Physiological Factors definition
Physiological Factors. Additional review papers hypothesized similar multifactorial causes for SIDS, including a paper by Mage et al. which outlined a quadruple risk model for SIDS [51]. The model included “X-linked genetic susceptibility, respiratory infection, neurological prematurity, and physiological anemia of infancy and apnea” [51]. This model included the ideas of infant vulnerability, a critical developmental period, and outside stressors, but differed from previous triple risk hypotheses by incorporating genetic susceptibility. The authors used Centers for Disease Control and Prevention (CDC) data on live births and deaths from 1979-2005 to evaluate the applicability of their model. They concluded that the model explains the gender, age, and seasonal variations seen in the SIDS surveillance data. Infant susceptibilities, including apnea, respiratory infections, and neurological prematurity could also be connected to one another mathematically through use of the model. This theory has not been tested on additional data, however [51].