Anergy definition

Anergy means the absence of a reaction to skin test antigens, such as tuberculin (when the person is infected with the organism tested) because of immunosuppression. The absence of a reaction to the tuberculin skin test does not rule out the diagnosis of tuberculosis (TB) infection or disease. Anergy may be caused by many factors, such as HIV infection, overwhelming miliary or pulmonary TB, severe or febrile illness, measles or other viral infections, Hodgkin's disease, sarcoidosis, live virus vaccination, and the administration of corticosteroids or immunosuppressive drugs.
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Examples of Anergy in a sentence

  • Sponsor will provide Interferon-Alpha, BriaVax, DTH (BriaTest), Anergy tests (Candin), and cyclophosphamide Study drugs.

  • Anergy, advanced age, severe disease, HIV/AIDs profile, and immunosuppressive therapy have been shown to cause false-negative IGRA results, and influence TST+/IGRA- discordance (174, 180).

  • Deletion Anergy iNOS and/or ARG I inhibitors (NCX-4016, (LYC-55716) ARG I iNOS CD73 CD39 RORγt TCR Adenosine A2A receptor ATP PD-1 PD-L1/2 (celecoxib, indoximod, MHCI ↓ epacadostat) A2A receptor antagonists (AZD4635, CPI-444) ARG I ↑ EP2/EP4 ↑ ▇▇▇-2 ↑ IDO1 ↑ EP2/EP4 antagonists (PF-04418948, AH6809) CD80/CD86 MHCII LAG3 One such a TME target is IDO1.