PI3K definition

PI3K means: (a) the gene encoding the [ * ] for a member of the [ * ] consisting of the following [ * ] known as [ * ], and [ * ]; (b) the protein encoded by such gene; and (c) all [ * ] and [ * ] thereof. For the purposes of this Termination Agreement the term “PI3K” refers to [ * ] only, and does not include [ * ].
PI3K means: (a) the gene encoding [ * ]; (b) the protein encoded by such gene and (c) all [ * ]. For the purposes of this Agreement the term “PI3K” refers to [ * ].
PI3K means Phosphatidylinositol 3-kinases, a family of enzymes that phosphorylate the 3 position hydroxyl group of the inositol ring of phosphatidylinositol. Class 1A kinases are composed of a p85 regulatory chain and a p110 catalytic chain, of which there are three (3) isoforms: PI3Kalpha, PI3Kbeta, PI3Kdelta. Class IB kinase is composed of a p101 regulatory chain and a p110 catalytic chain, of which there is one (1) isoform: PI3Kgamma.

Examples of PI3K in a sentence

  • Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly activate myeloid cell PI3K, a single convergent point promoting tumor inflammation and progression.

  • Targeting PI3K signalling in cancer: opportunities, challenges and limitations.

  • Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.

  • PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.

  • A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.

  • Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers.

  • Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis.

  • Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents.

  • PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D.

  • Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3K, a single convergent point promoting tumor inflammation and progression.


More Definitions of PI3K

PI3K means: (a) the gene encoding [ * ]; (b) the protein encoded by such gene; and (c) all [ * ]. For the purposes of this Agreement the term “PI3K” refers to [ * ]. [ * ] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

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