IC50 definition

IC50 means the half maximal inhibitory concentration.

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IC50 means the inhibiting concentration for a 50% effect on the test organisms. It represents a point estimate of the concentration of test materials that can cause a 50% impairment in a quantitative biological function (e.g. reduced growth, impairment of the reproductive). These potential impacts do not kill the organism but may reduce the total population over time thereby decreasing aquatic productivity.

IC50 means the concentration of a compound that reduces activity of an enzyme by 50% in a standard, validated assay.

Examples of IC50 in a sentence

• Data were used for construction of concentration-response curves and determination of the IC50 value by use of Deltasoft 3 software.

• Biotinidase activity was assayed by the hydrolysis of 6-amidoquinoline (Apollo Scientific) as a fluorimetric substrate,23 and IC50 for biotinidase was determined as described for vanin activity.

• The [*] are collected onto [*] and IC50 values are determined as above.

• IC50 values (nM) given for a selection of FLT3 inhibitors (15, 28 – 30), which are more active than lead compound 27 based on their Ki values.

• Similar to zidebactam, nacubactam selectively inhibited PBP2 (IC50 = 0.12 μg mL−1) and upon incubation with E.

• Nitrocefin- based enzyme assays showed inhibition of TEM, CTX-M, KPC-2 (class A), AmpC and CMY-2 (class C) by nacubactam with sub-μM IC50 values.

• Compounds with Ki, IC50, or EC values below 10 μM were considered active.

• Each such notice shall set forth in writing the IC50 concentrations that such designated Lead Compound exhibits with respect to the relevant cell-based and enzyme assays established for such Collaboration Target under Section 2.5.9. Biogen Idec shall have complete discretion as to the designation of any Target Selective Compound within the Field as a Development Candidate by providing written notice to Sunesis of such designation.

• Additionally, assay results are to be rejected and re-performed if the measured IC50 values are lower than 50% of the enzyme concentration used.

• For each CART Activated Receptor subject to screening, Arena shall use Best Reasonable Commercial Efforts to identify at least [** *****************************] and to determine the IC50 Value and/or EC50 Value, whichever is applicable, with respect to such CART Identified Ingredient.

More Definitions of IC50

IC50 means the concentration of a compound that reduces activity of a COMT enzyme by 50% in a standard, validated assay.

IC50 means the point estimate of the concentration of a toxic substance, wastewater effluent or other aqueous mixture that would cause a 50% reduction in a nonlethal biological mea- surement, such as reproduction or growth, of the exposed test organisms in a given time period.

IC50. IC50 means the half maximal inhibitory concentration, which is the concentration of a compound needed to inhibit BTK activity by 50%.

IC50 means the point estimate of the concentration of a toxic substance, wastewater effluent or other aqueous mixture that would cause a 50% reduction in a nonlethal biological measurement, such as reproduction or growth, of the exposed test organisms in a given time period. SECTION 3. NR 106.03 (10) and (11) are repealed.