Lead Series definition

Lead Series means the structurally-related Derivative Compounds contained in a Lead Program. Each Lead Series shall contain at least [**] chemical entities.

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Lead Series means the collection of compounds within a single chemical series identified in the course of the Research either (a) which contains compounds which satisfy the criteria B.2 in Appendix B; or (b) which the JRC designates as a Lead Series.

Lead Series means on an Project-by-Project basis, a series of Project Compounds that includes Lead Candidate(s) wherein all such Lead Candidates and Project Compounds are Created within the same Project and are structurally similar Compounds which are derived from a common chemotype, as determined by the JPT and confirmed by the JSC.

Examples of Lead Series in a sentence

• From Lead Nomination onwards and throughout Lead Optimization, the structures of Other Compounds and Collaboration Compounds in the Lead Optimization phase shall be shared with the Roche project team members (including Collaboration Compounds meeting Lead Series Identified Criteria, CLS Criteria and CCS Criteria).

• It is anticipated that CFFT will seek a sublicensee to aid in the further development and commercialization of a Lead Series generated by SGX.

• SGX further acknowledges that CFFT may elect to invest additional funds in the continued development of the Structure Data or a Lead Series or Early Lead Series prior to seeking a sublicensee and that CFFT will seek a sublicensee either directly or indirectly after delivery by SGX of a Lead Series, Early Lead Series or Structure Data or at any point thereafter.

• The projected timeline for the FAST(TM) project directed against (DELTA)F508 NBD1 is illustrated in the accompanying Project Timeline, with the goal of identifying one or more Lead Series as defined in Appendix B.

• At CFFT's request, SGX shall promptly furnish the Structure Data, Early Lead Series and Lead Series to CFFT in such form as will allow CFFT to exercise its rights hereunder.

• The goal of the SGX-CFFT collaboration is to generate Lead Series that function as "[...***...]" of (DELTA)F508 CFTR and have the potential to be optimized and developed into therapeutics.

• All other activities pursuant to the Research Plan shall be managed by the JRC in accordance with Section 8.4 and Section 4.1.3. For clarity, the foregoing rights (i) shall not apply to any Library Compounds or Other Compounds that have not satisfied Lead Series Identified Criteria for Collaboration Targets […***…] or […***…] (as applicable), or any other Collaboration Targets, and (ii) shall terminate in full […***…] after the Effective Date.

• In the event that CFFT fails to exercise its good faith efforts to develop and commercialize a Collaboration Product within [...***...] years after the Completion Date, the rights to the Structure Data, Early Lead Series and Lead Series granted to CFFT pursuant to Section 4.1 shall revert to SGX and SGX thereafter shall have the right to develop, manufacture, make, have made, import, use, distribute, offer for sale and sell Collaboration Products.

• For the avoidance of doubt only one Option Exercise Fee payment shall be made for each respective Lead Series (including potential back up compounds) and only if Bayer exercised the Option for such respective Lead Series.

• During the term of this Agreement, Roche will keep SGX informed of its activities in connection with the development of Early Lead Series' and Collaboration Products, including without limitation, the achievement of events under Section 3.3. On a half-yearly basis up to Initiation of Phase 1 trials, and on a yearly basis thereafter during the term of the Agreement, Roche will provide SGX with a written summary report detailing such events and activities.

More Definitions of Lead Series

Lead Series has the meaning set forth in Section 2.4.

Lead Series means a set of compounds that meet the Lead Series criteria that is set forth in the applicable Joint Research Plan (“Lead Series Criteria”).

Lead Series means, for a Hit Program, a series of Compounds with a shared identical or closely-related molecular backbone that (a) are synthesized by or on behalf of Genentech or Kronos in the conduct of the Hit Program, and (b) [***] meet all Lead Series Criteria for such Hit Program, [***] or (ii) is otherwise designated by Genentech as a Lead Series in accordance with Section 3.3.1.1 (ESR Activities).

Lead Series means [***] which is approved [***]. Such approval will be based on [***];

Lead Series means, for a Stage 3 Small Molecule Program, a series of small molecules [***] (a) that are (i) synthesized by or on behalf of Recursion in the conduct of the Research Plan for such Stage 3 Small Molecule Program and (ii) either (A) for which at least [***] shown by or on behalf of Recursion in the conduct of such Research Plan to meet all Lead Series Criteria for such Stage 3 Small Molecule Program or (B) otherwise designated by Roche as a Lead Series in accordance with Section 4.2.2(a); or (b) that are otherwise designated by Roche as a Lead Series in accordance with Section 4.2.5.