Common use of CERTAIN OBLIGATIONS OF HOLDERS AND BENEFICIAL Clause in Contracts

CERTAIN OBLIGATIONS OF HOLDERS AND BENEFICIAL. OWNERS OF RECEIPTS 14 SECTION 3.1 Proofs, Certificates and Other Information 14 SECTION 3.2 Liability for Taxes and Other Charges 14 SECTION 3.3 Representations and Warranties on Deposit of Shares 15 SECTION 3.4 Compliance with Information Requests 15 ARTICLE IV THE DEPOSITED SECURITIES 15 SECTION 4.1 Cash Distributions 15 SECTION 4.2 Distribution in Shares 16 SECTION 4.3 Elective Distributions in Cash or Shares 17 SECTION 4.4 Distribution of Rights to Purchase Shares 17 SECTION 4.5 Distributions Other Than Cash, Shares or Rights to Purchase Shares 19 SECTION 4.6 Conversion of Foreign Currency 20 SECTION 4.7 Fixing of Record Date 20 SECTION 4.8 Voting of Deposited Securities 21 SECTION 4.9 Changes Affecting Deposited Securities 22 SECTION 4.10 Available Information 23 SECTION 4.11 Reports 23 SECTION 4.12 List of Holders 23 SECTION 4.13 Taxation; Withholding 24 ARTICLE V. THE DEPOSITARY, THE CUSTODIAN AND THE COMPANY 25 SECTION 5.1 Maintenance of Office and Transfer Books by the Xxxxxxxxx 00 SECTION 5.2 Exoneration 25 SECTION 5.3 Standard of Care 26 SECTION 5.4 Resignation and Removal of the Depositary; Appointment of Successor Depositary 27 SECTION 5.5 The Custodian 28 SECTION 5.6 Notices and Reports 28 SECTION 5.7 Issuance of Additional Shares, ADSs etc. 29 SECTION 5.8 Indemnification 30 SECTION 5.9 Fees and Charges of Depositary 31 SECTION 5.10 Restricted Securities Owners/Ownership Restrictions 32 ARTICLE VI. AMENDMENT AND TERMINATION 33 SECTION 6.1 Amendment/Supplement 33 SECTION 6.2 Termination 34 ARTICLE VII. MISCELLANEOUS 35 SECTION 7.1 Counterparts 35 SECTION 7.2 No Third-Party Beneficiaries 35 SECTION 7.3 Severability 35 SECTION 7.4 Holders and Beneficial Owners as Parties; Binding Effect 35 SECTION 7.5 Notices 35 SECTION 7.6 Governing Law and Jurisdiction 36 SECTION 7.7 Assignment 38 SECTION 7.8 Agents 38 SECTION 7.9 Exclusivity 38 SECTION 7.10 Compliance with U.S. Securities Laws 38 SECTION 7.11 Titles 38 EXHIBIT A A-1 EXHIBIT B B-1

CERTAIN OBLIGATIONS OF HOLDERS AND BENEFICIAL. OWNERS OF RECEIPTS 14 11 SECTION 3.1 Proofs, Certificates and Other Information 14 11 SECTION 3.2 Liability for Taxes and Other Charges 14 12 SECTION 3.3 Representations and Warranties on Deposit of Shares 15 13 SECTION 3.4 Compliance with Information Requests 15 13 ARTICLE IV THE DEPOSITED SECURITIES 15 SECURITIES. 14 SECTION 4.1 Cash Distributions 15 14 SECTION 4.2 Distribution in Shares 16 14 SECTION 4.3 Elective Distributions in Cash or Shares 17 15 SECTION 4.4 Distribution of Rights to Purchase Shares 17 15 SECTION 4.5 Distributions Other Than Cash, Shares or Rights to Purchase Shares 19 17 SECTION 4.6 Conversion of Foreign Currency 20 18 SECTION 4.7 Fixing of Record Date 20 18 SECTION 4.8 Voting of Deposited Securities 21 19 SECTION 4.9 Changes Affecting Deposited Securities 22 21 SECTION 4.10 Available Information 23 21 SECTION 4.11 Reports 23 21 SECTION 4.12 List of Holders 23 22 SECTION 4.13 Taxation; Withholding 24 22 SECTION 4.14 Affiliates etc 23 ARTICLE V. THE DEPOSITARY, THE CUSTODIAN AND THE COMPANY 25 23 SECTION 5.1 Maintenance of Office and Transfer Books by the Xxxxxxxxx 00 Registrar 23 SECTION 5.2 Exoneration 25 24 SECTION 5.3 Standard of Care 26 25 SECTION 5.4 Resignation and Removal of the Depositary; Appointment of Successor Depositary 27 26 SECTION 5.5 The Custodian 28 27 SECTION 5.6 Notices and Reports 28 27 SECTION 5.7 Issuance of Additional Shares, ADSs etc. 29 28 SECTION 5.8 Indemnification 30 29 SECTION 5.9 Fees and Charges of Depositary 31 30 SECTION 5.10 Restricted Securities Owners/Ownership Restrictions 32 31 ARTICLE VI. AMENDMENT AND TERMINATION 33 31 SECTION 6.1 Amendment/Supplement 33 31 SECTION 6.2 Termination 34 32 ARTICLE VII. MISCELLANEOUS 35 33 SECTION 7.1 Counterparts 35 33 SECTION 7.2 No Third-Third Party Beneficiaries 35 33 SECTION 7.3 Severability 35 34 SECTION 7.4 Holders and Beneficial Owners as Parties; Binding Effect 35 34 SECTION 7.5 Notices 35 34 SECTION 7.6 Governing Law and Jurisdiction 36 34 SECTION 7.7 Assignment 38 36 SECTION 7.8 Agents 38 36 SECTION 7.9 Exclusivity 38 36 SECTION 7.10 Compliance with U.S. Securities Laws 38 36 SECTION 7.11 Titles 38 37 EXHIBIT A A-1 39 EXHIBIT B B-148

