Degrader definition

Degrader means [***].
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Degrader means with respect to a Collaboration Target, a compound comprising (a) a Target Binding Moiety, (b) optionally, a Linker, and (c) an E3 Ligase Binding Moiety that degrades such Collaboration Target.
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Degrader means a compound that consists of a Proteasome Protein Binder, a Degrader Spacer, and a Degrader Target Binder.
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Examples of Degrader in a sentence

  • Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression.

  • A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo.

  • Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7.

  • Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development.

  • In case A public information was the key factor that made it possible to identify the opportunity.

  • A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader.

  • SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression.

  • For clarity, ownership of Foreground IP that primarily relates to (i) attachment moieties, generally, or (ii) without limiting the definition of “Foreground DEL IP” hereunder, any process or method of attaching attachment moieties to chemical entities, generally, shall follow inventorship, as determined in accordance with this Section 15.1.2 (Foreground IP), and such Foreground IP shall not be considered Foreground DEL IP, Foreground Degrader IP or Foreground Antibody/Conjugation IP hereunder.

  • CALO: pure CsI 240-element calorimeter BC: upstream Beam CounterAC1,2: Active beam Collimators AD: Active Degrader detector AT: Active Target detectorMWPC1,2: Multi-Wire Proportional Chambers PH: Plastic Hodoscope, 20 staves(MWPCs, PH have cylindical shape) AC1π+ VACUUM pureCsIPiBeta detector(PiBeta Runs 1-4) PH MWPC1beamBCAD ATAC2 MWPC2 ////CALO~3 m flightpath//// /: 10 cm Figure 24.1: Schematic cross section of the PiBeta apparatus, with its main compo- nents labeled.

  • Thereafter, Vertex shall prepare and provide to Company a work plan for its conduct of a target validation experiment in [***] using such [***]Degrader and shall consider any comments from Company on such work plan in good faith (such experiment, the “Validation Experiment” and such work plan, the “Validation Experiment Work Plan”).


More Definitions of Degrader

Degrader means a heterobifunctional molecule designed to affect the degradation of a Target of interest and that is comprised of [***].
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Related to Degrader

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