CAIA definition
Examples of CAIA in a sentence
To become a CAIA charterholder, a candidate must meet these four requirements: 1) pass a two-tier exam process (passing both the Level I and Level II exams); 2) hold a U.S. bachelor's degree or the equivalent, and have more than one year of professional experience, or alternatively have at least four years of professional experience.
The CAIA charter is the global ▇▇▇▇ of distinction in alternative investments.
Ideally, analgesics are administered to mice undergoing CAIA, provided these compounds should not interact with the induction of the arthritis or the functionality of the therapeutics under investigation.
Nonetheless, since there were no experimental groups receiving only paracetamol or tramadol, possible anti-inflammatory effects of tramadol alone cannot be dismissed and this should be investigated before using tramadol only in the CAIA model.
The CAIA model is suitable to study the effects of anti-inflammatory drugs on arthritis, nevertheless the severity of discomfort induced by this model makes it desirable to reduce pain and improve the welfare of the mice.
Since these parameters are influenced by TP, TP analgesia resembles a confounding factor and should therefore not be used when investigating novel GCs and their (in)ability to induce side effects in the CAIA model.
In the present study, we have determined whether the combination of paracetamol and tramadol (TP) interferes with the CAIA model when testing the anti-inflammatory effects of the GC Pred.
Nevertheless, the application of an analgesic that does not interfere with the CAIA model or Pred activity would be a recommended candidate for rescue analgesia, although such application should be extensively investigated beforehand.
Wicklund, CFA*, CAIA**, Managing Director Form ADV Part 2B Brochure Supplement Wilshire Advisors LLC 1299 Ocean Ave, Suite 700 Santa Monica, CA 90401 310 451 3051 This Brochure Supplement provides information about Anthony R.
Our observations indicate that TP analgesia can influence disease severity and interferes with several Pred-induced (side) effects, making TP incompatible with testing Pred and possibly also other GCs in the CAIA model.