CERTAIN OBLIGATIONS OF HOLDERS AND BENEFICIAL. OWNERS OF RECEIPTS 14 SECTION ADSs 18 Section 3.1 Proofs, Certificates and Other Information 14 SECTION 18 Section 3.2 Liability for Taxes and Other Charges 14 SECTION 19 Section 3.3 Representations and Warranties on Deposit of Shares 15 SECTION 19 Section 3.4 Compliance with Information Requests 15 19 Section 3.5 Ownership Restrictions 20 Section 3.6 Reporting Obligations and Regulatory Approvals 21 ARTICLE IV THE DEPOSITED SECURITIES 15 SECTION 21 Section 4.1 Cash Distributions 15 SECTION 21 Section 4.2 Distribution in Shares 16 SECTION 22 Section 4.3 Elective Distributions in Cash or Shares 17 SECTION 23 Section 4.4 Distribution of Rights to Purchase Shares 17 SECTION Additional ADSs 24 Section 4.5 Distributions Other Than Cash, Shares or Rights to Purchase Shares 19 SECTION 25 Section 4.6 Distributions with Respect to Deposited Securities in Bearer Form 26 Section 4.7 Redemption 26 Section 4.8 Conversion of Foreign Currency 20 SECTION 4.7 27 Section 4.9 Fixing of ADS Record Date 20 SECTION 4.8 28 Section 4.10 Voting of Deposited Securities 21 SECTION 4.9 28 Section 4.11 Changes Affecting Deposited Securities 22 SECTION 4.10 30 Section 4.12 Available Information 23 SECTION 4.11 31 Section 4.13 Reports 23 SECTION 4.12 31 Section 4.14 List of Holders 23 SECTION 4.13 Taxation; Withholding 24 31 Section 4.15 Taxation 31 ARTICLE V. V THE DEPOSITARY, THE CUSTODIAN AND THE COMPANY 25 SECTION 33 Section 5.1 Maintenance of Office and Transfer Books by the Xxxxxxxxx Rxxxxxxxx 00 SECTION Section 5.2 Exoneration 25 SECTION 33 Section 5.3 Standard of Care 26 SECTION 34 Section 5.4 Resignation and Removal of the Depositary; Appointment of Successor Depositary 27 SECTION 35 Section 5.5 The Custodian 28 SECTION 35 Section 5.6 Notices and Reports 28 SECTION 36 Section 5.7 Issuance of Additional Shares, ADSs etc. 29 SECTION etc 37 Section 5.8 Indemnification 30 SECTION 38 Section 5.9 ADS Fees and Charges of Depositary 31 SECTION 39 Section 5.10 Pre-Release Transactions 40 Section 5.11 Restricted Securities Owners/Ownership Restrictions 32 Owners 41 ARTICLE VI. VI AMENDMENT AND TERMINATION 33 SECTION 41 Section 6.1 Amendment/Supplement 33 SECTION 41 Section 6.2 Termination 34 42 ARTICLE VII. VII MISCELLANEOUS 35 SECTION 43 Section 7.1 Counterparts 35 SECTION 43 Section 7.2 No Third-Party Beneficiaries 35 SECTION Beneficiaries/Acknowledgments 43 Section 7.3 Severability 35 SECTION 43 Section 7.4 Holders and Beneficial Owners as Parties; Binding Effect 35 SECTION 44 Section 7.5 Notices 35 SECTION 44 Section 7.6 Governing Law and Jurisdiction 36 SECTION 45 Section 7.7 Assignment 38 SECTION 46 Section 7.8 Agents 38 SECTION 7.9 Exclusivity 38 SECTION 7.10 Compliance with U.S. Securities Laws 38 SECTION 7.11 46 Section 7.9 English Law References 47 Section 7.10 Titles 38 and References 47 EXHIBIT A FORM OF ADR A-1 EXHIBIT B B-1FEE SCHEDULE ADS FEES AND RELATED CHARGES B-1 DEPOSIT AGREEMENT DEPOSIT AGREEMENT, dated as of June 26, 2018, by and among (i) Autolus Therapeutics plc, a public limited company incorporated under the laws of England and Wales, and its successors (the “Company”), (ii) CITIBANK, N.A., a national banking association organized under the laws of the United States of America (“Citibank”) acting in its capacity as depositary, and any successor depositary hereunder (Citibank in such capacity, the “Depositary”), and (iii) all Holders and Beneficial Owners of American Depositary Shares issued hereunder (all such capitalized terms as hereinafter defined).

