FSHR definition
Examples of FSHR in a sentence
We demonstrated that the administration of 2 doses of 1.5 million FSHCER T cells targeting murine FSHR into peritoneal ovarian cancer (ID8-Vegf/Defb29)-bearing immunocompetent mice delayed malignant progression without any alterations in hepatic enzymes, creatinine or any other obvious sign of toxicity3.
The goal of this project is to develop a new Chimeric Endocrine Receptor T cell (CERTcell™) therapy against ovarian and prostate cancer, which is similar to chimeric antigen receptors (CARs) T cell therapy but instead using the natural receptor-ligand interactions between follicle-stimulating hormone (FSH) and its receptor (FSHR) expressed on ovarian tumor cells.
Consistently, the growth of established FSHR+ human ovarian cancer CaOV3 tumors was significantly delayed in mice receiving a single injection of 6 million CERT cells, while administration of mock-transduced T cells allows tumor progression.
Given that oophorectomy is a standard procedure in the treatment of ovarian cancer, targeting the FSHR will not damage healthy tissues.
Our current expectations for clinical protocol planning and drafting, to be modified depending on the FDA’s feedback, are outlined below: -The initial trial should be designed as an open-label, single-arm pilot clinical trial of autologous FSHR redirected T cells administered intraperitoneally in patients with recurrent, chemoresistant FSHR+ ovarian carcinoma that expresses FSHR, as determined in previous biopsies or the original tumor by western-blot analysis.