TNF definition

TNF means the Trade Negotiating Forum;
TNF has the meaning set forth in the preamble hereto. ---
TNF means the Trade Negotiating Forum.

Examples of TNF in a sentence

  • The mechanism of action of etanercept is thought to be its competitive inhibition of TNF binding to cell surface TNFR, preventing TNF-mediated cellular responses by rendering TNF biologically inactive.

  • In future years the farmers took no action to prepare for the season while they waited for government to come up with the inputs.

  • Etanercept may also modulate biologic responses controlled by additional downstream molecules (e.g., cytokines, adhesion molecules, or proteinases) that are induced or regulated by TNF.

  • Etanercept is a competitive inhibitor of TNF binding to its cell surface receptors, and thereby inhibits the biological activity of TNF.

  • A higher rate of serious infections has also been observed in patients with RA treated with rituximab who received subsequent treatment with a TNF blocker.

  • The majority of reported TNF blocker cases have occurred in patients with Crohn's disease or ulcerative colitis and the majority were in adolescent and young adult males.

  • TNF and lymphotoxin exist predominantly as homotrimers, with their biological activity dependent on cross-linking of cell surface TNFRs. Dimeric soluble receptors, such as etanercept, possess a higher affinity for TNF than monomeric receptors and are considerably more potent competitive inhibitors of TNF binding to its cellular receptors.

  • Neither carcinogenicity studies, nor a standard assessment of fertility and postnatal toxicity, were performed with adalimumab due to the lack of appropriate models for an antibody with limited cross-reactivity to rodent TNF and to the development of neutralising antibodies in rodents.

  • Mechanism of actionMuch of the joint pathology in rheumatoid arthritis and ankylosing spondylitis and skin pathology in plaque psoriasis is mediated by pro-inflammatory molecules that are linked in a network controlled by TNF.

  • Adalimumab also modulates biological responses that are induced or regulated by TNF, including changes in the levels of adhesion molecules responsible for leukocyte migration (ELAM-1, VCAM-1, and ICAM-1 with an IC50 of 0.1-0.2 nM).


More Definitions of TNF

TNF means tumor necrosis factor, which is part of the body’s response to inflammation.
TNF means human Tumor Necrosis Factor.
TNF. (Technically not Feasible) means the area where BSNL is not able to provide new wireline (Copper /FTTH) Broadband connection of required download speed.
TNF means any protein, whether or not glycosylated, with the amino acid sequence set forth in Figure 4 on page 152 of the article "Molecular Cloning of the Complementary DNA for Human Tumor Necrosis Factor," by Wang, ET AL., SCIENCE, Vol. 228 (April 12, 1985), and any fragment or amino terminal or carboxy terminal variant of such protein, and any protein Homologous to any such protein, variant or fragment, and any polypeptide construct derived from and including a portion of the amino acid sequence above that is developed in the course of work on such sequence, provided that such protein, variant, fragment, Homologous protein or construct has cytostatic or cytotoxic activity. Chemical modifications of any such protein, fragment, variant, Homologous protein and construct are specifically included in the definition, provided they have cytostatic or cytotoxic activity. For the purpose of this definition, a substance that has "cytostatic or cytotoxic activity" shall mean a substance that (a) has IN VITRO cytostatic or cytotoxic activity against at least four discrete human malignant tumor cell lines, (b) causes IN VIVO necrosis of subcutaneous methylcholanthrene-induced murine fibrosarcoma upon systemic or intratumoral administration, and (c) has significantly less IN VITRO cytostatic and/or cytotoxic activity against normal cell lines than against malignant tumor cell lines.
TNF is the number of hours the Equipment or any component of the Equipment is not functional during the quarter (the hours calculated will only include those hours that the Equipment would typically be in use). If any portion of the total functionality of the Equipment is unavailable for operational use, the Equipment will be considered down. Downtime scheduled for preventive maintenance or any other scheduled event, including those for the convenience of Member, will not be included in the downtime calculation. Member will calculate uptime after each calendar quarter. If uptime is less than [**]%, any lost revenue suffered by the Member for downtime beyond the allowable [**]% during the quarter will be paid by Supplier to the Member. Lost revenue will be calculated by multiplying the number of procedures that would have been performed or the number of times the Equipment would have been used during any downtime times the Member's current charge rate per procedure or per use. The Member will give written notice to Supplier of its failure to meet the uptime requirement and the amount of lost revenues, and Supplier will pay such amount to the Member within thirty (30) days after receipt of the notice. In addition, Supplier will extend the Warranty Period or the service agreement without charge by one week for every hour the Equipment or component thereof is not operational beyond the allowable [**]%.

