Specifically Binds definition

Specifically Binds means binding with a dissociation constant (Kd) of at least 10-6M.
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Specifically Binds means, in the case of a SMIP or other protein, the binding of such SMIP or other protein to a Target (or a portion thereof) above the level of background binding and wherein such SMIP or other protein is designed or being developed to exert its biological effect through binding to such Target (or such portion thereof).
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Specifically Binds refers to those antibodies that have a minimum affinity (KD value) of [******] (as measured by standard techniques such as the BIAcore) toward a specified antigen and do not bind to related isozymes, proteins or antigens with an affinity of better than 1 uM. Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential Investment under Rule 24b-2 under the Securities Exchange Act of 1934.
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Examples of Specifically Binds in a sentence

  • In the event that Kolltan determines, prior to or at the earlier of (a) completion of preclinical toxicology, including data analysis, with respect to an Antibody that Specifically Binds the Target, and (b) [**] from the Effective Date, that Kolltan no longer wishes to pursue the Target, Kolltan may elect in writing to Spirogen to pursue the Replacement Target.

  • RESULTS KRP2 Specifically Binds and Inhibits CDKA;1 and Not CDKB1;1Previously, the interaction of KRP proteins with the archetypical A-type CDKA;1 but not with the B-type CDKB1;1 has been dem- onstrated by yeast two-hybrid analysis (Lui et al., 2000; De Veylder et al., 2001; Zhou et al., 2002).

  • References herein to any Product “directed to” or “with respect to” a particular Target mean that such Product contains an ADC comprising an Antibody that Specifically Binds such Target.

  • References herein to any ADC “directed to” or “with respect to” a particular Target mean that such ADC comprises an Antibody that Specifically Binds such Target.

  • LmPC Specifically Binds and Is Inhibited by c-di-AMP.‌(A) Binding titration of c-di-AMP and LmPC using32P-c-di-AMP.(B) Enzymatic activity of LmPC in the presence of Acetyl-CoA (100 mM), varied pyruvate, and c-di- AMP concentrations as indicated.(C) Rate constants of pyruvate turnover in the presence of c-di-AMP.(D) Enzymatic activity of LmPC in the presence of pyruvate (20 mM), varied Acetyl-CoA (allosteric activator) and c-di-AMP concentrations as indi- cated.

  • In such instance, Kolltan shall no longer be licensed under this Agreement with respect to an ADC Drug Reagent having an Antibody that Specifically Binds KIT but thereafter shall be licensed under this Agreement with respect to an ADC Drug Reagent that has an Antibody that Specifically Binds the Replacement Target, and Kolltan agrees, in such circumstance, not to pursue work on an ADC Drug Reagent having an Antibody that Specifically Binds KIT utilizing materials provided by Spirogen.

  • Employees are not permitted to use Selectemp or our customers computer systems to access inappropriate internet sites such as (but not limited to), gambling sites, pornography or any sexually related sites, dating or matchmaking sites, personal e-mail sites, etc.

  • RESULTS The SHARPIN UBL Domain Specifically Binds to the UBA Domain of HOIP ~ ~ To clarify the interaction mechanism between HOIP and SHARPIN, we first used the GFP-tagged SHARPIN UBL domain (residues 206–309) (hereafter referred to as SHARPINUBL) to map its binding region in HOIP by co-immunoprecipitation (coIP) assay.

  • During the Term, Sangamo shall not work independently of this Agreement for itself or any Affiliate or Third Party (including the grant of any license to any Third Party) with respect to the development or commercialization, for therapeutic or diagnostic purposes, of (i) any product that can be used clinically or diagnostically to (A) [***], or (B) [***], other than through the [***], (ii) any Shire ZF Product or (iii) any ZF Compound that Specifically Binds a Shire Target.

  • HgII Ion Specifically Binds with T:T Mismatched Base Pair in Duplex DNA.


More Definitions of Specifically Binds

Specifically Binds means [***].
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Specifically Binds means binding with a dissociation constant (Kd) of at least [**].
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Related to Specifically Binds

  • Technically Feasible refers solely to technical or operational concerns, rather than economic, space, or site considerations.

  • Categorically needy means, insofar as funds are available for the category, a person who

  • Non-surgically implanted prostheses means a replacement body part not surgically implanted.

  • Biologically-based mental illness means schizophrenia, schizoaffective disorder, major depressive disorder, bipolar disorder, paranoia and other psychotic disorders, obsessive-compulsive disorder, and panic disorder, as these terms are defined in the most recent edition of the diagnostic and statistical manual of mental disorders published by the American Psychiatric Association.

  • Technically exhaustive means an inspection involving the use of measurements, instruments, testing, calculations, and other means to develop scientific or engineering findings, conclusions, and recommendations.

