AP1 definition
Examples of AP1 in a sentence
Our simulations and experimental results point to a potential role of TLR5 co-stimulatory signals in the activation and differentiation of CD4+ T cells through the induction of AP-1, CREB, and NF-кB activation, which can in turn induce (directly or through other transcription factors) the expression of several genes encoding cytokines, receptors, and signaling molecules.
According to our modeling and experimental results, the TLR5 pathway cooperates with TCR signals to induce NF-кB and AP-1 activation.
Together, downstream of TLR signaling, NF-кB, AP-1, and CREB are activated.
Thus, TLR5 contributes to overcome the higher activation threshold of neonatal CD4+ T cells, which are characterized by defective TCR/CD28–mediated AP-1 activation (79).
The main transcription factors that mediate TCR-inducible gene expression are: NFAT (Nuclear Factor of Activated T cells), NF-кB (Nuclear Factor kappaB), AP-1 (Activator protein 1), and CREB (cAMP Response Element Binding) (20, 23–28).
The activation of TLRs can also stimulate the phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) pathway, leading to the activation of the transcription factors AP-1 and CREB (49–51).
In summary, combining computational modeling and experimental validations, our combined experimental and modeling analysis demonstrates that TLR5 is a co-stimulatory receptor for CD4+ T cells, and that it uses a different pathway than that used by CD28 to induce the activation of the transcription factors NF-кB and AP-1.
This excludes the application for wedding (AP1) and public entertainment licenses which need to be obtained by the Client.
The putative GA733-2 promoter contains consensus binding sites for the Sp1 and AP-1 transcription factors, but no TATA or CAAT boxes were found (▇▇▇▇▇▇▇▇▇▇ et al., 1993).
Control of endothelial cell tube formation by Notch ligand intracellular domain interactions with activator protein 1 (AP-1).