PH1 definition

PH1 means Primary Hyperoxaluria 1.
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PH1 means as defined in the preamble of this Agreement. Its organizational identification number issued by its state of formation is 637347.
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Examples of PH1 in a sentence

  • By reducing oxalate production, this approach is designed to prevent the complications of PH1.

  • PH1 is characterized by a genetic deficiency of the liver enzyme alanine:glyoxalate-aminotransferase (AGT), which is encoded by the AGXT gene.

  • DCR-PH1 is engineered to address the pathology of PH1 by targeting and destroying the messenger RNA (mRNA) produced by HAO1, a gene implicated in the pathogenesis of PH1.

  • About Primary Hyperoxaluria Type 1 (PH1) PH1 is a rare, inherited liver disorder that often results in severe damage to the kidneys.

  • In preclinical studies, DCR-PH1 has been shown to induce potent and long-term inhibition of HAO1 and to significantly reduce levels of urinary oxalate, while demonstrating long-term efficacy and tolerability in animal models of PH1.

  • Aside from having to endure frequent dialysis, PH1 patients with ESRD may experience a build-up of oxalate in the bone, skin, heart and retina, with concomitant debilitating complications.

  • While the true prevalence of primary hyperoxaluria is unknown, it is estimated to be one to three cases per one million people.1 Fifty percent of patients with PH1 reach ESRD by their mid-30s.2 Dicerna is developing DCR-PH1, which is in preclinical development, for the treatment of PH1.

  • Distributor shall report to Atossa any use or disclosure of PH1 not permitted by this Agreement, of which it becomes aware, such report to be made within two (2) business days of the Distributor becoming aware of such use or disclosure.

  • Distributor agrees to implement reasonable systems for the discovery and prompt reporting of any "breach " of "unsecured PH1" as those term s are defined by 45 C.F.R. § J 64.402 (hereinafter a "HIPAA Breach ").

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