Clinically actionable definition

Clinically actionable means that there are established therapeutic or preventive interventions or other available actions that have the potential to change the clinical course of the disease/condition, or lead to an improved health outcome.
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Examples of Clinically actionable in a sentence

  • Clinically actionable findings for the purpose of this study are defined as disorders appearing in the American College of Medical Genetics and Genomics recommendations for the return of incidental findings that is current at the time of primary analysis.

  • Clinically actionable findings for this study are defined as disorders appearing in the American College of Medical Genetics and Genomics recommendations for the return of incidental findings that is current at the time of primary analysis.

  • Clinically actionable genotypes among 10,000 patients with preemptive pharmacogenomic testing.

  • The legal next of kin would be offered genetic counseling that would include the distinction between a clinical and research finding and would be offered the opportunity to have those findings confirmed in a living relative of the patient.Note: Clinically actionable findings for the purpose of this study are defined as disorders appearing in the American College of Medical Genetics and Genomics recommendations for the return of incidental findings that is current at the time of primary analysis.

  • Clinically actionable findings should be communicated to research participants through caregivers, unless participants have objected to being recontacted during informed consent procedures.

  • Clinically actionable mutation profiles in patients with cancer identified by whole-genome sequencing.

  • Case study 3: Clinically actionable variants an individual genome To identify variants with potential for clinical relevance, we applied filters to the whole genome sequence variation of a phenotypically normal individual obtained from the Personal Genome Project (Profile hu3BDC4B, https://www.personalgenomes.org)18.

  • Clinically actionable alterations to be included in the primary analysis: Exon 19 deletions, L858R, L861Q, G719X and S768I APPENDIX II Table 6.

  • Clinically actionable “Omics”: the personalome for Precision Therapy.

  • Clinically actionable alterations are characterized as those associated with FDA-approved therapeutics for on- or off- label use, as well as pathogenic or likely pathogenic germline variations.

Related to Clinically actionable

  • Biological Samples means any physical samples obtained from Study Participants in accordance with the Protocol for the purposes of the Study.

  • in vitro diagnostic medical device means any medical device which is a reagent, reagent product, calibrator, control material, kit, instrument, apparatus, equipment, software or system, whether used alone or in combination, intended by the manufacturer to be used in vitro for the examination of specimens, including blood and tissue donations, derived from the human body, solely or principally for the purpose of providing information:

  • medically approved means certified by a medical practitioner;

  • Clinical Study means a Phase I Study, Phase II Study, Phase III Study, as applicable.

  • Study means the investigation to be conducted in accordance with the Protocol.

  • Technically Feasible refers solely to technical or operational concerns, rather than economic, space, or site considerations.

  • Infectious Disease means an illness that is capable of being spread from one individual to another.

  • Biological agent shall mean any pathogenic (disease producing) micro-organism(s) and/or biologically produced toxin(s) (including genetically modified organisms and chemically synthesized toxins) which cause illness and/or death in humans, animals or plants.

  • Massive Multiauthor Collaboration Site (or “MMC Site”) means any World Wide Web server that publishes copyrightable works and also provides prominent facilities for anybody to edit those works. A public wiki that anybody can edit is an example of such a server. A “Massive Multiauthor Collaboration” (or “MMC”) contained in the site means any set of copyrightable works thus published on the MMC site.

  • Speech pathologist means a person who engages in the application of principles, methods, and procedures for the measurement, testing, evaluation, prediction, consultation, counseling, instruction, habilitation, rehabilitation, or remediation related to the development and disorders of speech, fluency, voice, or language for the purpose of nonmedically evaluating, preventing, ameliorating, modifying, or remediating such disorders and conditions in individuals or groups of individuals.

  • Financially Literate means the ability to read and understand a set of financial statements that present a breadth and level of complexity of accounting issues that are generally comparable to the breadth and complexity of the issues that can reasonably be expected to be raised by the Corporation’s financial statements.

  • Environmentally sensitive area means any area in which plant or animal life or their habitats are either rare or especially valuable because of their special nature or role in an ecosystem and which could be easily disturbed or degraded by human activities and developments.

  • Third Party Action means any suit or proceeding by a person or entity other than a Party for which indemnification may be sought by a Party under Article VII.