FXR definition

FXR means means the foreign exchange rate ratio determined and calculated by the Calculation Agent in accordance with the following formula:FXfFXR = FXiWhere:“FXR” means the FX Rate ratio;“FXf“means the FX Rate determined by the Calculation Agent on the Final Index Valuation Date;“FXi“ means the FX Rate on the Initial Index Valuation Date, i.e. 3267.54 :USD1.00.“FX Rate” means the daily rate of exchange of ZAR per USD1.00, such rate as published on Bloomberg WMCO, or if any such rate is not available such other rate as selected or determined by the Calculation Agent, acting in good faith and in a commercially reasonable manner.“FXf“means the FX Rate on the Initial Index Valuation Date “P” means “participation” which is 1.50 (or 150%);“max” means “the maximum of” or “the greater of"; “min” means “the minimum of” or “the lesser of”;“IR” means the “Index Return” which the Calculation Agent will determine and calculate in accordance with the following formula:

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FXR means the exchange rate of U.S.$1 to Rouble in effect on the fourth Business Day (as defined in the Conditions) prior to the date on which the relevant payment in respect of the Notes becomes due, as set by the Central Bank of Russia and published on its website (https://www.cbr.ru/) or otherwise made available through the official exchange rate disclosure facilities used by the Central Bank of Russia from time to time.

FXR means ‘Foreign Exchange Rate’ detemined as USDZAR Final level / USDZAR Initial level.

Examples of FXR in a sentence

DSP shall not engage, directly or indirectly, in the commercialization of any other product FXR agonist compound or product in the Field within the Territory.
The FGF1 Licensing Agreement and the FXR Licensing Agreement amend and restate in its entirety that certain Exclusive Patent License Agreement, dated as of January 12, 2015, as amended, by and between Recipient and the Company.
The parties hereby agree that the issuance of the Stock pursuant to this Agreement satisfies all of the Company’s obligations to issue Common Stock of the Company pursuant to Section 4.1 of each of the FGF1 Licensing Agreement and the FXR Licensing Agreement, and after the issuance of the Stock, the Company shall not be obligated to issue any additional Common Stock of the Company pursuant to each of the FGF1 Licensing Agreement and FXR Licensing Agreement.
Metacrine represents and warrants that all of the patents and/or patent applications owned or controlled by Metacrine as of the Amendment Effective Date that cover FXR agonists for diagnosis, prevention and/or treatment of disease in humans are listed in Exhibit G.
FGF-19, a protein secreted from the gut directly under FXR control, with potent metabolic effects (20), showed a similar dose related increase (which may in part explain the weight loss).
FXR agonists have been shown to address three of the most important aspects of ▇▇▇▇ progression by reducing fat, inflammation and fibrosis in the liver.
Obeticholic acid (OCA) is a farnesoid X receptor (FXR) agonist and a modified bile acid that is derived from the primary bile acid chenodeoxycholic acid (CDCA), the natural human FXR ligand.
Two Novartis FXR agonists are now in worldwide clinical studies in ▇▇▇▇ patients.
At the same time, FXR activates BSEP to export BA in the bile, lowering the concentrations in the hepatocytes, and inhibits NTCP and uptake of BA into hepatocytes.
Approximately 5% of bile acids are lost through the faeces each day and replaced by synthesis (▇▇▇▇▇▇ and ▇▇▇▇▇▇▇, 2019) In the liver, bile acid homeostasis is controlled by FXR via SHP, which acts (1) on the uptake of BA by inhibiting the activity of NTCP and (2) on the synthesis of BA with the inhibition of CYP7A1 expression by repressing the hepatocyte nuclear factor 4 α (HNF4α) bound to its promoter (▇▇▇▇▇▇ et al., 2000; ▇▇▇▇▇▇ and ▇▇▇▇▇▇▇, 2019).

More Definitions of FXR

FXR means: (a) the protein encoded by the Farnesoid X Receptor gene (for any species); and (b) all subtypes, mutants, variants and fragments thereof.

FXR means the FX Rate on Reset Date (r) immediately preceding such Business Day (t), quoted in units of the Specified Currency per 1 US Dollar or, if such Business Day is prior to the first Reset Date to occur after the Issue Date, the Initial FX Rate, quoted in units of the Specified Currency per 1 US dollar;

FXR. )" means the FX Rate on the Valuation Date immediately preceding such Reset Date, quoted in units of the Specified Currency per 1 US dollar.

FXR means the FX Reserve at that date.

FXR means an amount equal to the quotient of (i) the FX (Final), divided by (ii) the FX (Initial), as determined by the Calculation Agent.

FXR means the foreign exchange rate ratio calculated by the Calculation Agent in accordance with the following formula: