DMPK definition

DMPK means Drug Metabolism and Pharmacokinetics, studies designed to determine the absorption and distribution of an administered drug, the rate at which a drug takes effect, the duration a drug maintains its effects and what happens to the drug after being metabolized by the body
View Source
DMPK means myotonic dystrophy protein kinase.
View Source
DMPK means drug metabolism and pharmacokinetics.
View Source

Examples of DMPK in a sentence

  • CDHP / DSE / DMPK (LO) Determine starting doses for FIM, safety, Clinical PK issues once appropriate DSE studies are completed and if available Review DSE/eADME data for targeted organ toxicity, safety margins, QTc issues, BA, etc.

  • DM1 is an RNA dominant disorder caused by expansion of a CTG repeat in the 3’-UTR of the DMPK gene.

  • Quest will be responsible for handling and shipping DMPK Specimens.

  • Examples of team representatives may include discovery, precision medicine, pre-clinical safety, legal, intellectual property, statistics, clinical operations, DMPK, process sciences, manufacturing, market research, product development, commercial, marketing or any other function deemed applicable to the stage of Development or Commercialization for the applicable Licensed Product(s).

  • DMPK specimens shipped to Quest designated for extended storage shall be stored and maintained by Quest for the length of time and under storage conditions as described in the relevant CLW.

  • Blood, Plasma and GI fluid stability > 80% remaining at 4 hours DMPK Absolute oral bioavailability (ABA), (oral products only – using aqueous solutions or Hydroxy Ethyl Cellulose (HEC) suspensions or clinically accepted formulation).

  • Note: Compounds failing ABA test can be progressed if > 20% ABA can be achieved using clinically acceptable formulations >20% in 2 animal species DMPK (with input from GPD as appropriate) * The asterisk denotes the confidential portions of this exhibit have been omitted in reliance on Rule 24b-2 of the Securities Exchange Act of 1934.

  • If requested by GSK, Quest will be required to send any DMPK specimens received by Quest in extended storage to other laboratories for analysis ("DMPK Specimens").

  • Isis and Biogen Idec are subject to exclusivity obligations under Section 2.1; however, the Parties acknowledge and agree that each Party (on its own or with a Third Party) may continue to discover, research, develop, manufacture and commercialize products that are designed to bind to the RNA that encodes a gene that is not DMPK for any indication, even if such products are designed to treat Myotonic Dystrophy-Type 1.

  • The Compounds are designed to bind to the RNA that encodes DMPK in the Field, which is known to play a role in Myotonic Dystrophy-Type 1.


More Definitions of DMPK

DMPK means distribution, metabolism and pharmokinetics of a pharmaceutical compound (measurement of the pharmaceutical compound or its metabolites in body fluid).
View Source
DMPK means the gene, dystrophia myotonica protein kinase (GenBank accession # NM_001081560.1; Gene ID: 1760), or any alternative splice variants, mutants, polymorphisms and fragments thereof.
View Source

Related to DMPK

  • Bioassay means the determination of kinds, quantities or concentrations, and, in some cases, the locations of radioactive material in the human body, whether by direct measurement, in vivo counting, or by analysis and evaluation of materials excreted or removed from the human body. For purposes of these regulations, "radiobioassay" is an equivalent term.

  • Embryo/fetus means the developing human organism from conception until the time of birth.

  • DS Electric generation service that is provided at retail pursuant to the Applicable Legal Authorities under the Company’s retail electric tariffs and under any other agreements or arrangements between the Company and Customers, to any Customer that is not being served by an EGS. Default Allocation Assessment – shall have the meaning ascribed to it under the PJM Agreements. Delivery Period – The delivery period specified in an Appendix C Transaction Confirmation. Delivery Point – Means the applicable zone of the Company as designated by PJM. DS Customer(s) – Retail customers who are provided Default Service pursuant to the terms of this Agreement, the Applicable Legal Authorities and the Company’s retail tariffs.

  • thalassemia means a group of inherited disorders characterised by reduced or absent amounts of haemoglobin.

  • HBV means hepatitis B virus.