Examples of Week 4 in a sentence
All analyses will be presented by treatment group and dosing regimen (AM dosing, Week 1 – Week 4; PM dosing, Week 5 – Week 8).
IOP change from diurnal baseline [this is the time-matched subtraction of each of the 4 IOP timepoints of the circadian curve post randomization from the pre-randomization circadian curve] calculated at the Week 4 and Week 8 visit each of the doses/combinations tested.
All efficacy data will be presented by randomized treatment group and dosing regimen (AM dosing, Week 1 – Week 4 when randomized treatment is used during AM; PM dosing, Week 5 – Week 8 when randomized treatment is used during PM).
Daily IOP (average of the 4 serial IOPs taken during a dosing interval) calculated at the Week 4 visit and the Week 8 visit.
Daily IOP-change from diurnal baseline (average of the 4 diurnal changes from baseline calculated during a dosing interval) calculated at the Week 4 visit and the Week 8 visit.
IOP change from study baseline [this calculates the change in IOP from the 8AM Day 1 baseline IOP] calculated at the end of the Week 4 and Week 8 visit for each of the doses/combinations tested.
Daily IOP-change from study baseline (average of the 4 changes from study baseline calculated during a dosing interval) calculated at the Week 4 visit and the Week 8 visit.
The four IOP measurements from Day -1 are used as the diurnal baseline for the analyses at both Week 4 and Week 8.
Mean IOP at 8AM, 10AM, 12PM, and 4PM for the subject's ‘study' eye calculated at the Week 4 and Week 8 visit for each of the doses/combinations tested.
The primary efficacy endpoint is the daily IOP-change from diurnal baseline (average of the 4 diurnal changes from baseline calculated during a dosing interval) calculated at the Week 4 (after 4 weeks of AM dosing regimen) visit and the Week 8 visit (after 4 weeks of PM dosing regimen).