Treg definition

Treg means regulatory T cells that are a subpopulation of T cells which negatively regulate the immune system, maintain tolerance to self-antigens, suppress immune system in cancers and/or abrogate autoimmune disease. The Parties understand and agree that “Treg Cells” includes both natural Treg Cells (nTreg) and inducible Treg Cells (iTreg).
View Source
Treg. ELECSU::J~'3WIT8:-" CT~:
View Source
Treg shall have the meaning set forth in the first paragraph of this Agreement.
View Source

Examples of Treg in a sentence

  • The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis.

  • The available data up to 16 weeks after initiation of treatment suggest a decrease of these biomarker levels, which is consistent with the observed enhancement of Treg function.

  • Patients in the study received investigational treatment for 48 consecutive weeks and were evaluated for safety and tolerability, Treg function, serum biomarkers of oxidative stress and inflammation, and clinical functioning as measured by the ALSFRS-R scale.

  • Treg suppressive function at 24 weeks (79.9±9.6) and 48 weeks (89.5±4.1) were significantly higher compared to baseline (62.1±8.1) (p<0.01), suggesting enhanced and durable Treg suppressive function over the course of treatment.

  • Treg suppressive function, expressed as percentage of inhibition of proinflammatory T cell proliferation, showed a statistically significant increase over the course of the treatment period and was significantly reduced at the end of the 8-week washout post-treatment period.

  • In contrast, Treg suppressive function (mean ±SD) was significantly decreased at the end of the 8-week washout period compared to end-of-treatment at week 48 (70.3±8.1 vs.

  • Thus far, microbiota elicited Treg populations have shown to regulate Type 2 immunity90,91.

  • Over the past several years, in vitro evidence has emerged demonstrating that intestinal APCs are endowed with the capacity to induce Treg or Th17 cell responses, depending upon the type of APC and the context of stimulation (13-15).

  • Differentiation into the most severe form, lepromatous leprosy, is characterized by a humoral Th2 and T regulatory (Treg) immune response, characterized by increased IL-4 and IL-10, antibody production, absence of granulomas, and failure to inhibit M.

  • The fact that Treg cells did not exceed the baseline levels of naïve control mice, combined with the lack of any activity markers, suggests that there is no active suppression by Treg cells during the allergen challenge phase.