BMP-7 definition
Examples of BMP-7 in a sentence
BMP7 counteracts the increased expression of several extracellular matrix (EMC) proteins and CTGF (connective tissue growth factor) 84, 102 .
Except for the Excluded Assets, the Purchased Assets include all of the tangible personal properties, Intellectual Property and other assets owned by Seller or Stryker that are solely and exclusively related to the BMP-7 Products.
CURIS has on-going research and certain product development and clinical development capabilities and has identified a lead compound, BMP-7 with the potential to be further developed for the treatment of renal disease and related disorders or disorders of the nervous system, from acute or chronic insults.
Furthermore, knockout studies have shown that BMP7 (and BMP4) are essential for early morphogenesis of the eye 81-83, 100, 101 .
BMP7 also plays a role in various pathological conditions (inflammation, diabetic retinopathy, fibrosis).
BMP7 knockout mice revealed deficient ocular growth, resulting in epithelial development disturbances, e.g. absence of the lens and abnormal retinal organization, with disorganization of the pigment layer of the retina 82 .
For example: BMP7 null mice display lack of eye and glomerular development, leading to renal failure and neonatal death 81-83 .
The TGFβ superfamily consists of three subtypes: TGFβ1, TGFβ2, and TGFβ3 and TGFβ1 family include the BMPs. BMP-2, BMP-4 and BMP-7 are members of BMP signalling molecules which critically modulate osteoblast commitment and differentiation.
Increased Bmp7 expression in all endochondral skeletal elements of compound Col2a1-Cre;Apc15lox/1638N and Col2a1-Cre;Apc15lox/1572T conditional mutants We previously reported in vitro, that murine mesenchymal-like cells carrying a knockdown of the Apc gene not only express higher levels of Bmp7 mRNA, but are also more responsive to recombinant human BMP-7 during osteoblastogenesis (25).
One member of the BMP family, the 35-kDa homodimeric protein BMP7, appears to be a prerequisite for induction of condensation and epitheliazation of metanephric mesenchyme in the kidney 65, 98, 99 .