TIGIT definition

TIGIT means T cell immunoreceptor with Ig and ITIM domains; also known as ▇▇▇▇▇, ▇▇▇▇▇ and WUCAM and having the sequence and activity as described in UnitProt ID Q495A1, NCBI Reference Sequence: NP_776160.2, as well as splice variants and allotypic variants of the TIGIT protein with a sequence identity of at least [***]% of sequences referenced herein.

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TIGIT means that Hippo Umbrella Target (as defined in the Celgene Collaboration Agreement) known as TIGIT and designated as a target by Celgene effective December 22, 2015.

TIGIT means the T-cell immunoreceptor with immunoglobulin and ITIM domains.

Examples of TIGIT in a sentence

• Incyte agrees that beginning on the Amendment Date, nothing in the Original Agreement shall prohibit Agenus from Developing, Manufacturing, Commercializing or otherwise exploiting Antibodies that Interact with TIGIT without limitation, within and outside the Field, independently or with Third Parties, under the Patent Rights and Know-How Controlled by Agenus.

• In addition, COM902, Compugen’s antibody targeting TIGIT, is in a Phase 1 clinical study.

• It is the intent of the Company for the assignment of an amount in cash equal to the TIGIT Payment Amounts, when, as and if such TIGIT Payment Amounts are actually received by the Company pursuant to Section 2.1(c) to be complete and irrevocable.

• Preclinical data for COM701 suggest that PVRIG may be a dominant checkpoint in diverse patient populations with tumors that express elevated PVRL2 as compared to expression of the TIGIT ligand PVR.

• Compugen also has a clinical stage partnered program, rilvegostomig (previously AZD2936), a PD-1/TIGIT bispecific antibody where the TIGIT component is derived from Compugen’s clinical stage anti-TIGIT antibody, COM902, in Phase 3 development by AstraZeneca through a license agreement for the development of bispecific and multispecific antibodies.

• The Company shall take no action for the principal purpose of (i) reducing the amount of any TIGIT Payment Amounts payable under this Agreement or (ii) restricting the Company’s ability to pay any of the TIGIT Payment Amounts hereunder.

• If the audit reveals an overpayment, the Company shall be entitled to withhold such amount from future payments of TIGIT Payment Amounts.

• In these tumors the blockade of both TIGIT and PVRIG may be required to sufficiently stimulate an anti-tumor immune response, with or without additional PD-1 pathway blockade.

• Without limiting the foregoing, each Party acknowledges and agrees that all Antibodies that Interact solely with [**] or TIGIT and which were discovered under the Research Plan or delivered to the Returning Party in the performance of the Program prior to the Amendment Date, including fragments, derivatives and modifications thereof, shall, as of the Amendment Date, no longer constitute Licensed Antibodies.

• The milestone payments to be paid by the Project Party to the Returning Party for Royalty-Bearing Products set forth in Section 7.5(b) of the Original Agreement shall apply to TIGIT Products and [**] Products without modification[**].

More Definitions of TIGIT

TIGIT means that Hippo Designated Target (as defined in the Celgene Collaboration Agreement) known as TIGIT, which was designated as a target by Celgene effective December 23, 2015.

TIGIT means the T cell immunoreceptor with Ig and ITIM domains that is otherwise known as WUCAM and Vstm3. [********] = Portions of this exhibit have been omitted pursuant to a confidential treatment request. An unredacted version of this exhibit has been filed separately with the Commission.