Hit Characterization definition
Hit Characterization means characterization of Hit Corrector Compound(s), Hit Potentiator Compound(s), or Hit Dual Potentiator-Corrector Compounds, as well as related chemical analogs that can be purchased or synthesized, to assess additional biological, ADME, and other drug-like characteristics for such compound(s), to generate initial structure-activity relationship(s) and for evaluation as a Lead Series or a Lead Compound. Such activities may include biological assays, ADME assays, PK assessment, intellectual property assessment, chemical synthesis and development of a scaffold-dependent computational model, and evaluation of other drug-like properties as determined by EPIX. One of the goals of the Hit Characterization is the identification of Lead Compounds along with an understanding of their properties that will need to be optimized during lead optimization.
Examples of Hit Characterization in a sentence
For each Discovery Research Program, within [***] following the JRC’s receipt of the results and data of the Hit Characterization Activities pursuant to Section 3.2.4 (Hit Characterization Activities), the JRC shall review such results and data and determine whether each Screening Hit meets the applicable criteria specified in the Discovery Research Plan (such criteria, the “Discovery Hit Criteria”).