PKA definition

PKA means Pensionskassernes Administration A/S, a Danish Pension fund;
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Examples of PKA in a sentence

  • According to a single point kinase active site-directed competition binding KinomescanTM assay, in which the capability of the probes to inhibit a panel of 111 human kinases was examined, both probes 49 and 50 have a preference to inhibit Ser/Thr kinases including PKA and AKT1.

  • Specific consensus sites were identified as targets of PKA phosphorylation; it was found that mutation of these sites either to alanine (to eliminate the side chain) (Cheng et al., 1991) or to aspartic acid (to mimic phosphorylation (Rich et al., 1993)) altered the dependence of the channel on cAMP or PKA.

  • Following this, both photocrosslinking probes were subjected to labeling experiments in which they showed to photocrosslink recombinant PKA and AKT1 efficiently and specifically upon UV activation.

  • The detection of phosphorylation of PKA substrates in the cell lysate containing activated MAPK cascade can be due to the fact that multiple serine/theronine kinases share the same target.

  • The effect of these 239 compounds on PKA, AKT1, AKT2 and FLT3 was evaluated using a TR-FRET kinase activity assay.

  • It was therefore concluded that CysNO induces vasodilation independently of the classical NO-sGC-cGMP pathway, with s-nitrosylation of PKA and/or PKG as possible mechanisms[200].

  • The inhibitory potency towards PKA, AKT1, AKT2 and FLT3 of the 102 newly synthesized isoquinolinesulfonamides together with 137 isoquinolinesulfonamides previously prepared1 are discussed in Chapter 4.

  • It had been suggested that Ser795 of CFTR can be phosphorylated by PKA [15], but this phosphorylation was not detected in vitro on the PamChip.

  • It is also noted that 4 out of the 7 peptides were reported to be phosphorylated by synthetic PKA on the same serine threonine kinase array, including Ser303/304 of NCF1, Ser15 of CGHB, Thr278 of VASP and Ser15 of PYGL [23].

  • These responses were decreased by PKG inhibition and to a greater degree, PKA inhibition.

Related to PKA

  • Panchayat means an institution (by whatever name called) of self-government constituted under article 243B, for the rural areas;

  • Tabarru ” means donation for the purpose of solidarity and cooperation among the Takaful Participants and to be used to help all Takaful Participants in times of misfortune. In the context of the Company, Tabarru’ will be allocated into the Participants’ Risk Fund.

  • Lacquer means a clear or opaque wood coating, including clear lacquer sanding sealers, formulated with cellulosic or synthetic resins to dry by evaporation without chemical reaction and to provide a solid, protective film.

  • SAMR means the State Administration for Market Regulation of the PRC or, with respect to the issuance of any business license or filing or registration to be effected by or with the State Administration for Market Regulation, any Governmental Authority which is similarly competent to issue such business license or accept such filing or registration under the Laws of the PRC.

  • LHSIA means the Local Health System Integration Act, 2006, and the regulations made under it, as it and they may be amended from time to time;