CERTAIN OBLIGATIONS OF HOLDERS AND BENEFICIAL. OWNERS OF RECEIPTS 14 11 SECTION 3.1 Proofs, Certificates and Other Information 14 11 SECTION 3.2 Liability for Taxes and Other Charges 14 12 SECTION 3.3 Representations and Warranties on Deposit of Shares 15 12 SECTION 3.4 Compliance with Information Requests 15 13 ARTICLE IV THE DEPOSITED SECURITIES 15 SECURITIES. 13 SECTION 4.1 Cash Distributions 15 13 SECTION 4.2 Distribution in Shares 16 14 SECTION 4.3 Elective Distributions in Cash or Shares 17 14 SECTION 4.4 Distribution of Rights to Purchase Shares 17 15 SECTION 4.5 Distributions Other Than Cash, Shares or Rights to Purchase Shares 19 17 SECTION 4.6 Conversion of Foreign Currency 20 17 SECTION 4.7 Fixing of Record Date 20 18 SECTION 4.8 Voting of Deposited Securities 21 18 SECTION 4.9 Changes Affecting Deposited Securities 22 20 SECTION 4.10 Available Information 23 21 SECTION 4.11 Reports 23 21 SECTION 4.12 List of Holders 23 21 SECTION 4.13 Taxation; Withholding 24 21 SECTION 4.14 Affiliates etc 22 ARTICLE V. THE DEPOSITARY, THE CUSTODIAN AND THE COMPANY 25 23 SECTION 5.1 Maintenance of Office and Transfer Books by the Xxxxxxxxx Rxxxxxxxx 00 SECTION 5.2 Exoneration 25 23 SECTION 5.3 Standard of Care 26 24 SECTION 5.4 Resignation and Removal of the Depositary; Appointment of Successor Depositary 27 25 SECTION 5.5 The Custodian 28 26 SECTION 5.6 Notices and Reports 28 26 SECTION 5.7 Issuance of Additional Shares, ADSs etc. 29 27 SECTION 5.8 Indemnification 30 28 SECTION 5.9 Fees and Charges of Depositary 31 29 SECTION 5.10 Restricted Securities Owners/Ownership Restrictions 32 30 ARTICLE VI. AMENDMENT AND TERMINATION 33 31 SECTION 6.1 Amendment/Supplement 33 31 SECTION 6.2 Termination 34 32 ARTICLE VII. MISCELLANEOUS 35 33 SECTION 7.1 Counterparts 35 33 SECTION 7.2 No Third-Party Beneficiaries 35 33 SECTION 7.3 Severability 35 33 SECTION 7.4 Holders and Beneficial Owners as Parties; Binding Effect 35 33 SECTION 7.5 Notices 35 33 SECTION 7.6 Governing Law and Jurisdiction 36 34 SECTION 7.7 Assignment 38 36 SECTION 7.8 Agents 38 36 SECTION 7.9 Exclusivity 38 36 SECTION 7.10 Compliance with U.S. Securities Laws 38 36 SECTION 7.11 Titles 36 EXHIBIT A 38 EXHIBIT A A-1 EXHIBIT B B-147

CERTAIN OBLIGATIONS OF HOLDERS AND BENEFICIAL. OWNERS OF RECEIPTS 14 11 SECTION 3.1 Proofs, Certificates and Other Information 14 11 SECTION 3.2 Liability for Taxes and Other Charges 14 12 SECTION 3.3 Representations and Warranties on Deposit of Shares 15 13 SECTION 3.4 Compliance with Information Requests 15 13 ARTICLE IV THE DEPOSITED SECURITIES 15 SECURITIES. 