CD38 definition

CD38 means the glycoprotein Cluster of Differentiation 38 also known as ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase 1.
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Examples of CD38 in a sentence

  • The Development Plan shall be consistent with I-Mab’s obligation under the MorphoSys License with respect to the Development of the CD38 Product.

  • Although immune recruitment can be a potent mechanism of cell-kill, roughly 70% of CD38+ refractory patients fail to respond to daratumumab monotherapy.

  • Daratumumab works primarily by directing complement dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC) to CD38+ myeloma cells.

  • In 2015, daratumumab, an antibody to CD38, and elotuzumab, an antibody to CS1, became the first biologics approved for multiple myeloma.

  • Recently, daratumumab, an antibody that specifically targets CD38, was approved for the treatment of patients with multiple myeloma.

  • MT-4019ND is a fusion of an antibody fragment that binds CD38 with a highly toxic bacterial protein.

  • Molecular Templates, a venture-backed biopharmaceutical company in Georgetown, TX, has developed a novel multiple myeloma drug that targets CD38 but works in a different way from daratumumab.

  • Daratumumab in particular has shown robust single-agent activity (29% response rate) in relapsed/refractory patients indicating that CD38 plays an important role in myeloma disease progression.

  • CD38 was chosen as a target because of the clinical activity of daratumumab.

  • MT-4019ND was engineered to provide a different mechanism of destruction targeting CD38+ myelomas.