  • Contractor Commercially Sensitive Information means the information listed in the Contractor Commercial Sensitive Information Annex to the Contract being information notified by the Contractor to the Authority which is acknowledged by the Authority as being commercially sensitive information.

  • Collaboration Know-How means all Know-How conceived, discovered, developed or otherwise made by or on behalf of a particular Party or any of its Affiliates or permitted subcontractors of any of the foregoing (solely or jointly by or on behalf of a particular Party or any of its Affiliates or permitted subcontractors of any of the foregoing) in the course of [***].

  • Joint Know-How has the meaning set forth in Section 8.1.2.

  • Additional SDU Study means a deliverability study that a Developer may elect to pursue as that term is defined in OATT Section 25 (OATT Attachment S). For purposes of Section 23.4.5 of this Attachment H, “Affiliated Entity” shall mean, with respect to a person or Entity:

  • Commercially Sensitive Information means the Information (i) listed in the Commercially Sensitive Information Schedule; or (ii) notified to the Authority in writing (prior to the commencement of this Contract) which has been clearly marked as Commercially Sensitive Information comprised of information:

  • Sexually Explicit Material means any depiction of actual or simulated sexually explicit conduct.

  • Therapeutically equivalent drug products means drug products that contain the same active

  • License Type means the type of license granted be it a perpetual license or subscription license for a specified duration, such information being as specified in the Notification Form.

  • Specific Terms and Conditions means the specific terms and conditions as described in section 6.1 (and, in relation to an Agreement between Envestra and a Network User, means the Specific Terms and Conditions which form part of that Agreement).

  • Massive Multiauthor Collaboration Site (or “MMC Site”) means any World Wide Web server that publishes copyrightable works and also provides prominent facilities for anybody to edit those works. A public wiki that anybody can edit is an example of such a server. A “Massive Multiauthor Collaboration” (or “MMC”) contained in the site means any set of copyrightable works thus published on the MMC site.

  • Program Materials means the documents and information provided by the Program Administrator specifying the qualifying EEMs, technology requirements, costs and other Program requirements, which include, without limitation, program guidelines and requirements, application forms and approval letters.

  • Product Know-How means all the know how, trade secrets, expertise, inventions, discoveries, technical information and other unpatented information related solely and specifically to the Product, that is owned or controlled by Seller or its Affiliates and used in the Territory, including, but not limited to, all information presently used by the Seller to make, have made, use or sell the Product.

  • Initial Indication means the use of a Product for the treatment of opioid addiction.

  • Research Use shall have the meaning given in Section 2.2.2 of this Agreement.

  • Commercially Sensitive Information Schedule means the Schedule containing a list of the Commercially Sensitive Information.

  • Project specific information means such part of the Instructions to Consultants used to reflect specific project and assignment conditions.

  • Licensed Know-How means all Know-How that (a) is Controlled by Pfizer or any of its Affiliates as of the effective date of the Pfizer-MPP Agreement, (b) directly relates to the use of the Compound, Product or Licensed Product in the Field, and (c) is not in the public domain or otherwise generally known. For the avoidance of doubt, (i) Licensed Know-How shall not include any Know-How to the extent solely and directly related to any other Pfizer compound or to the extent related to the use of the Compound, Product or Licensed Product outside the Field and (ii) Licensed Know-How includes only that Know-How, designated by Pfizer in its sole discretion, necessary for the manufacture, registration and commercialization of the Compound and/or Licensed Product for use in the Field. For the avoidance of doubt, Licensed Know-How excludes any Know-How related to ritonavir that has been (either as of the Effective Date or at any time during the term of this Agreement) in-licensed by Pfizer from any Third Party.

  • Specially Written Software means any software created by the Contractor (or by a third party on behalf of the Contractor) specifically for the purposes of this Contract.

  • Category 4 Data is data that is confidential and requires special handling due to statutes or regulations that require especially strict protection of the data and from which especially serious consequences may arise in the event of any compromise of such data. Data classified as Category 4 includes but is not limited to data protected by: the Health Insurance Portability and Accountability Act (HIPAA), Pub. L. 104-191 as amended by the Health Information Technology for Economic and Clinical Health Act of 2009 (HITECH), 45 CFR Parts 160 and 164; the Family Educational Rights and Privacy Act (FERPA), 20 U.S.C. §1232g; 34 CFR Part 99; Internal Revenue Service Publication 1075 (xxxxx://xxx.xxx.xxx/pub/irs-pdf/p1075.pdf); Substance Abuse and Mental Health Services Administration regulations on Confidentiality of Alcohol and Drug Abuse Patient Records, 42 CFR Part 2; and/or Criminal Justice Information Services, 28 CFR Part 20.

  • Victim or target of Nazi persecution means any individual persecuted or targeted for persecution by

  • Additional Indication means any indication other than the Initial Indication.