14 SECTION 4.1 Cash Distributions 15 14 SECTION 4.2 Distribution in Shares 16 14 SECTION 4.3 Elective Distributions in Cash or Shares 17 15 SECTION 4.4 Distribution of Rights to Purchase Shares 17 16 SECTION 4.5 Distributions Other Than Cash, Shares or Rights to Purchase Shares 19 17 SECTION 4.6 Conversion of Foreign Currency 20 18 SECTION 4.7 Fixing of Record Date 20 19 SECTION 4.8 Voting of Deposited Securities 21 19 SECTION 4.9 Changes Affecting Deposited Securities 22 21 SECTION 4.10 Available Information 23 21 SECTION 4.11 Reports 23 21 SECTION 4.12 List of Holders 23 22 SECTION 4.13 Taxation; Withholding 24 22 SECTION 4.14 Affiliates etc 23 ARTICLE V. THE DEPOSITARY, THE CUSTODIAN AND THE COMPANY 25 23 SECTION 5.1 Maintenance of Office and Transfer Books by the Xxxxxxxxx 00 SECTION 5.2 Exoneration 25 24 SECTION 5.3 Standard of Care 26 25 SECTION 5.4 Resignation and Removal of the Depositary; Appointment of Successor Depositary 27 26 SECTION 5.5 The Custodian 28 27 SECTION 5.6 Notices and Reports 28 27 SECTION 5.7 Issuance of Additional Shares, ADSs etc. 29 28 SECTION 5.8 Indemnification 30 29 SECTION 5.9 Fees and Charges of Depositary 31 30 SECTION 5.10 Restricted Securities Owners/Ownership Restrictions 32 31 ARTICLE VI. AMENDMENT AND TERMINATION 33 32 SECTION 6.1 Amendment/Supplement 33 32 SECTION 6.2 Termination 34 32 ARTICLE VII. MISCELLANEOUS 35 34 SECTION 7.1 Counterparts 35 34 SECTION 7.2 No Third-Party Beneficiaries 35 34 SECTION 7.3 Severability 35 34 SECTION 7.4 Holders and Beneficial Owners as Parties; Binding Effect 35 34 SECTION 7.5 Notices 35 34 SECTION 7.6 Governing Law and Jurisdiction 36 35 SECTION 7.7 Assignment 38 37 SECTION 7.8 Agents 38 37 SECTION 7.9 Exclusivity 38 37 SECTION 7.10 Compliance with U.S. Securities Laws 38 37 SECTION 7.11 Titles 38 37 EXHIBIT A A-1 39 EXHIBIT B B-148

CERTAIN OBLIGATIONS OF HOLDERS AND BENEFICIAL. OWNERS OF RECEIPTS 14 12 SECTION 3.1 Proofs, Certificates and Other Information 14 12 SECTION 3.2 Liability for Taxes and Other Charges 14 13 SECTION 3.3 Representations and Warranties on Deposit of Shares 15 13 SECTION 3.4 Compliance with Information Requests 15 13 ARTICLE IV THE DEPOSITED SECURITIES 15 SECURITIES. 14 SECTION 4.1 Cash Distributions 15 14 SECTION 4.2 Distribution in Shares 16 14 SECTION 4.3 Elective Distributions in Cash or Shares 17 15 SECTION 4.4 Distribution of Rights to Purchase Shares 17 15 SECTION 4.5 Distributions Other Than Cash, Shares or Rights to Purchase Shares 19 17 SECTION 4.6 Conversion of Foreign Currency 20 18 SECTION 4.7 Fixing of Record Date 20 19 SECTION 4.8 Voting of Deposited Securities 21 19 SECTION 4.9 Changes Affecting Deposited Securities 22 21 SECTION 4.10 Available Information 23 21 SECTION 4.11 Reports 23 21 SECTION 4.12 List of Holders 23 22 SECTION 4.13 Taxation; Withholding 24 22 SECTION 4.14 Affiliates etc. 23 ARTICLE V. THE DEPOSITARY, THE CUSTODIAN AND THE COMPANY 25 23 SECTION 5.1 Maintenance of Office and Transfer Books by the Xxxxxxxxx 00 SECTION 5.2 Exoneration 25 24 SECTION 5.3 Standard of Care 26 25 SECTION 5.4 Resignation and Removal of the Depositary; Appointment of Successor Depositary 27 26 SECTION 5.5 The Custodian 28 27 SECTION 5.6 Notices and Reports 28 27 SECTION 5.7 Issuance of Additional Shares, ADSs etc. 29 28 SECTION 5.8 Indemnification 