NOAEL definition

NOAEL means the highest level of toxicant which results in no observable adverse effects to exposed test organisms.
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NOAEL means the highest level of toxicant which results in no observable adverse effects to exposed test organisms. (32) “n-octanol/water partition coefficient (Kow)” means the ratio of the octanol to water equilibrium concentrations of a compound.
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Examples of NOAEL in a sentence

  • The NOAEL is defined as the highest dose at which no adverse effects are observed, while the LOAEL is defined as the lowest dose at which adverse effects are observed.

  • An RfC, based upon significant increases in liver weights for male rats, was derived from the NOAEL.

  • The No Observed Adverse Effect Level (NOAEL) was 15, 25 and 25 µg/kg/day in rats in the 4-, 13, and 26-week studies, respectively, and 100, 50 and £ 10 µg/kg/day in monkeys in the 4-, 13- and 39-week studies, respectively.

  • Uncertainty factors, or safety factors, are applied to the NOAEL or LOAEL observed in animal studies or human epidemiological studies to establish reference doses (RfDs).

  • This threshold dose is usually estimated from the “No Observed Adverse Effect Level” (NOAEL) or the “Lowest Observed Adverse Effect Level” (LOAEL) determined from chronic (i.e., long-term) animal studies.

  • The RfC is based upon fetal toxicity in mice and is derived from the NOAEL.

  • Based upon pathological changes in the liver, kidneys, gastrointestinal mucosa, and hematopoietic tissues of male and female beagle dogs, an RfD was derived from the NOAEL.

  • The RfD was derived from the NOAEL and based upon) increased kidney weights in rats.

  • The oral RfD was derived from the NOAEL; which is based on liver effects in dogs.

  • The ND was derived from the NOAEL based upon liver lesions in rats.