Autoplex definition

Autoplex single amplification reaction • How can this information be useful? Aren’t the Current STR Loci Good Enough? • For general forensic matching of evidence to suspect, the 13 CODIS STR loci are sufficient • For other human identity/relationship testing questions, more autosomal loci can be beneficial or even necessary • Missing Persons and Disaster Victim Identification (kinship analysis) • Immigration Testing (often limited references) – Recommendations for 25 STR loci • Deficient Parentage Testing – often needed if only one parent and child are tested Relationship testing labs are being pushed to answer more difficult genetic questions…and we want to make sure the right tools are in place Selection of New Autosomal Loci • Aim to have candidate sets for optimal miniSTRs • Using ~900 STR loci with some literature data as a starting point… – Loci with high heterozygosities (>0.7) – Loci with small allele ranges (<24 bp) – low mutation? – Tetra (some tri-)nucleotide repeats without variants – Clean flanking regions (PCR products <140 bp) • 26 loci met criteria and fully characterized… ▇▇▇▇▇ and ▇▇▇▇▇▇ (2005) Characterization of new miniSTR loci to aid analysis of degraded DNA J. Forensic Sci. 50(1): 43-53 Initial Testing Results with Potential miniSTR Loci 20 additional loci characterized across U.S. population groups ▇▇▇▇▇ and ▇▇▇▇▇▇ (2005) J. Forensic Sci. 50(1): 43-53 Characterizing New Loci ✓ Select genetic loci ✓ Design primers – optimize multiplex assay ✓ Type population samples to examine variation ✓ Sequence alleles to establish nomenclature ✓ Develop bins and panels for genotyping ✓ Construct allelic ladders ✓ Evaluate RMP or ability to separate common types ✓ Perform mutation rate studies ✓ Perform concordance studies (when applicable) ✓ Calibrate genotypes with NIST SRM components ✓ Work with companies/collaborators ✓ Publish details on loci and assays Test Markers on Sequence Build Macros for Construct 11 0.1385 0.1525 0.1500 African American 0.788 Population samples homozygotes todetermine allele sizes Genotyping Allelic Ladders 12 0.2154 0.1004 0.1786 U.S. Hispanic 0.879 15 0.0577 0.0772 0.0714 9 11 12 14 15 17 16 0.2981 0.1004 0.2643 19 17 0.0981 0.0521 0.0679 18 0.0096 0.0058 0.0071 European Labs Have Adopted the NIST-Developed NC (non-CODIS) miniSTRs FSI (2006) 156(2): 242-244 • Characterization of 26 new autosomal loci • Primer sequences, GeneMapper bins and panels, genotypes on common samples, and allele frequency information already availabl...

Split View

AI-Powered Contracts

Draft, Review & Redline at the Speed of AI

Get StartedBook a Demo

Autoplex or “miniMegaplex” 26plex All loci unlinked from core (CODIS) STRs 9947A ? ? ? Mother/Child with mutation ? ?

Autoplex means the Factor VIII Inhibitor Treatments marketed by Baxter.

Examples of Autoplex in a sentence

• The focus of this document is OA&M features offered in the Autoplex 1000 System, including the Access Manager, 5ESS-2000 DCS, Operation Maintenance Platform - Simplex, Operational Maintenance Platform-FX, and AutoPACE.

• The purpose of the divestiture is to ensure the continued competition between Autoplex and FEIBA in the United States, in the same manner in which these products would compete absent the Acquisition, and to remedy the lessening of competition resulting from the proposed Acquisition as alleged in the Commission s complaint.

• Fort Worth, TX SON MCKNY II, L.P. Sonic — ▇▇▇▇▇ ▇▇▇▇▇ Autoplex, L.P. Texas Limited Partnership 800079059 ▇▇▇▇▇ ▇▇▇▇▇ Chevrolet ▇▇▇▇▇ ▇▇▇▇▇ Chrysler Jeep ▇▇▇▇▇ ▇▇▇▇▇ Chrysler Jeep Dodge 10▇▇ ▇.

• The parties further agree that permitted signage for the Autoplex shall include signs of the size and type described in the Sign Package Criteria attached hereto as Exhibit B.

• The configuration of the Autoplex is such that appropriate signage should enhance its visibility and high profile nature, and is essential to the continued success of the Autoplex.

• The closing for the consummation of the transactions contemplated by this Agreement (the “Closing”), shall take place, unless another date or place is agreed to in writing between the parties, on March 10, 2004, at the offices of Advantage Autoplex, Inc., Houston Texas or such other date and location as the parties may mutually determine (the “Closing Date”), subject to the right of either party to terminate this Agreement pursuant to Section 12.1 below.

• In the event that the Acquirer does not choose to acquire all of the physical assets included in the Autoplex Assets because the Acquirer does not need such physical assets in order to engage in the manufacture and sale of Factor VIII Inhibitor Treatments, Respondent shall not be required to divest such assets.

• For each new swapout market where the Customer pays for cell site engineering, Seller will provide, at no additional charge, the following: (a) One (1) set of CD/ROM and one set of paper documentation at the MSC site, (b) One (1) Autoplex CD/ROM per technician based on one technician for each 15 cells, and (c) One (1) set of drawings per cell site, as identified by the 183 or equivalent engineered specifications.

• The Autoplex Assets shall be divested only to, and the agreement executed only with, an Acquirer that receives the prior approval of the Commission and only in a manner that receives the prior approval of the Commission.

• Cellular Digital Packet Data Engineering Drawings Transmission Documents Customer Information Bulletins Engineering Letters Schematic Drawings Wall Charts Optional Binders Autoplex System Document Kits .