100 € 150 CrispR design, production subcloning and testing (>10) included included included Zygote ESC transfection, sorting/selection and testing included included included Blastocyst injection included included included Generation of KO ▇▇▇▇ KI mice (excluding donor DNA) € 4,428 9,900 € 6,855 14,800 € 10,283 22,200 Generation of other KI mice (excluding donor DNA) € 13,406 € 19,312 € 28,968 Donor DNA is to be provided by the customer, or synthesized by a third party (arranged by ▇▇▇▇▇▇▇▇▇). Donor synthesis is at the cost of the customer, and is dependent on the construct. Prices can be subject to change without prior notification. Therefore, always download the latest registration form from the MutaMouse website before final ordering of the service: ▇▇▇▇▇://▇▇▇▇▇▇▇.▇▇▇▇▇▇▇▇.▇▇/english/corefacilities/mutamouse/koki-mouse-generation For the following Terms and conditions, the “Providing Party” shall be KU Leuven for services rendered by KU Leuven and/or VIB for services rendered by VIB, or both if applicable. The Providing Party shall deliver services to the client according to the present terms and conditions, to which the client agrees. The terms and conditions shall prevail over any and all prior agreements, orally and in writing. Even if stated otherwise by the client, any terms and conditions of the client shall in any case be held null and void. All prices indicated are without V.A.T.. Invoices shall be payable within 30 days after invoice date, unless stated otherwise on the invoice. In case of late or non-payment of due invoices by the client, the Providing Party shall be entitled to suspend the performance of its Services to the client for as long as the invoices are not paid. The Providing Party shall be entitled to charge the client an interest on the amount of any invoice not paid on its due date, in accordance with the terms stated on the invoice or in the event no terms are stated on the invoice, in accordance with applicable law.

Collaborative agreement. The customer identifies describes the gene to be targeteddesired outcome. MutaMouse will assess alternative strategies for reaching the desired outcome, considering gene structure, protein structure, alternative transcripts and functional domainstranscripts, and will design a KO strategyetc. The customer will be consulted with on the strategy, and will have the final decision. Multiple rounds of consultation will be provided for free to create an optimal design for the customer. MutaMouse will then design and test CrispR for this site. If implement the site proves unsuitable, MutaMouse will design an alternative strategy in consultation with the customer and repeat. When functional CrispR are identified MutaMouse will run zygote injection. Consultation is no extra pricestrategy. MutaMouse should be listed in the acknowledgement of resulting publications, and ▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇ and ▇▇▇▇▇▇ ▇▇▇▇▇▇ should be listed as middle authors on the first publication. Additional information is required: Aim of experiment (knock-in, KIKO, fate-mapping, etc) If knock-in, specify if there is a desired location (e.g. at N-terminal or C-terminal insertion, etc) Other relevant information Donor/screening designed by client Yes / No Donor fragment ☐ Provided by customer ☐ Synthesized (extra cost) Expected Date of Delivery of the mouse production/cell line service: Within 3-9 months. (The Date of Delivery may be adversely affected by a number of issues such as high number of requests, technical issues, lack of supplies, etc. Therefore, the date of delivery is non-binding, but the client will be informed in advance such a case). I, the undersigned, agree to and have read the following items of information: The client agrees with the charges listed for this service (see addendum A to this service agreement form). The client agrees to pay in advance upon signature of this registration form. Final invoicing will be done upon finalization of the services. Invoices are payable within 30 days upon receipt of the invoice from KU LEUVEN or VIB. The agreement becomes active following payment. By signing the present service agreement form, the client agrees to be bound by the terms and conditions of KU Leuven or VIB, attached hereto in Addendum B. MutaMouse cannot be held responsible for problems that are outside of the control of the experimentator and may influence the experiment such as, but not exclusively, toxicity of plasmid elements to bacteria, incorrect provided plasmid maps, gene locus accessibility for gene targeting, etc. In the case that no working crRNA can be found, the client will receive a report on the tested crRNA (>10) Pricing for cloning support excludes DNA fragment and a 50% refund on the KO full-service fee. Full services comprise MutaMouse internal services only. They exclude services outside MutaMouse such as DNA oligonucleotide synthesis, project-specific plasmid orders, oligonucleotide synthesis sequencing services and sequencing servicescloning kits other than restriction enzymes. Pronuclear/Cytoplasmic injection price is calculated per session, all zygotes obtained from 5 superovulated C57Bl6J donor mice will be injected and transferred after injection into CD1 acceptor mice. By this At MutaMouse we will obtain at least 5 pups/session. No guarantee is made on viability or genotype of the offspring. The use of an alternative donor strain can influence the price and can only be considered after discussion. Please download and sign the respective microinjection agreement form. If no founders are born in the first zygote injection session, a second session will be run JM8.A3 mouse embryonic stem cells for free. If a third or fourth session is desired by the user, these will be run at 50% of the cost of this agreementgene targeting purposes. The mentioned list prices in Addendum A are exclusive of VAT. External invoices will be subject to 18% overhead which is not included yet in the list price. Consultation (free for collaborationscollaboration), per hour € 100 € 100 € 150 CrispR design, production subcloning and testing (>10) included included included Zygote injection included included included Generation of KO mice Included Included Included Fee for design, per day Included Included Included Fee for cloning services, per cloning step Included Included Included ESC transfection, sorting/selection and testing € 4,428 3,675 € 6,855 5,350 € 10,283 8,025 Prices can be subject to change without prior notification. Therefore, always download the latest registration form from the MutaMouse website before final ordering of the service: ▇▇▇▇▇://▇▇▇▇▇▇▇.▇▇▇▇▇▇▇▇.▇▇/english/corefacilities/mutamouse/ko-mouse-generation crispr For the following Terms and conditions, the “Providing Party” shall be KU Leuven for services rendered by KU Leuven and/or VIB for services rendered by VIB, or both if applicable. The Providing Party shall deliver services to the client according to the present terms and conditions, to which the client agrees. The terms and conditions shall prevail over any and all prior agreements, orally and in writing. Even if stated otherwise by the client, any terms and conditions of the client shall in any case be held null and void. All prices indicated are without V.A.T.. Invoices shall be payable within 30 days after invoice date, unless stated otherwise on the invoice. In case of late or non-payment of due invoices by the client, the Providing Party shall be entitled to suspend the performance of its Services to the client for as long as the invoices are not paid. The Providing Party shall be entitled to charge the client an interest on the amount of any invoice not paid on its due date, in accordance with the terms stated on the invoice or in the event no terms are stated on the invoice, in accordance with applicable law.