30 29 SECTION 5.9 Fees and Charges of Depositary 31 30 SECTION 5.10 Restricted Securities Owners/Ownership Restrictions 32 31 ARTICLE VI. AMENDMENT AND TERMINATION 33 32 SECTION 6.1 Amendment/Supplement 33 32 SECTION 6.2 Termination 34 33 ARTICLE VII. MISCELLANEOUS 35 34 SECTION 7.1 Counterparts 35 34 SECTION 7.2 No Third-Party Beneficiaries 35 34 SECTION 7.3 Severability 35 34 SECTION 7.4 Holders and Beneficial Owners as Parties; Binding Effect 35 34 SECTION 7.5 Notices 35 34 SECTION 7.6 Governing Law and Jurisdiction 36 35 SECTION 7.7 Assignment 38 37 SECTION 7.8 Agents 38 37 SECTION 7.9 Exclusivity 38 37 SECTION 7.10 Compliance with U.S. Securities Laws 38 37 SECTION 7.11 Titles 38 37 EXHIBIT A A-1 39 EXHIBIT B B-148

CERTAIN OBLIGATIONS OF HOLDERS AND BENEFICIAL. OWNERS OF RECEIPTS 14 11 SECTION 3.1 Proofs, Certificates and Other Information 14 11 SECTION 3.2 Liability for Taxes and Other Charges 14 12 SECTION 3.3 Representations and Warranties on Deposit of Shares 15 13 SECTION 3.4 Compliance with Information Requests 15 13 ARTICLE IV THE DEPOSITED SECURITIES 15 SECURITIES. 14 SECTION 4.1 Cash Distributions 15 14 SECTION 4.2 Distribution in Shares 16 14 SECTION 4.3 Elective Distributions in Cash or Shares 17 15 SECTION 4.4 Distribution of Rights to Purchase Shares 17 15 SECTION 4.5 Distributions Other Than Cash, Shares or Rights to Purchase Shares 19 17 SECTION 4.6 Conversion of Foreign Currency 20 18 SECTION 4.7 Fixing of Record Date 20 18 SECTION 4.8 Voting of Deposited Securities 21 19 SECTION 4.9 Changes Affecting Deposited Securities 22 21 SECTION 4.10 Available Information 23 21 SECTION 4.11 Reports 23 21 SECTION 4.12 List of Holders 23 22 SECTION 4.13 Taxation; Withholding 24 22 SECTION 4.14 Affiliates etc 23 ARTICLE V. THE DEPOSITARY, THE CUSTODIAN AND THE COMPANY 25 23 SECTION 5.1 Maintenance of Office and Transfer Books by the Xxxxxxxxx 00 Registrar 23 SECTION 5.2 Exoneration 25 24 SECTION 5.3 Standard of Care 26 25 SECTION 5.4 Resignation and Removal of the Depositary; Appointment of Successor Depositary 27 26 SECTION 5.5 The Custodian 28 27 SECTION 5.6 Notices and Reports 28 27 SECTION 5.7 Issuance of Additional Shares, ADSs etc. 29 28 SECTION 5.8 Indemnification 30 29 SECTION 5.9 Fees and Charges of Depositary 31 30 SECTION 5.10 Restricted Securities Owners/Ownership Restrictions 32 31 ARTICLE VI. AMENDMENT AND TERMINATION 33 31 SECTION 6.1 Amendment/Supplement 33 31 SECTION 6.2 Termination 34 32 ARTICLE VII. MISCELLANEOUS 35 33 SECTION 7.1 Counterparts 35 33 SECTION 7.2 No Third-Third Party Beneficiaries 35 33 SECTION 7.3 Severability 35 34 SECTION 7.4 Holders and Beneficial Owners as Parties; Binding Effect 35 34 SECTION 7.5 Notices 35 34 SECTION 7.6 Governing Law and Jurisdiction 36 35 SECTION 7.7 Assignment 38 36 SECTION 7.8 Agents 38 36 SECTION 7.9 Exclusivity 38 37 SECTION 7.10 Compliance with U.S. Securities Laws 38 37 SECTION 7.11 Titles 38 37 EXHIBIT A A-1 39 EXHIBIT B B-148