Related to TNF

  • HBV means hepatitis B virus.

  • Receptor means enclosed spaces, conduits, protected groundwater sources, drinking and non-drinking water wells, surface water bodies, and public water systems which when impacted by chemicals of concern may result in exposure to humans and aquatic life, explosive conditions or other adverse effects on health, safety and the environment as specified in these rules.

  • Opioid antagonist means a drug that binds to opioid

  • Vaccine means a specially prepared antigen which, upon administration to a person, will result in immunity and, specifically for the purposes of this rule, shall mean influenza and pneumococcal vaccines.

  • DNA profile means a letter or number code which represents a set of identification characteristics of the non-coding part of an analysed human DNA sample, i.e. the particular molecular structure at the various DNA locations (loci);

  • Dyslexia means a disorder of constitutional origin manifested by a difficulty in learning to read, write, or spell, despite conventional instruction, adequate intelligence, and sociocultural opportunity.

  • Biomarker means a parameter or characteristic in a patient or Patient Sample, the measurement of which is useful (a) for purposes of selecting appropriate therapies or patient populations or monitoring disease susceptibility, severity or state, or monitoring therapies for such patient and/or (b) for predicting the outcome of a particular treatment of such patient.

  • Vector means a carrier that is capable of transmitting a pathogen from one organism to another including, but not limited to, flies and other insects, rodents, birds, and vermin.

  • coronavirus means severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2);

  • Medical cannabis card means the same as that term is defined in Section 26-61a-102.

  • Biological diversity means the variability among living organisms from all sources including, inter alia, terrestrial, marine and other aquatic ecosystems and the ecological complexes of which they are part; this includes diversity within species, between species and of ecosystems.

  • Embryo or "fetus" means the developing human organism from conception until time of birth.

  • Cell means a single encased electrochemical unit containing one positive and one negative electrode which exhibits a voltage differential across its two terminals.

  • TLR means the NERC Transmission Loading Relief Procedures used in the Eastern Interconnection as specified in NERC Operating Policies.

  • Step therapy means a protocol or

  • Clinical categories means the groups into which hospital treatments are categorised by type, e.g., brain and nervous system, kidney and bladder, and digestive system. At the time of writing there were 38 categories in the Medicare clinical categories system.

  • Target Population means persons with low incomes who have one or more disabilities, including mental illness, HIV or AIDS, substance abuse, or other chronic health condition, or individuals eligible for services provided pursuant to the Lanterman Developmental Disabilities Services Act (Division 4.5 (commencing with Section 4500) of the Welfare and Institutions Code) and may include, among other populations, adults, emancipated minors, families with children, elderly persons, young adults aging out of the foster care system, individuals exiting from institutional settings, veterans, and homeless people.

  • scientific research means any activity in the field of natural or applied science for the extension of knowledge;

  • Pathogen means an organism that is capable of producing an infection or disease in a susceptible host.

  • Cannabinoid edible means food or potable liquid into which a cannabinoid concentrate, cannabinoid extract or dried marijuana leaves or flowers have been incorporated.

  • Opioid means a drug that produces an agonist effect on opioid receptors and is indicated or used for the treatment of pain.

  • Alpha means Alpha Natural Resources, Inc., a Delaware corporation.

  • Cannabinoid means any of the chemical compounds that are the active constituents of marijuana.

  • UMDAP means the SDHCS’s Uniform Method of Determining Ability to Pay (included as part of County’s Client Registration Payor Financial Information Insurance Authorization Form);

  • STEM means science, technology, engineering, and mathematics.

  • Embryo/fetus means the developing human organism from conception until the time of birth.