Derivative Compounds definition
Derivative Compounds means any and all compounds that are modified by chemical and/or molecular-genetic means from a Library Compound. Analogues of such compounds and their derivatives shall be included within the scope of Derivative Compounds.
Derivative Compounds means any analogs, homologs or isomers of a Designated Screening Compound, a Designated Shared Compound and/or an Independent Compound, as applicable. DESIGNATED COMPOUNDS means Designated Screening Compounds and Designated Shared Compounds. DEVELOPMENT shall mean the development of any Shared Product occurring from and after the filing of an IND, through and including approval of an NDA and any other Regulatory Approvals required for the Manufacture and Commercialization of such Shared Product in a country. Development shall not include Pre-Clinical Development activities. DEVELOPMENT COSTS shall mean all costs and expenses reasonably resulting directly from the Pre-Clinical Development of any Designated Shared Compound or Development of any Shared Product, as well as Overhead costs of the functions that directly support such Pre-Clinical Development or Development (as calculated in accordance with GAAP and using the same allocation methods that the party incurring such costs uses throughout its operations, but in all events excluding General Corporate Overhead), all as specified in the Development Plan and the Development Budget. DEVELOPMENT COSTS shall include, without limitation: (i) the Cost of Goods for the Designated Shared Compound used in such Pre-Clinical Development or Shared Product used in such Development (including early batches of the Shared Product for use in obtaining Regulatory Approval, to the extent not re-used later in commercial sales); (ii) direct costs for third party professional Pre-Clinical Development or Development services, including without limitation toxicology studies or clinical studies performed by third parties; (iii) direct charges for materials (including without limitation chemicals, animals and lab supplies); (iv) labor and materials *=CONFIDENTIAL TREATMENT REQUESTED: MATERIAL HAS BEEN OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 1 costs and fees incurred in connection with securing Regulatory Approvals; (v) labor and materials costs for the Development of the Manufacturing process for Shared Products and scale-up of such process; and (vi) the costs of FTEs dedicated to the foregoing activities. DIRECT ADMINISTRATIVE EXPENSES means the costs of invoicing, tracking and administering rebate and chargeback programs and product returns and of establishing and maintaining contracts with managed care organizations and governmental purchasers. DISTRIBUTION COSTS means the costs of distributing and shipping the Shared...
Derivative Compounds. Derivative Compounds means, with respect to any Licensed Compound, any compounds actually chemically derived, in one or more steps, by or on behalf of PRESIDIO, its Affiliates and/or Third Party sublicensees from such Licensed Compound, provided that, compounds derived by Third Party sublicensees or Third Party acquirers of PRESIDIO shall not constitute Derivative Compounds if such compounds are so derived (i) prior to the effective date of the grant by PRESIDIO of the sublicense to such sublicensee or the acquisition by such acquirer, as evidenced by contemporaneously prepared written records of such sublicensee or acquirer or (ii) without any use, direct or indirect, of (A) proprietary know-how disclosed to such Third Party in connection with the grant of the sublicense or the acquisition, or (B) Licensed Compounds (including Derivative Compounds) on which Development had previously been conducted by XTL or PRESIDIO, the results of which prior Development are identified to such Third Party in connection with the grant of the sublicense or the acquisition.
Examples of Derivative Compounds in a sentence
This will include allocation of the medicinal chemistry FTEs, as well as additional FTEs to provide bioassay support, as necessary, for each Optimization Program to generate primary assay data for Lead Compounds and Derivative Compounds.
In performing each Optimization Program, Pharmacopeia shall undertake the synthesis of analogs and other Derivative Compounds based upon the relevant Lead Compounds.
It is understood that such licenses shall include the right to conduct drug research and development, and the exclusive right to discover, develop, make, have made and use such Lead Compounds and corresponding Derivative Compounds, during the term of this Agreement.
Any Pharmacopeia employees assigned to work exclusively on Collaboration research projects shall also be subject to non-compete obligations, as set forth below, with respect to any Target with respect to which Collaboration research efforts directed to such Target are performed at Pharmacopeia (including, without limitation, the design and synthesis of Derivative Compounds based on Lead Compounds).
Pharmacopeia will also conduct primary screening assays of all such Derivative Compounds to determine activity against the applicable Target.
More Definitions of Derivative Compounds
Derivative Compounds means any derivatives or analogs for a Designated Compound, which have an IC50 value against the Target of [*] or less, which (a) results from a chemical synthesis program based on the Designated Compounds or (b) is based on structure-activity data of the Designated Compound; PROVIDED, that any such program or data is in respect of a target protein that is greater than [*] homologous at the peptide level to the Target for which Mitsubishi designated such Designated Compound.
Derivative Compounds means any one or more Compound(s) made by or on behalf of Array, other than in the course of the Research Program, from the commencement date of the Research Program Initial Term until termination of the Agreement which (i) result from a chemical synthesis program based on a Collaboration Compound; (ii) are based on structure-activity data relating to Collaboration Compounds which are active or inactive in the Research Field; or (iii) are claimed in any patent application or patent filed by Amgen under Section 6.2 or by Array, which patent application or patent discloses any compound in subsection (i) or (ii) above.
Derivative Compounds has the meaning given in Section 2.5(b).
Derivative Compounds means, individually any JJPRD Derivative Compound or Sunesis Derivative Compound, and collectively JJPRD Derivative Compounds and/or Sunesis Derivative Compounds, as the case may be.
Derivative Compounds means, with respect to a particular Licensed Compound referenced in Section 1.108(a), (b) or (c):
(a) any prodrugs, metabolites (including all nucleotide metabolites and mimetics thereof) and prodrugs of any such metabolites, in each case, of such Licensed Compound;
(b) all stereoisomers, including enantiomers and diastereoisomers thereof, of such Licensed Compound;
(c) all tautomers, including purified tautomers, the corresponding tautomeric mixtures and any combination of tautomers in any degree of tautomeric purity of such Licensed Compound;
(d) all salt forms and esters of such Licensed Compound; and
(e) all crystal, amorphous forms, and polymorphic forms of such Licensed Compound.
Derivative Compounds means any analogs, homologs or isomers of a Designated Screening Compound, a Designated Shared Compound and/or an Independent Compound, as applicable.
Derivative Compounds means any analog, homolog or isomer of a Lead Compound, which has an IC50 value against the Screening Target of [*] micromolar or less, which (a) results from a chemical synthesis program based on the Lead Compounds or (b) is based on structure-activity data of the Lead Compound; PROVIDED, that any such program or data is in respect of a target protein from other bacterial or fungal organisms homologous in origin and biological function to the original Screening Target.