BACE definition

BACE means the BACE (Beta-Amyloid precursor protein-Cleaving Enzyme), also known as B▇▇▇▇, ▇▇▇▇, and memapsin2, is a 501 amino acid aspartyl protease defined by the sequence reported by Vassar, et al ((1999) Science 286,735-741). MEROPS ID# A01.004 (Rawlings, N.D., O’Brien, E.A. & B▇▇▇▇▇▇, ▇.▇. (2002) MEROPS: the protease database. Nucleic Acids Res. 30,343-346.), NC-IUBMB # not yet assigned.
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Examples of BACE in a sentence

  • BI has decided to advance either BACE Inhibitor ****or BACE Inhibitor **** to Development Candidate Selection and agrees to pay the milestone payment according to Section 9.3.1 of the Agreement.

  • In the event that membership falls below 75%, representatives of the Board and BACE will meet to review the circumstances upon which membership was reduced.

  • An agency fee will be implemented when BACE attains 80% membership.

  • There can be no guarantee that AMG 334, CNP520, AMG 301, other BACE inhibitors of Novartis and Amgen, or other investigational compounds of Novartis and Amgen subject to the collaboration will be submitted or approved for sale in any market, or at any particular time.

  • The companies are partnering in the development and commercialization of a beta-secretase 1 (BACE) inhibitor program in AD.

  • Novartis' oral therapy CNP520 (currently in a Phase II/III study for AD) will be the lead molecule and further compounds from both companies' pre-clinical BACE inhibitor programs may be considered as novel follow-on molecules.

  • The Company will not, and will not permit any Subsidiary to, amend or modify any provision of the BACE Management Agreement relating to the compensation payable to BACE and any of its Affiliates.

  • Slancik shall not sell, transfer or otherwise dispose of, hypothecate or otherwise encumber (voluntarily or involuntarily) (any such sale, transfer, disposition, hypothecation or encumbrance being referred to as a "transfer") any common stock of Optimal ("Common Stock") without the written approval of BACE.

  • No assignment hereof shall be effective until Slancik making an assignment hereof delivers to BACE an executed counterpart of this Agreement by the transferee or an agreement in writing executed by the transferee to be bound by the terms hereof to the same extent as if such transferee was Slancik hereto.

  • The Plaintiffs are seeking repayment of promissory notes in the aggregate amount of $6,905,946, with interest, made by BACE in connection with BACE’s prior acquisition of American Staff Resources Corporation, and its affiliates (“ASR”), which are currently operating subsidiaries of the Company.

Related to BACE

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