Hit Characterization definition

Hit Characterization means characterization of Hit Corrector Compound(s), Hit Potentiator Compound(s), or Hit Dual Potentiator-Corrector Compounds, as well as related chemical analogs that can be purchased or synthesized, to assess additional biological, ADME, and other drug-like characteristics for such compound(s), to generate initial structure-activity relationship(s) and for evaluation as a Lead Series or a Lead Compound. Such activities may include biological assays, ADME assays, PK assessment, intellectual property assessment, chemical synthesis and development of a scaffold-dependent computational model, and evaluation of other drug-like properties as determined by EPIX. One of the goals of the Hit Characterization is the identification of Lead Compounds along with an understanding of their properties that will need to be optimized during lead optimization.
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Examples of Hit Characterization in a sentence

  • For each Discovery Research Program, within [***] following the JRC’s receipt of the results and data of the Hit Characterization Activities pursuant to Section 3.2.4 (Hit Characterization Activities), the JRC shall review such results and data and determine whether each Screening Hit meets the applicable criteria specified in the Discovery Research Plan (such criteria, the “Discovery Hit Criteria”).

Related to Hit Characterization

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  • Biomarker testing means the analysis of an Insured’s tissue, blood, or other biospecimen for the presence of a Biomarker. "Biomarker testing" includes but is not limited to single-analyte tests, multi-plex panel tests, protein expression, whole exome, whole genome, and whole transcriptome sequencing.

  • Distribution Protocol means the plan for distributing the Settlement Amount and accrued interest, in whole or in part, as approved by the Courts.

  • Template means a qualified software solution – based on Software - created by Partner in accordance with the solution qualification guidelines for Software. For details contact your Partner Service Advisor.

  • Treatability study means a study in which a hazardous waste is subjected to a treatment process to determine: (1) Whether the waste is amenable to the treatment process, (2) what pretreatment (if any) is required, (3) the optimal process conditions needed to achieve the desired treatment, (4) the efficiency of a treatment process for a specific waste or wastes, or (5) the characteristics and volumes of residuals from a particular treatment process. Also included in this definition for the purpose of the § 261.4 (e) and (f) exemptions are liner compatibility, corrosion, and other material compatibility studies and toxicological and health effects studies. A “treatability study” is not a means to commercially treat or dispose of hazardous waste.