Contrast mechanisms associated with Neuromelanin-MRI

Contrast mechanisms associated with Neuromelanin-MRI

▇▇▇▇▇ Trujillo1,2, ▇▇▇▇ Summers1, ▇▇▇▇▇▇▇▇ Ferrari3, ▇▇▇▇▇ ▇. Zucca3, Michela Sturini4, Luca Mainardi2, ▇▇▇▇▇▇ Cerutti2, Alex K Smith5,6, Seth A Smith5,6,7, ▇▇▇▇▇ Zecca3, Antonella Costa1

1 Department of Neuroradiology, Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico, Milan, MI, Italy

2 Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, MI, Italy

3 Institute of Biomedical Technologies, National Research Council of Italy, Segrate, MI, Italy

4 Department of Chemistry, University of Pavia, Pavia, PV, Italy

5 Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA

6 Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA

7 Department of Radiology and Radiological Sciences, ▇▇▇▇▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇, ▇▇▇▇▇▇▇▇▇, ▇▇, ▇▇▇

Full postal and email address of the corresponding author:

▇▇▇▇▇ ▇▇▇▇▇▇▇▇

Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico Department of Neuroradiology

▇▇▇ ▇. ▇▇▇▇▇▇ ▇▇ ▇▇▇▇▇, ▇▇▇▇▇, ▇▇, ▇▇▇▇▇

Email: ▇▇▇▇▇.▇▇▇▇▇▇▇▇@▇▇▇▇▇▇.▇▇

Abbreviations: BSA = bovine serum albumin; DS = direct saturation; LC = locus coeruleus; MT =

PDJQHWL]DWLRQ WUDQVIHU 10 1HXURPHODQLQ 3' 3

煵愀渀琀椀琀愀琀椀癥⁍吀㬀⁒䘀‽⁲愀搀椀潦爀攀焀甀攀湣礀㬀 匀一‽⁓甀 扳琀愀渀琀椀愀⁎椀最爀愀㬀⁔匀䔠