NICD definition
Examples of NICD in a sentence
We devised two strategies to block Notch pathway activation; γ-secretase inhibitor treatment, preventing nuclear translocation of the NICD, and competing for receptor-ligand interactions through excess soluble ligand, Jagged1-Fc. In human arteries engrafted into immuno-deficient mice, Notch pathway disruption had strong immunosuppressive effects, inhibiting T cell activation in early and established phases of vasculitis.
Notch and its ligand Jagged1 were abundantly expressed, and cleavage of Notch intracellular domain (NICD) in wall-infiltrating T cells indicated ongoing activation of the Notch pathway.
INS laboratorians have trained extensively with WHO and NICD scientists on influenza virus typing, subtyping, single and multiplex real-time RT-PCR, virus isolation, cell culture and specimen shipment.
The liberated cytoplasmic domain (NICD) translocates to the nucleus where it competes with corepressors (CoR) for binding to CSL, recruits coactivators (CoA) and forms a transcription-activating complex.
The next in line are the HIV and Malaria RDT products that are being readied for performance approval through the National Institute for Communicable Diseases (NICD).
In addition, NICD publishes a health care workers handbook on influenza which is circulated to stakeholders and published on NICD’s web page.
The generation of this proteolytic intermediate facilitates the subsequent intramembranous cleavage at the S3 site between glycine 1743 and valine 1744, that leads to the cytoplasmic release of the intracellular domain (NICD) (50).
The latter cleavage event liberates the Notch intracellular domain (NICD) to translocate to the nucleus where it binds to the transcription factor CSL(CBF-1/RBP-Jκ in mammals, suppressor of Hairless in Drosophila, and Lag-1 in C.
The INS Laboratory works closely with CDC, WHO, and the National Institute for Communicable Diseases (NICD) in South Africa to strengthen laboratory analysis activities.
The UTH Virology Laboratory (UTHVL) which has been functioning as Zambia’s National Influenza Center (NIC) worked closely with CDC, the National Institute for Communicable Diseases (NICD) in Johannesburg, South Africa and the WHO CC in London to strengthen influenza laboratories.